Boron-Based Compounds. Potential and Emerging Applications in Medicine

  • ID: 4403402
  • Book
  • 496 Pages
  • John Wiley and Sons Ltd
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Noted experts review the current status of boron–containing drugs and materials for molecular medical diagnostics

Boron–Based Compounds offers a summary of the present status and promotes the further development of new boron–containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules. This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds.

The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron– and carborane–containing compounds in drug design. Authoritative and accessible, Boron–Based Compounds:

  • Contains contributions from a panel of internationally renowned experts in the field
  • Offers a concise summary of the current status of boron–containing drugs and materials used for molecular diagnosticse
  • Highlights the range and capacity of boron–based compounds in medical applications
  • Includes information on boron neutron capture therapy and diagnostics

Designed for academic and industrial scientists, this important resource offers the cutting–edge information needed to understand the current state of boron–containing drugs and materials for molecular medical diagnostics.

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List of Contributors vii

Preface xi

Part 1 Design of New Boron based Drugs 1

1.1 Carboranes as Hydrophobic Pharmacophores: Applications for Design of Nuclear Receptor Ligands 3Yasuyuki Endo

1.2 Boron Cluster Modifications with Antiviral, Anticancer, and Modulation of Purinergic Receptors Activities Based on Nucleoside Structures 20Anna Adamska Bart omiejczyk, Katarzyna Bednarska, Magdalena Bia ek Pietras, Zofia M. Kilia ska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Miros awa Studzi ska, Zofia Su owska, Jolanta D. o nierczyk, and Zbigniew J. Lesnikowski

1.3 Design of Carborane Based Hypoxia Inducible Factor Inhibitors 35Guangzhe Li, Hyun Seung Ban, and Hiroyuki Nakamura

1.4 Half and Mixed Sandwich Transition Metal Dicarbollides and nido Carboranes( 1) for Medicinal Applications 60Benedikt Schwarze, Marta Gozzi, and Evamarie Hey Hawkins

1.5 Ionic Boron Clusters as Superchaotropic Anions: Implications for Drug Design 109Khaleel I. Assaf, Joanna Wilinska, and Detlef Gabel

1.6 Quantum Mechanical and Molecular Mechanical Calculations on Substituted Boron Clusters and Their Interactions with Proteins 126Jind ich Fanfrlík, Adam Pecina, Jan ezá , Pavel Hobza, and Martin Lep ík

Part 2 Boron Compounds in Drug Delivery and Imaging 139

2.1 Closomers: An Icosahedral Platform for Drug Delivery 141Satish S. Jalisatgi

2.2 Cobaltabisdicarbollide based Synthetic Vesicles: From Biological Interaction to in vivo Imaging 159Clara Viñas, Francesc Teixidor, and Adrian J. Harwood

2.3 Boronic Acid Based Sensor for Determination of Sugars 174Igor B. Sivaev and Vladimir I. Bregadze

2.4 Boron Compounds in Molecular Imaging 205Bhaskar C. Das, Devi Prasan Ojha, Sasmita Das, and Todd Evans

2.5 Radiolabeling Strategies for Boron Clusters: Toward Fast Development and Efficient Assessment of BNCT Drug Candidates 232Kiran B. Gona, Vanessa Gómez Vallejo, Irina Manea, Jonas Malmquist, Jacek Koziorowski, and Jordi Llop

Part 3 Boron Compounds for Boron Neutron Capture Therapy 269

3.1 Twenty Years of Research on 3 Carboranyl Thymidine Analogs (3CTAs): A Critical Perspective 271Werner Tjarks

3.2 Recent Advances in Boron Delivery Agents for Boron Neutron Capture Therapy (BNCT) 298Sunting Xuan and Maria da Graça H. Vicente

3.3 Carborane Derivatives of Porphyrins and Chlorins for Photodynamic and Boron Neutron Capture Therapies: Synthetic Strategies 343Valentina A. Ol shevskaya, Andrei V. Zaitsev, and Alexander A. Shtil

3.4 Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment 371Shanmin Gao, Yinghuai Zhu, and Narayan Hosmane

3.5 New Boronated Compounds for an Imaging–Guided Personalized Neutron Capture Therapy 389Nicoletta Protti, Annamaria Deagostino, Paolo Boggio, Diego Alberti, and Simonetta Geninatti Crich

3.6 Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies: Research in Animal Models Employing Different Boron Compounds and Administration Strategies 416Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Emiliano C.C. Pozzi, Elisa M. Heber, and Veronica A. Trivillin

Index

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Evamarie Hey–Hawkins
Clara Viñas Teixidor
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