The Liver: Oxidative Stress and Dietary Antioxidants takes a novel approach to the science of oxidative stress in liver disease by recognizing that diseases are multifactorial and oxidative stress is a single component. It highlights oxidative stress in relation to other processes, such as apoptosis, cell signaling and receptor mediated responses, and includes the therapeutic usage of natural antioxidants in the diet and food matrix, along with coverage of pharmacological and natural agents designed to counteract oxidative stress. Written for research scientists, gastroenterologists, food scientists, hepatologists and physicians, this trans-disciplinary guide will help advance medical sciences and enable new preventative and treatment strategies.
- Provides a framework for in-depth analysis of the basic processes of oxidative stress, from molecular biology, to whole organs in relation to the liver
- Bridges the trans-disciplinary divide between the basic science and mechanisms of liver disease and oxidative stress to advance medical sciences and enable preventative and treatment strategies
- Contains contributions from leading national and international experts, including those from world renowned institutions
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Oxidative Stress and the Liver 1. Oxidative stress in hepatitis C infection 2. Peroxidases and oxidative stress in fatty livers 3. Alterations in nucleocytoplasmic localization of the methionine cycle induced by oxidative stress during liver disease 4. Oxidative stress in iron toxicity of the liver 5. Cardiac glycosides and oxidative stress in liver cancer 6. Acetaldehyde effects on cellular redox state. 7. The role of glyoxalase-I in oxidant stress of liver damage 8. Antioxidants 1 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: an overview
Antioxidants and the Liver 9. Antioxidants 2 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of arginine and glutamine 10. Antioxidants 2 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of lipoic acid 11. Oxidative stress as crucial factor in liver disease: Potential Therapeutic effect of Antioxidants 12. L-NAME as a synthetic antioxidant in liver injury 13. Vitamin C, oxidative stress and liver protection 14. Lycopene, liver protection and oxidative stress 15. Vitamin E protection against hyperthyroidism-induced liver oxidative stress 16. Citric acid an antioxidant in liver 17. Resveratrol and protection in hepatic steatosis: antioxidant effects 18. Astaxanthin, a marine carotenoid against hepatic oxidative stress: A systematic review. 19. Effects of melatonin as an antioxidant in liver 20. Antioxidant role of the Mayan fruit canistel (Pouteria campechiana) in liver protection 21. Endogenous mitochondrial aldehyde dehydrogenase-2 as an antioxidant in liver 22. Comparing antioxidants in liver disease: L-carnitine, N-acetylcysteine and genistein 23. Coenzyme Q10, liver protection and oxidative stress 24. Carnosine as a putative antioxidant in usage against liver disease 25. Dioscin as a natural saponin and protection in oxidative stress in hepatic fibrosis 26. Gallic acid as a putative antioxidant in usage against liver disease 27. Oleuropein as an antioxidant and liver protection 28. Garlic and Liver Diseases
Dr Vinood B. Patel is a Senior Lecturer in Clinical Biochemistry at the University of Westminster and honorary fellow at King's College London. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death.
Dr. Patel's Scival overall research performance shows an h-index of 15, field-weighted citation impact of 6.16 with 3.3 citations per publication. He has published in 4 journal categories with the most contribution to both Medicine and Agriculture & Biological Science. Dr. Patel has an overall FWCI of 5.32 and averages 2.1 citations per publication from 2010-2014. The majority of his work has been split between Medicine and Agriculture & Biological Sciences. In the Medicine category alone he holds a FWCI of 10.
Dr Rajkumar Rajendram is a clinician scientist who has a focus is on anaesthesia, intensive care and peri-operative medicine. Dr Rajendram graduated in 2001 with a distinction from Guy's, King's and St. Thomas Medical School, in London. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram also trained in anaesthesia and intensive care in London and became a fellow of the Royal College of Anaesthetists (FRCA) in 2009. He has completed advanced training in regional anaesthesia and intensive care. He became a fellow of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014.
Dr Rajendram returned to Oxford as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford before moving to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram recognises that nutritional support is a fundamental aspect of medical care. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is a visiting lecturer in the Nutritional Sciences Research Division of King's College London and has published over 100 textbook chapters, review articles, peer-reviewed papers and abstracts.