Neurobiology of Abnormal Emotion and Motivated Behaviors. Integrating Animal and Human Research

Table of Contents

Introduction: Emotion and Motivated Behaviors: Integrating Animal and Human Neurobiology Research

Section 1: Emotion-­related impulsivity across disorders and species 1. Impulsive traits give rise to a wide range of maladaptive behaviors 2. Methods to develop a preclinical model of negative urgency 3. Mood-related impulsivity in the onset and course of mood disorders

Section 2: Impulsivity and stress in eating disorders 4. Trait impulsivity, stress reactivity, and disordered eating behavior 5. Etiology of eating disorders with an emphasis on genetic and neurobiological risk factors 6. Anorexic behavior 7. Eating disorders

Section 3: Interaction of stress and drug-seeking 8. Human bio-behavioral data delineating stress system sensitization as well as cognitive and emotional dysregulation during early abstinence from alcohol and cocaine 9. Interactions between stress- and drug-seeking behaviors 10. Synaptic mechanisms of the behavioral effects of alcohol

Section 4: Learning to inhibit the fear response 11. Insular and prefrontal cortex in aspects of stress mitigation, fear learning, and drug seeking 12. How anxiety affects social behaviors 13. Neural mechanisms of fear relapse 14. Overgeneralization of the fear response to stimuli that have never been associated with an aversive outcome

Section 5: Abnormal emotional reactivity versus regulation across disorders 15. Common affective symptoms that manifest in depression and schizophrenia 16. Abnormal processing of emotional information in major depression 17. Deficits in attention, cognitive control, and emotion regulation in schizophrenia 18. Cognitive impairment and affective deficits across depression and schizophrenia

Authors

Susan Sangha Assistant Professor, Behavioral Neuroscience, Department of Psychological Sciences, Purdue University, West Lafayette, Indiana, USA. Susan Sangha completed her PhD in neuroscience from the University of Calgary, Canada, in 2005 with funding from the Natural Sciences and Engineering Research Council of Canada and the Canadian Institutes of Health Research. She was a recipient of postdoctoral fellowship awards from the Natural Sciences and Engineering Research Council of Canada, the Alexander von Humboldt Foundation, and the Human Frontiers Science Program. Her research combines behavioral, pharmacological, and electrophysiological methods to investigate the neurobiological mechanisms underlying memory formation in animal models, with an emphasis on neural circuits of emotion. She is the author of more than 30 peer-reviewed articles and commentaries. Dan Foti Assistant Professor, Clinical Psychology, Department of Psychological Sciences, Purdue University, West Lafayette, Indiana, USA. Dan Foti received his undergraduate degree in biomechanical engineering from Harvard University and PhD in clinical psychology from Stony Brook University before completing his clinical internship at McLean Hospital. His research in humans uses methods from affective and cognitive neuroscience to study information-processing deficits in psychopathology, with a particular focus on mood and psychotic disorders. His research uses multimodal neuroimaging (event-related potentials, or ERPs; functional magnetic resonance imaging, or fMRI) to characterize neural activity involved in reward processing, emotion regulation, and cognition, and how deficits therein may be used to improve clinical judgments of diagnosis and prognosis. He was a recipient of an F-31 grant from the National Institute of Mental Health and a research training award from the Society for Psychophysiological Research. He has published widely, with more than 35 peer-reviewed articles to date in top clinical and neuroscience journals.