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Market Spotlight: Cervical Cancer

  • ID: 4421374
  • Report
  • 40 pages
  • Datamonitor Healthcare
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FEATURED COMPANIES

  • Amgen
  • AstraZeneca
  • Novarti
  • Pinnacle
  • Roche
  • MORE
This Market Spotlight report covers the cervical cancer market, comprising key pipeline and marketed drugs, clinical trials, upcoming events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts

Key Takeaways
  • The author estimates that in 2017, there were 564,900 incident cases of cervical cancer in females worldwide, and expects that number to increase to 618,400 incident cases by 2026.
  • Roche’s Avastin, Mylan’s biosimilar bevacizumab, and Amgen’s Mvasi, which target vascular endothelial growth factor; Novartis’s Hycamtin, a topoisomerase I inhibitor; Pinnacle’s Photofrin, a photodynamic therapy; and Merck’s Keytruda, an anti-PD-1 antibody, are the marketed drugs available for cervical cancer. The majority of marketed drugs are administered via the intravenous route.
  • The majority of industry-sponsored drugs in active clinical development for cervical cancer are in Phase II, with only two drugs in Phase III.
  • Therapies in mid-to-late-stage development for cervical cancer focus on a wide variety of targets. The majority of pipeline drugs in the cervical cancer space are administered via the intravenous route, with the remainder being oral, subcutaneous, intramuscular, and intranasal formulations.
  • The release of topline Phase III trial results for Libtayo is the only high-impact upcoming event in the cervical cancer space. The overall likelihood of approval of a Phase I solid tumors asset is 5.7%, and the average probability a drug advances from Phase III is 39.4%. Drugs, on average, take 9.5 years from Phase I to approval, compared to 9.2 years in the overall oncology space.
  • There have been 10 licensing and asset acquisition deals involving cervical cancer drugs during 2014–19. The $727.5m license agreement signed in 2015 between Inovio and MedImmune for the exclusive rights to develop and market Inovio's INO-3112 was the largest deal.
  • The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for cervical cancer have been in the early and mid-phases of development, with 95% of trials in Phase I–II, and only 5% in Phase III–IV.
  • The US has a substantial lead in the number of cervical cancer clinical trials globally. The UK leads the major EU markets, while South Korea has the top spot in Asia.
  • Clinical trial activity in the cervical cancer space is dominated by ongoing trials. AstraZeneca has the highest number of ongoing clinical trials for cervical cancer, with 14 trials.
  • AstraZeneca leads industry sponsors with the highest number of clinical trials for cervical cancer, followed by Roche.
Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Amgen
  • AstraZeneca
  • Novarti
  • Pinnacle
  • Roche
  • MORE
OVERVIEW

KEY TAKEAWAYS

DISEASE BACKGROUND

TREATMENT
Surgery
Radiotherapy
Chemotherapy
Targeted therapy

EPIDEMIOLOGY

MARKETED DRUGS

PIPELINE DRUGS

RECENT EVENTS AND ANALYST OPINION
Axalimogene Filolisbac for Cervical Cancer (January 23, 2019)
Axalimogene Filolisbac for cervical cancer (July 13, 2018)
Axalimogene Filolisbac for cervical cancer (March 9, 2018)
Imfinzi for cervical cancer (March 9, 2018)
Mvasi for cervical cancer (October 17, 2017)

KEY UPCOMING EVENTS
PROBABILITY OF SUCCESS

LICENSING AND ASSET ACQUISITION DEALS
Advaxis Stumbles Further As Amgen Exits Early-Stage Cancer Immunotherapy Pact

PARENT PATENTS

REVENUE OPPORTUNITY

CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase

BIBLIOGRAPHY
Prescription information

APPENDIX

LIST OF FIGURES
Figure 1: Trends in incident cases of cervical cancer, 2017–26
Figure 2: Overview of pipeline drugs for cervical cancer in the US
Figure 3: Pipeline drugs for cervical cancer, by company
Figure 4: Pipeline drugs for cervical cancer, by drug type
Figure 5: Pipeline drugs for cervical cancer, by classification
Figure 6: Key upcoming events in cervical cancer
Figure 7: Probability of success in the cervical cancer pipeline
Figure 8: Licensing and asset acquisition deals in cervical cancer, 2014–19
Figure 9: Parent patents in cervical cancer
Figure 10: Clinical trials in cervical cancer
Figure 11: Top 10 drugs for clinical trials in cervical cancer
Figure 12: Top 10 companies for clinical trials in cervical cancer
Figure 13: Trial locations in cervical cancer
Figure 14: Cervical cancer trials status
Figure 15: Cervical cancer trials sponsors, by phase

LIST OF TABLES
Table 1: Incident cases of cervical cancer, 2017–26
Table 2: Marketed drugs for cervical cancer
Table 3: Pipeline drugs for cervical cancer in the US
Table 4: Axalimogene Filolisbac for Cervical Cancer (January 23, 2019)
Table 5: Axalimogene Filolisbac for cervical cancer (July 13, 2018)
Table 6: Axalimogene Filolisbac for cervical cancer (March 9, 2018)
Table 7: Imfinzi for cervical cancer (March 9, 2018)
Table 8: Mvasi for cervical cancer (October 17, 2017)
Table 9: Historical global sales, by drug ($m), 2013–17
Table 10: Forecasted global sales, by drug ($m), 2019–23
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  • Novarti
  • Roche
  • Amgen
  • AstraZeneca
  • Pinnacle
Note: Product cover images may vary from those shown
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