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Market Spotlight: Neuropathic Pain

  • ID: 4421386
  • Report
  • September 2020
  • Region: Global
  • 35 pages
  • Datamonitor Healthcare

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FEATURED COMPANIES

  • Allergan
  • Depomed
  • Janssen
  • Pfizer
  • MORE
This Market Spotlight report covers the neuropathic pain market, comprising key marketed and pipeline drugs, recent events and analyst opinion, clinical trials, upcoming events, probability of success, patent information, a 10-year disease prevalence forecast, and licensing and asset acquisition deals, as well as presenting drug-specific revenue forecasts.

Key Takeaways
  • The publisher estimates that in 2017, there were 425.2 million prevalent cases of neuropathic pain in adults aged 20 years and older worldwide, and forecasts that number to increase to 476.2 million prevalent cases by 2026.
  • Asia is estimated to have had the largest number of prevalent cases in 2017, driven by population size, while having the lowest prevalence proportion (98.1 million cases; 3.2%).
  • The marketed drugs in the neuropathic pain space target sodium channels, voltage-gated calcium channels, and transient receptor potential vanilloid receptor 1. These drugs are administered via the oral route, except for Qutenza, which is available as a topical formulation.
  • The majority of industry-sponsored drugs in active clinical development for neuropathic pain are in Phase I. Therapies in development for neuropathic pain focus on a wide variety of targets. The majority of pipeline drugs in early- and mid-stage development are administered orally, with the remainder being intramuscular, intrathecal, intradermal, subcutaneous, and topical formulations.
  • High-impact upcoming events for drugs in the neuropathic pain space comprise topline Phase IIa trial results for AP-325, topline Phase II trial results for vixotrigine and Dysport, and topline Phase III trial results for DS-5565.
  • The overall likelihood of approval of a Phase I neuropathic pain asset is 0.7%, and the average probability a drug advances from Phase III is 33.3%. Drugs, on average, take 8.9 years from Phase I to approval, compared to 9.8 years in the overall neurology space.
  • The distribution of clinical trials across Phase I–IV indicates that the majority of trials have been in the early and mid-phases of development, with 70% of trials in Phase I–II, and only 30% in Phase III–IV.
  • The US has a substantial lead in the number of neuropathic pain clinical trials globally. The UK leads the major European markets, while Japan has the top spot in Asia.
  • Clinical trial activity in the neuropathic pain space is dominated by completed trials. Pfizer has the highest number of completed clinical trials for neuropathic pain, with 237 trials.
  • Pfizer leads industry sponsors with by far the highest overall number of clinical trials for neuropathic pain, followed by AbbVie.
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • Allergan
  • Depomed
  • Janssen
  • Pfizer
  • MORE
Overview

Key Takeaways

Disease Background
  • Subtypes
Treatment
  • Antidepressants
  • Antiepileptics
  • Cannabinoids
  • Opioids
  • Topical or focal therapies
Epidemiology
  • Limitations of neuropathic pain prevalence estimates
Marketed Drugs

Pipeline Drugs

Key Upcoming Events

Key Regulatory Events
  • Sun Targets US Long-Term Care And Eye Care
  • Abbott Wins FDA Approval For 'Low Dose' Non-Rechargeable Spinal Cord Stimulator
Probability of Success

Licensing and Asset Acquisition Deals
  • VistaGen Therapeutics to partner with Nuformix
Revenue Opportunity

Clinical Trial Landscape
  • Sponsors by status
  • Sponsors by phase
Bibliography
  • Prescription information
Appendix

List of Figures
  • Figure 1: Trends in prevalent cases of neuropathic pain, 2017–26
  • Figure 2: Overview of pipeline drugs for neuropathic pain in the US
  • Figure 3: Pipeline drugs for neuropathic pain, by company
  • Figure 4: Pipeline drugs for neuropathic pain, by drug type
  • Figure 5: Pipeline drugs for neuropathic pain, by classification
  • Figure 6: Key upcoming events in neuropathic pain
  • Figure 7: Probability of success in the neuropathic pain pipeline
  • Figure 8: Clinical trials in neuropathic pain
  • Figure 9: Top 10 drugs for clinical trials in neuropathic pain
  • Figure 10: Top 10 companies for clinical trials in neuropathic pain
  • Figure 11: Trial locations in neuropathic pain
  • Figure 12: Neuropathic pain trials status
  • Figure 13: Neuropathic pain trials sponsors, by phase
List of Tables
  • Table 1: Prevalence methodology
  • Table 2: Prevalent cases of neuropathic pain, 2017–26
  • Table 3: Prevalence proportions of neuropathic pain, 2017–26
  • Table 4: Marketed drugs for neuropathic pain
  • Table 5: Pipeline drugs for neuropathic pain in the US
  • Table 6: Historical global sales, by drug ($m), 2015–19
  • Table 7: Forecasted global sales, by drug ($m), 2020–24
Note: Product cover images may vary from those shown
  • Allergan
  • Depomed
  • Janssen
  • Pfizer
Note: Product cover images may vary from those shown
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