Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science.
Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers.
- Provides a comprehensive view of polyunsaturated fatty acid metabolism
- Describes underlying metabolism on lipids that include polyunsaturated fatty acids
- Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism
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2. Polyunsaturated fatty acid biosynthesis in fish -an overview
3. Polyunsaturated fatty acid biosynthesis in birds
4. Biochemistry and regulation of delta-6 and delta-5 desaturases in animals
5. Biochemistry and regulation of elongase 2 and 5 in mammals
6. Polyunsaturated fatty acid biosynthesis in infancy
7. Alternative pathways of polyunsaturated fatty acid biosynthesis in eukaryotes
8. Endocrine influences on polyunsaturated fatty acid biosynthesis
9. Dietary modification of polyunsaturated fatty acid biosynthesis
10. Genetic influences on polyunsaturated fatty acid biosynthesis
11. Epigenetic influences on polyunsaturated fatty acid biosynthesis
12. Implications of polyunsaturated fatty acid metabolism for human health
Professor Burdge has over 25 years' experience of research into lipid metabolism, in particular polyunsaturated fatty acids (PUFA) including having demonstrated that maternal PUFA biosynthesis increases during pregnancy to raise docosahexaenoic acid (DHA) status in order to ensure adequate supply to the offspring, and identifying sex differences in DHA status in a number of species, and characterizing underlying biochemical and molecular mechanisms. His current research focus is the interaction between lipids and the epigenome. He has 10 years editorial experience including serving for the past three years as the Editor-in-Chief of the British Journal of Nutrition and of the Journal of Nutritional Science.