We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases.
Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution.
- Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine- Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine- Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter- Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way- Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field
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1. Introduction: Seriously, What is Precision Medicine? 2. Redefining Disease Causality 3. Genetics: Clues, Not Answers, to the Mysteries of Precision Medicine 4. Disease Convergence 5. The Precision of the Rare Diseases 6. Precision Organisms 7. Reinventing Diagnosis 8. Precision Data 9. Impersonalized Precision Medicine 10. The Alternate Futures of Precision Medicine