Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more.
- Helps readers understand the wide array of topics surrounding anesthesia
- Includes sections on Pharmacophore QSAR, QM, ONIOM, and the kinetic modeling of electrophysiology data
- Broaches genetics, model organisms and general genetic strategies
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Computational approaches 1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics 2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics 3. Anesthetic parameterization 4. Pharmacophore QSAR, QM, ONIOM 5. Kinetic modeling of electrophysiology data
Genetics and model organisms 6. General genetic strategies 7. Worms 8. Flies 9. Tadpoles 10. Zebrafish 11. Mice
Photolabeling 12. Mass spect ID of adducts 13. Photolabeling protection/competition
Xenon 14. Xenon-protein interactions 15. Xenon gas delivery/recovery procedures 16. Hyperpolarized Xe-129 MRI 17. CT imaging
Electrophysiology 18. Native system electrophysiology (slices, cells, in vivo) 19. Voltage-gated ion channels (Kv, Nav) 20. Ligand-gated ion channels 21. Other channels (HCN/K2P/TRP)
Structural Approaches 22. Soluble proteins 23. Membrane proteins 24. NMR 25. Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels
Evolving Biophysical Technologies 26. Fluorescent Anesthetics 27. Investigation of anesthetic-protein interactions by a thermodynamic approach 28. Tissue/organism EPR 29. Lipids, Membranes and Pressure reversal
In vivo technologies; established and evolving 30. Optoanesthesia 31. Optogenetics, Chemogenetics 32. Genetic reporters of neuronal activity: c-fos, genetically encoded calcium indicators 33. Genomics and Proteomic Techniques 34. Neurochemistry of Anesthetic States 35. Electroencephalography 36. PET 37. Drug discovery and development 38. The use of glutamatergic anesthetics (ketamine, nitrous oxide and xenon) in depression 39. Brain Imaging Using Hyperpolarized 129Xe MRI