Emerging Nanotechnologies in Immunology: The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanopharmaceuticals currently in the pipeline of S&T development for skin, ocular and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The book's contributors address a representative set of the broad spectrum of nanopharmaceutics presently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue-engineered skin substitutes.
In addition, regulation and risk are also covered since the safety of these nanopharmaceuticals still represents a barrier to their wide and innovative use.
- Provides a thorough knowledge of the safety aspects of nanopharmaceuticals currently under research
- Focuses on the characterization and quantification of nanopharmaceutics to allow readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects
- Includes a thorough overview of legal and regulatory aspects and a discussion of the ethical issues related to the R&D of nanopharmaceuticals
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1. Nanopharmaceutics in immunology: what's new in research? Ranjita Shegokar, Ana Rita Fernandes and Eliana Souto 2. Skin delivery of antimicrobial peptides Monika Schaefer-Korting and Jens Rolff 3. Skin penetration of nanoparticles Shohreh Nafisi and Howard I. Maibach 4. Regulatory and risk assessment perspective for Core-Multishell Nanocarriers: A novel excipient on its way towards marketing authorization Sam D. More, Margret More, Florian Paulus, Emanuel Fleige amd Marcin Libera 5. Anti-inflammatory drugs: Pharmaceutical Nanotechnology approach Andjelka B. Kovacevic, Sergio M.C.Silva and Slavomira Doktorovova 6. New strategies for the treatment of auto-immune diseases using nanotechnologies Amelia M. Silva, Joao R. Siopa, Carlos Martins-Gomes, Maria C. Teixeira, Dario J. Santos, Maria dos Anjos Pires and Tatiana Andreani 7. Nanopharmaceutics Applications in Inhaler Systems Aysu Yurdasiper, Mesut Arici and Mine Ozyazici 8. Immunomodulatory Effects of Curcumin in infectious and non-infectious diseases Ranjita Shegokar 9. Advances in Antibiotic Nanotherapy: Overcoming Antimicrobial Resistance Teixeira, M.C., Sanchez-Lopez, E., Espina, M., Calpena, A.C., Silva, A.M., Veiga, F.J., Garcia, M. L., Souto, E.B.
Dr. Shegokar holds a Ph.D. degree in Pharmaceutical Technology from the SNDT University, India and has been postdoctoral researcher at Free University of Berlin, Department of Pharmaceutical Technology, Biopharmaceutics and NutriCosmetics, Berlin, Germany. Since last 6 years she is working for pharmaceutical industry in various technical / R & D roles. Currently, she serves as Head of Formulation Development department at Symrise AG, Germany. Dr. Shegokar has authored more than 45 research articles, 20 book chapters and 150 research abstracts. She has filed two patent applications on nanoparticles for targeting malaria and HIV/AIDS reservoirs and have 2 other application in area of active delivery. She is a recipient of several national and international awards for her research. Her areas of interest are oral solid dosage forms, dermal formulations, nanocrystals, lipid nanoparticles (SLNs/NLCs), nanoemulsions and galenic formulations.
Souto, Eliana B.
Prof. Eliana B. Souto (Souto, E.B.) is affiliated with the Department of Pharmaceutical Technology of the Faculty of Pharmacy, University of Coimbra, Portugal. Eliana is graduated in Pharmaceutical Sciences from the same University (2000). She holds a Master in Science degree in Pharmaceutical Technology and Pharmacotechnique from the Faculty of Pharmacy, University of Porto (2002), and the PhD in Pharmaceutical Technology, Biopharmaceutics and Biotechnology from the Institut fuer Pharmazie der Freie Universitaet Berlin, Germany (2005). Since August 2012, Eliana Souto holds the Habilitation Degree (dr. Habil.) from the University Fernando Pessoa (Porto). Her research lines focus on the design, development, and characterization of new drug delivery systems. Other research interests include the controlled delivery of drugs across biological barriers, with especial emphasis for ocular and skin administration. Eliana Souto is Associate Editor, member of the Editorial Board, and reviewer of several international scientific journals. She counts with more than 400 scientific publications in the field of Nanosciences and Nanotechnologies.