Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

  • ID: 4454878
  • Book
  • 400 Pages
  • John Wiley and Sons Ltd
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Written by a team of world–class leaders from academia and industry, this is a unique overview of the most important protecting group strategies in modern carbohydrate chemistry.

Clearly divided into two parts, the first focuses on those groups best used to protect a specific position on a carbohydrate. The second part then discusses specific carbohydrate residues or compounds in the context of a protecting group strategy used to reach the desired regioisomer. The whole is rounded off by chapters on case studies and industrial scale synthesis of oligosaccharides through modern protecting group chemistry.

By providing strategies and synthetic applications, this is an indispensable guide for both beginners and specialists working in carbohydrate synthesis, natural product chemistry, pharmaceutical chemistry, and biochemistry.
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1) Protecting Groups at the Primary Position of Carbohydrates

2) Protecting Groups at the Secondary Position of Carbohydrates

3) Protecting Groups at the Anomeric Position of Carbohydrates

4) Strategies Towards Protection of 1,2– and 1,3–Diols

5) Protection of the Amine Functionality in Amino–Glycosides

6) Protecting Group Strategies for Glycuronic Acids

7) Protecting Group Strategies for Sialic Acid Derivatives

8) Protecting Group Strategies for Cyclodextrins

9) Protecting Group Strategies towards Glycofuranoses

10) Protecting Group Strategies towards Sulfated Glycosaminoclycans

11) A Case Study of Protecting Groups for the Synthesis of a Vaccine Antigen

12) Application of Ionic Liquid and Fluorous Tags for Oligosaccharide Synthesis

13) Acyl Migrations in Carbohydrate Chemistry

14) Orthogonally Protected Monosaccharides and Industrial Applications in Solid Phase Synthesis

15) Industrial Scale Synthesis of Oligosaccharides through Modern Protecting Group Chemistry

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Sébastien Vidal holds a CNRS position at the University of Lyon, France. He received his PhD in Organic Chemistry from the University of Montpellier (France, 2000) under the direction of Prof. J.–L. Montero. He then moved to the group of Sir J. F. Stoddart at the University of California, Los Angeles, as a postdoctoral fellow. In 2003, he moved to the National Renewable Energy Laboratory (NREL) in Golden (USA) to study with Prof. J. J. Bozell the combination of organometallic and carbohydrate chemistries for the design of new reactions. He joined the group of Prof. P. G. Goekjian at the University of Lyon in 2004 where he started his own research projects dealing with carbohydrate chemistry and applications in biology. The main topics covered in his research are the design of glycoclusters for anti–adhesive strategy against bacterial infections but also enzyme inhibitors targeting glycogen phosphorylase with applications in type 2 diabetes In 2014 he was endowed the young investigator award "Prix du Groupe Français des Glycosciences".
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