Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder.
Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.
- Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry
- Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system
- Explores translational potential of targeting immune dysfunction for clinical interventions
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7. The Roles of T Cells in Clinical Depression CATHERINE TOBEN, BERNHARD T. BAUNE 8. Do Chemokines Have a Role in the Pathophysiology of Depression? GAURAV SINGHAL, BERNHARD T. BAUNE 9. Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression GAURAV SINGHAL, BERNHARD T. BAUNE 10. Pathways Driving Neuroprogression in Depression: The Role of Immune Activation GIOVANNI ORIOLO, IRIA GRANDE, ROCI´O MARTIN-SANTOS, EDUARD VIETA, ANDR 11. Gene Expression of Inflammation Markers in Depression LILIANA G. CIOBANU, BERNHARD T. BAUNE 12. Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression JOSHUA HOLMES, FRANCES CORRIGAN, MARK HUTCHINSON 13. The Gut-Brain-Microbe Interaction: Relevance in Inflammation and Depression NATALIE PARLETTA 14. Childhood Trauma and Adulthood Immune Activation MARIA A. NETTIS, VALERIA MONDELLI 15. Stress, Maltreatment, Inflammation, and Functional Brain Changes in Depression KELLY DOOLIN, LEONARDO TOZZI, JOHANN STEINER, THOMAS FRODL 16. Structural Neuroimaging of Maltreatment and Inflammation in Depression RONNY REDLICH, NILS OPEL, KATHARINA F FÖRSTER, JENNIFER ENGELEN, UDO DANNLOWSKI 17. Biological Embedding of Childhood Maltreatment in Adult Depression MAGDALENE C. JAWAHAR, BERNHARD T. BAUNE 18. Epigenetic Changes in the Immune Systems Following Early-Life Stress CHRIS MURGATROYD 19. Mechanisms Linking Depression, Immune System and Epigenetics During Aging STEVEN BRADBURN 20. Role of Inflammation in Neuropsychiatric Comorbidity of Obesity: Experimental and Clinical Evidence C 21. Inflammation and Depression in Patients With Autoimmune Disease, Diabetes, and Obesity JONATHAN M. GREGORY, MICHAEL MAK, ROGER S. MCINTYRE 22. Does Inflammation Link Clinical Depression and Coronary Artery Disease? SILKE J JÖRGENS, VOLKER AROLT 23. Inflammation Genetics of Depression MICHAEL MUSKER, JULIO LICINIO, MA-LI WONG 24. Adolescent-Onset Depressive Disorders and Inflammation IAN HICKIE, JOANNE CARPENTER, ELIZABETH SCOTT 25. Inflammation in Bipolar Disorder JOSHUA D. ROSENBLAT, JONATHAN M. GREGORY, SOPHIE FLOR-HENRY, ROGER S. MCINTYRE 26. Depression Subtypes and Inflammation: Atypical Rather Than Melancholic Depression Is Linked With Immunometabolic Dysregulations FEMKE LAMERS, YURI MILANESCHI, BRENDA W.J.H. PENNINX 27. Inflammation as a Marker of Clinical Response to Treatment: A Focus on Treatment-Resistant Depression REBECCA STRAWBRIDGE, ALLAN H. YOUNG, ANTHONY J. CLEARE 28. Clinical Trials of Anti-Inflammatory Treatments of Major Depression? NORBERT MÜLLER 29. Alcohol, Inflammation, and Depression: The Gut-Brain Axis ABIGAIL R. CANNON, ADAM M. HAMMER, MASHKOOR A. CHOUDHRY 30. Efficacy of Anti-Inflammatory Treatment in Depression OLE KÖHLER-FORSBERG, MICHAEL ERIKSEN BENROS 31. Modulation of Inflammation by Antidepressants BERNHARD T. BAUNE 32. The Biological Underpinnings of Mood Disorders Interact With Early Trauma, Sexual Abuse and Neuroticism: Implications for Psychiatric Classification and Treatment GEORGE ANDERSON, MICHAEL MAES 33. Is There Still Hope for Treating Depression With Antiinflammatories? BERNHARD T. BAUNE 34. Effects of Physical Exercise on Inflammation in Depression HARRIS A. EYRE, KATARINA ARANDJELOVIC, DAVID A MERRILL, AJEET B SINGH, HELEN LAVRETSKY 35. Future Perspectives on Immune-Related Treatments BERNHARD T. BAUNE
Professor Baune is Chair of Psychiatry and Head of the Discipline of Psychiatry at the University of Adelaide, Australia, and is a specialist psychiatrist internationally recognized for his work in the field of depression. He was the first researcher to link inflammation genetics with brain function (fMRI) and clinical treatment response, and has done significant work on the role of inflammatory and immunological genetic and non-genetic markers in various psychiatric conditions. He is the author of more than 420 peer-reviewed publications in such journals as The New England Journal of Medicine, The Lancet, Nat Genetics, JAMA Psychiatry and Mol Psychiatry.