Inflammation and Immunity in Depression

  • ID: 4454945
  • Book
  • 636 Pages
  • Elsevier Science and Technology
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Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder.

Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.

  • Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry
  • Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system
  • Explores translational potential of targeting immune dysfunction for clinical interventions

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7. The Roles of T Cells in Clinical Depression

CATHERINE TOBEN, BERNHARD T. BAUNE

8. Do Chemokines Have a Role in the Pathophysiology of Depression?

GAURAV SINGHAL, BERNHARD T. BAUNE

9. Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression

GAURAV SINGHAL, BERNHARD T. BAUNE

10. Pathways Driving Neuroprogression in Depression: The Role of Immune Activation

GIOVANNI ORIOLO, IRIA GRANDE, ROCI´O MARTIN-SANTOS, EDUARD VIETA, ANDR

11. Gene Expression of Inflammation Markers in Depression

LILIANA G. CIOBANU, BERNHARD T. BAUNE

12. Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression

JOSHUA HOLMES, FRANCES CORRIGAN, MARK HUTCHINSON

13. The Gut-Brain-Microbe Interaction: Relevance in Inflammation and Depression

NATALIE PARLETTA

14. Childhood Trauma and Adulthood Immune Activation

MARIA A. NETTIS, VALERIA MONDELLI

15. Stress, Maltreatment, Inflammation, and Functional Brain Changes in Depression

KELLY DOOLIN, LEONARDO TOZZI, JOHANN STEINER, THOMAS FRODL

16. Structural Neuroimaging of Maltreatment and Inflammation in Depression

RONNY REDLICH, NILS OPEL, KATHARINA F FÖRSTER, JENNIFER ENGELEN, UDO DANNLOWSKI

17. Biological Embedding of Childhood Maltreatment in Adult Depression

MAGDALENE C. JAWAHAR, BERNHARD T. BAUNE

18. Epigenetic Changes in the Immune Systems Following Early-Life Stress

CHRIS MURGATROYD

19. Mechanisms Linking Depression, Immune System and Epigenetics During Aging

STEVEN BRADBURN

20. Role of Inflammation in Neuropsychiatric Comorbidity of Obesity: Experimental and Clinical Evidence

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21. Inflammation and Depression in Patients With Autoimmune Disease, Diabetes, and Obesity

JONATHAN M. GREGORY, MICHAEL MAK, ROGER S. MCINTYRE

22. Does Inflammation Link Clinical Depression and Coronary Artery Disease?

SILKE J JÖRGENS, VOLKER AROLT

23. Inflammation Genetics of Depression

MICHAEL MUSKER, JULIO LICINIO, MA-LI WONG

24. Adolescent-Onset Depressive Disorders and Inflammation

IAN HICKIE, JOANNE CARPENTER, ELIZABETH SCOTT

25. Inflammation in Bipolar Disorder

JOSHUA D. ROSENBLAT, JONATHAN M. GREGORY, SOPHIE FLOR-HENRY, ROGER S. MCINTYRE

26. Depression Subtypes and Inflammation: Atypical Rather Than Melancholic Depression Is Linked With Immunometabolic Dysregulations

FEMKE LAMERS, YURI MILANESCHI, BRENDA W.J.H. PENNINX

27. Inflammation as a Marker of Clinical Response to Treatment: A Focus on Treatment-Resistant Depression

REBECCA STRAWBRIDGE, ALLAN H. YOUNG, ANTHONY J. CLEARE

28. Clinical Trials of Anti-Inflammatory Treatments of Major Depression

NORBERT MÜLLER

29. Alcohol, Inflammation, and Depression: The Gut-Brain Axis

ABIGAIL R. CANNON, ADAM M. HAMMER, MASHKOOR A. CHOUDHRY

30. Efficacy of Anti-Inflammatory Treatment in Depression

OLE KÖHLER-FORSBERG, MICHAEL ERIKSEN BENROS

31. Modulation of Inflammation by Antidepressants

BERNHARD T. BAUNE

32. The Biological Underpinnings of Mood Disorders Interact With Early Trauma, Sexual Abuse and Neuroticism: Implications for Psychiatric Classification and Treatment

GEORGE ANDERSON, MICHAEL MAES

33. Is There Still Hope for Treating Depression With Antiinflammatories?

BERNHARD T. BAUNE

34. Effects of Physical Exercise on Inflammation in Depression

HARRIS A. EYRE, KATARINA ARANDJELOVIC, DAVID A MERRILL, AJEET B SINGH, HELEN LAVRETSKY

35. Future Perspectives on Immune-Related Treatments

BERNHARD T. BAUNE

Index

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Baune, Bernhard
Professor Baune is Chair of Psychiatry and Head of the Discipline of Psychiatry at the University of Adelaide, Australia, and is a specialist psychiatrist internationally recognized for his work in the field of depression. He was the first researcher to link inflammation genetics with brain function (fMRI) and clinical treatment response, and has done significant work on the role of inflammatory and immunological genetic and non-genetic markers in various psychiatric conditions. He is the author of more than 420 peer-reviewed publications in such journals as The New England Journal of Medicine, The Lancet, Nat Genetics, JAMA Psychiatry and Mol Psychiatry.
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