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Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.
- Provides extended, timely reviews of topics in medicinal chemistry
- Contains targets and technologies relevant to the discovery of tomorrow's drugs
- Presents analyses of successful drug discovery programs
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1. Discovery and Development of Calcimimetic and Calcilytic Compounds Edward F. Nemeth, Bradford C. Van Wagenen and Manuel F. Balandrin 2. VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine) Nicole D. Harriott, John P. Williams, Evan B. Smith, Haig P. Bozigian and Dimitri E. Grigoriadis 3. Current Trends in Macrocyclic Drug Discovery and Beyond-Ro5 Sulejman Alihodzic, Mirjana Bukvic, Ivaylo J. Elenkov, Antun Hutinec, Sanja Kostrun, Dijana Pesic, Gordon Saxty, Linda Tomaskovic and Dinko Ziher 4. Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR Phil R. Kym, Xueqing Wang, Mathieu Pizzonero and Steven E. Van der Plas 5. Big Data in Drug Discovery Nathan Brown, Jean Cambruzzi, Peter J. Cox, Mark Davies, James Dunbar, Dean Plumbley, Matthew A. Sellwood, Aaron Sim, Bryn I. Williams-Jones, Magdalena Zwierzyna and David W. Sheppard
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