Vitiligo. Medical and Surgical Management

  • ID: 4458608
  • Book
  • 536 Pages
  • John Wiley and Sons Ltd
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PRACTICAL GUIDANCE BASED ON EXPERT EXPERIENCE AND EVIDENCE FOR DEVELOPING MANAGEMENT STRATEGIES FOR VITILIGO

This complete guide to vitiligo provides a full appraisal of strategy for the treatment of this autoimmune disease that affects 1–2% of the world′s population. It addresses all aspects of vitiligo, covering the science, medical and surgical therapies, and the psychological evaluations and approaches based on the proper understanding of the causes and classification of a particular case.

Management of vitiligo is challenging and requires a multipronged approach. Vitiligo: Medical and Surgical Management is a comprehensive, timely, state–of–the–art resource that will help those involved with affected patients better understand and treat this disease, which takes its toll on the mental wellness of those afflicted by it. Vitiligo: Medical and Surgical Management takes an evidenced–based approach to the disease′s treatment; provides an overview of the surgical management; covers tissue and cellular grafting; and more.

  • Thoroughly guides those involved in the clinical aspects of vitiligo
  • Aids diagnosis and classification of severity
  • Balances evidence and experience
  • Compiled by world–leading expert editors

Comprehensive in nature, Vitiligo: Medical and Surgical Management contains a strong practical element, and is a welcome go–to source for practicing dermatologists and those training to become a dermatologist.

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List of Contributors xiii

Foreword xix

Preface xxi

About the Companion Website xxiii

Section 1 Basic Science 1

1 Introduction 3Somesh Gupta and Nanja van Geel

2 Melanocyte and Melanogenesis: Applied Anatomy and Physiology 9Reinhart Speeckaert and Nanja van Geel

3 Epidemiology of Vitiligo 15Nader AboulFettouh and Amit G. Pandya

4 Pathogenesis of Vitiligo 19John E. Harris

5 Understanding the Mechanisms of Repigmentation in Vitiligo 27Ravinder Kumar, Davinder Parsad, and Amrinder J. Kanwar

Section 2 Clinical Science 33

6 Classification and Clinical Features of Vitiligo 35Sang Ho Oh and SeungKyung Hann

7 Outcome Measures for Vitiligo 49Brian Clinton, Viktoria Eleftheriadou, Nanja van Geel, Laila Benzekri, Amit G. Pandya, and Khaled Ezzedine

8 Evaluation and Treatment of the Psychosocial Burden of Vitiligo 61Vishal Gupta and M. Ramam

9 Patient Support, Education, and Compliance 69Richard H. Huggins, Jackie Gardner, and Amit G. Pandya

10 Goals of Vitiligo Treatment, and Evidence Based Practice Guidelines for Medical and Surgical Management 77Kevin Prier and Amit G. Pandya

11 The Concept of Stability of Vitiligo and Stabilization Therapies 81Anuradha Bishnoi and Davinder Parsad

Section 3 Phototherapy 91

12 Narrow Band Ultraviolet B Phototherapy in Vitiligo 93Narumol Silpaarcha and Henry W. Lim

13 UVA Based Phototherapy: PUVA, PUVA Sol, and UVA1 Phototherapy 105Ljubomir B. Novakovi

14 Targeted Phototherapy in Vitiligo 113Mohammed AlJamal, James L. Griffith, Iltefat H. Hamzavi, and Henry W. Lim

Section 4 Medical Management 123

15 Immunomodulators and Immunosuppressives in Vitiligo Treatment 125Anuradha Bishnoi and Davinder Parsad

16 Topical Glucocorticoids, Topical Calcineurin Inhibitors, and Topical Vitamin D3 Analogs 133Sai Yee Chuah and Boon Kee Goh

17 Other Therapies in Vitiligo 141Narumol Silpaarcha, James L. Griffith, Iltefat H. Hamzavi, and Pearl E. Grimes

18 Biologic Therapies for Vitiligo 151Pablo Michel and Amit G. Pandya

19 Evidence Toward Integrated Management of Vitiligo, Combining Ayurveda and Homeopathy with Modern Dermatology 159Saravu R. Narahari, Madhur G. Aggithaya, Kuthaje S. Bose, and Kodimoole S. Prasanna

Section 5 Surgical Therapies: History, Patient Selection, and Classification 171

20 History and Chronology of Development of Surgical Therapies for Vitiligo 173Koushik Lahiri and Abhishek De

21 Patient Selection, Pre and Postoperative Information in Surgical Therapies for Vitiligo 185Nanja van Geel and Mats J. Olsson

22 Classification of Surgical Therapies in Vitiligo 193James L. Griffith, Mohammed AlJamal, and Iltefat H. Hamzavi

Section 6 Surgical Therapies: Tissue Grafting 209

23 Minigrafting for Vitiligo 211Koushik Lahiri

24 Suction Blister Epidermal Grafting 225Savita Yadav and Somesh Gupta

25 Thin and Ultra Thin Skin Grafts for Vitiligo 241Imran Majid

26 Treatment of Leukoderma by Transplantation of Ultra Thin Epidermal Sheets
Using a Motorized Dermatome 249Mats J. Olsson

27 Mesh Grafts for Vitiligo 257Chakravarthi R. Srinivas and Reena Rai

28 Smash Grafting 261Sumit Kar, Ajay Krishnan, and Sudhir Singh

29 Therapeutic Needling and Needling Micrografting 267Khalifa E. Sharquie and Adil A. Noaimi

30 Complications and Limitations of Melanocyte Transplantation 273Yvon Gauthier and Laila Benzekri

Section 7 Surgical Therapies: Cellular Grafting 279

31 Treatment of Leukoderma by Transplantation of Basal Cell Layer Suspension 281Mats J. Olsson

32 Non Cultured Extracted Follicle Outer Root Sheath Cell Suspension Transplantation 293Kanika Sahni and Somesh Gupta

33 Long Term Results of Non Cultured Epidermal Cellular Grafting in Vitiligo 299Nanja van Geel, Sofie De Schepper, Hilde Lapeere, Barbara Boone, Boon Kee Goh, and Reinhart Speeckaert

34 Simplified Non Cultured Cellular Grafting 303Boon Kee Goh

35 Novel Methods of Preparing Epidermal Cell Suspension for Transplantation in Vitiligo 309Vishal Gupta, Sanjeev Gupta, Kanika Sahni, and Somesh Gupta

36 Management of Vitiligo: Setting Up a Tissue Culture Laboratory 317Rafa Czajkowski, Ma gorzata Maj, and Tomasz Drewa

37 Treatment of Leukoderma by Transplantation of Cultured Autologous Melanocytes 323Mats J. Olsson

38 Transplantation of In Vitro Cultured Epithelial Grafts for Vitiligo and Piebaldism 337Liliana Guerra, Sergio Bondanza, and Desanka Raskovic

39 Application of Lasers for Abrasion in Transplantation Procedures for Vitiligo 351Gwang Seong Choi

40 Cell Delivery on Recipient Skin 357Thomas Hunziker

41 Safety Concerns in Transplantation of In Vitro Cultured Cellular Grafts 363Liliana Guerra, Elena Dellambra, Patrizia Paterna, and Somesh Gupta

Section 8 Special Issues in Medical and Surgical Therapies 369

42 Surgical Management of Vitiligo of Lips, Eyelids, and Genitals 371Riti Bhatia and Somesh Gupta

43 Surgical Management of Acral Vitiligo 389Munish Paul

44 Surgical Management of Leukotrichia 401Amrendra Kumar

45 Surgical Treatments of Leukodermas Other Than Vitiligo Vulgaris 407Mats J. Olsson

46 Ethnic Issues in Management of Vitiligo and Sun Protection 417Haneol S. Jeong, Michelle Rodrigues, and Amit G. Pandya

47 Management Issues for Vitiligo in Children and Pregnant Women 427Freya Van Driessche and Nanette Silverberg

48 Combination Treatments for Vitiligo 439Anuradha Bishnoi and Davinder Parsad

49 Micropigmentation 451Gurvinder P. Thami

50 Camouflage in Vitiligo 459Chakravarthi R. Srinivas, Pradeep Balasubramanian, and C.K. Shashidharan Nair

51 Depigmentation Treatment for Vitiligo: Bleaching Cream, Laser, and Cryotherapy 469Nanja van Geel and Monique R.T.M. Thissen

52 Future Directions in the Treatment of Vitiligo 475Vishal Gupta and Somesh Gupta

53 Informed Consent 491Mats J. Olsson

Index 495

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About the Editors

Somesh Gupta, MD, DNB, MNAMS, Professor, Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India

Mats J. Olsson, MD, PhD, CEO, ParkCell AB and President, International Vitiligo Center, Uppsala, Sweden

Davinder Parsad, MD, Professor, Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

Henry W. Lim, MD, Chair Emeritus, Department of Dermatology and Senior Vice President for Academic Affairs, Henry Ford Health System. Past President, American Academy of Dermatology, Detroit, USA

Nanja van Geel, MD, PhD, Professor, Department of Dermatology, Ghent University Hospital, Ghent, Belgium

Amit G. Pandya, MD, Professor, Department of Dermatology, University of Texas, Southwestern Medical Center, Dallas, USA

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