Pharmaceutical Crystals. Science and Engineering

  • ID: 4459664
  • Book
  • 560 Pages
  • John Wiley and Sons Ltd
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An important resource that puts the focus on understanding and handling of organic crystals in drug development

Since a majority of pharmaceutical solid–state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal.

Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text:

  • Includes the most important aspects of solid–state organic chemistry and its role in drug development
  • Offers solutions for pharmaceutical form selection and crystallization processes
  • Contains a balance between the scientific fundamental and pharmaceutical applications
  • Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability

Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid–state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

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Chapter 1: Crystallography

Chapter 2: Nucleation

Chapter 3: Solid–State Characterization Techniques

Chapter 4: Intermolecular Interactions and Computational Modeling

Chapter 5: Polymorphism and Phase Transitions

Chapter 6: Measurement and Mathematical Relationships of Cocrystal Thermodynamic Properties

Chapter 7: Mechanical Properties

Chapter 8: Primary Processing of Organic Crystals

Chapter 9: Secondary Processing of Organic Crystals

Chapter 10: Chemical Stability and Reaction

Chapter 11: Crystalline Nanoparticles

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Tonglei Li is Professor in Industrial & Physical Pharmacy at Purdue University, West Lafayette, IN.

Alessandra Mattei is a Senior Scientist in Solid State Chemistry at AbbVie, North Chicago, IL.

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