Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students.
As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource.
- Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics
- Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology
- Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more
Part 1. The right versus moral duty to have a perfect genetic child 1. Predictive testing for neurodegenerative diseases 2. Predictive testing for common, multifactorial diseases 3. Whole genome sequencing as a method of prenatal genetic diagnosis 4. Prenatal testing for autosomal recessive disorders 5. Using crispr/cas 9 to select a perfect child 6. Prenatal testing without an objective medical reason 7. Expanded preconception carrier screening 8. Using genetic modifications for enhancement 9. Ethics of mitochondrial gene replacement therapy
Part 2. New issues arising within the geneticist
patient relationship 10. Revisiting the non-directive principle of genetic testing 11. Should incidental findings arising from prenatal tested be reported indiscriminately to patients?
Part 3. New issues generated by atypical family cores 12 Ethical issues raised by multi-parents 13. Ethical issues raised by same gender parents
Sorin Hostiuc, MD, PhD, is an Assistant Professor in the Department of Legal Medicine and Bioethics at Carol Davila Medicine and Pharmacy University, Bucharest, Romania, and Senior Physician at the National Institute of Legal Medicine Bucharest, Romania. Dr. Hostiuc has written extensively on such topics as informed consent, research ethics, history of medical ethics, and reproductive ethics, with over 100 published articles in PLOS ONE, Journal of Translational Medicine, and Frontiers in Neuroscience among other journals. He has also published three monographs in the Romanian language dealing with bioethical issues, including Ethics of Scientific Research, Ethics of Scientific Publishing, and Informed Consent, as well as a book chapter on the current state of bioethics in Bioethics - A Global Discourse (LIT Verlag Publishers, 2016). Dr. Hostiuc received his PhD in medicine and his MD, from Carol Davila Medicine and Pharmacy University. He also completed a certification in research ethics at the Icahn School of Medicine at Mount Sinai, New York, USA.