The Design and Synthesis of Antimalarial Agents

  • ID: 4482871
  • Book
  • 516 Pages
  • Elsevier Science and Technology
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The Design and Synthesis of Antimalarial Agents is a comprehensive, yet accessible, guide for those involved in the design, development and administration of antimalarial drugs. The book's aim is to support medicinal chemists in their search for improved and novel antimalarial drugs, providing practical guidance on current developments and highlighting promising leads. Beginning with a focus on the biological aspects of malaria, the book discusses the lifecycle of the parasite responsible for malaria, the problem of resistance, combinational therapy, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future.

In addition, it covers the medicinal chemistry of antimalarial agents in detail, with a focus on the design of antimalarial drugs supported by a review of the drug categories that have reached the market, as well as those in the pipeline. Finally, the synthesis of different classes of antimalarial agents is reviewed, including a discussion on chemical and process development.

  • Consolidates, for the first time, current developments in the discovery, design and synthesis of antimalarial drugs
  • Presents content in a style that is both thorough and engaging, supporting and encouraging students and researchers from interdisciplinary backgrounds
  • Highlights which drug targets are currently considered to be the most promising for future therapies and the classes of compounds being studied and perfected
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1. Historical overview of malaria and its treatment 2. Knowing one's enemy: Microbiology, genetics, life cycle and resistance mechanisms of the parasite 3. Drug targets and their rationale 4. Testing procedures 5. The cinchona alkaloids and the aminoquinolines 6. Artemisinin and artemisinin-related agents 7. Agents acting on pyrimidine metabolism (triazolopyrimidines) 8. Agents inhibiting haemoglobin hydrolysis (pyrimidine carbonitriles) 9. Antibiotics 10. Drugs targeting mitochondrial functions 11. Miscellaneous agents 12. Bio inorganic agents 13. Synthesis of aminoquinolines 14. Synthesis of artemisinin and related structures 15. Synthesis of other antimalarial agents

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Patrick, Graham L.
Dr. Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he was employed in the pharmaceutical industry as a research chemist and radiochemist working on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants.

His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of the West of Scotland in 1990 and has written a number of scientific books, which have an international reputation. An associate lecturer for the Open University with a particular interest in developing novel teaching techniques, Dr. Patrick is also a Member of the Royal Society of Chemistry, and a Fellow of the Higher Education Academy.

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