A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics

  • ID: 4482922
  • Book
  • 450 Pages
  • Elsevier Science and Technology
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A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.

  • Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy
  • Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials
  • Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward
  • Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies
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Part 1 Principles and concepts 1. History of stem cells 2. Stem cell features 3. Maintenance and culture of stem cells 4. Stem cell banks

Part 2 Promises and challenges of stem cell-based therapies 5. Osteoarthritis 6. Osteoporosis 7. Graft versus host disease 8. Systemic lupus erythematosus 9. Crohn's disease 10. Wound healing 11. Myocardial infarction 12. Parkinson syndrome 13. Alzheimer's disease 14. Spinal cord injuries

Part 3: Future perspectives 15. FDA regulations and navigating the pathway to approval 16. Stem cells as biological drug(s) 17. Stem cell-based therapeutic products 18. Use of stem cells in anti-aging strategies

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Chen, Xiao-Dong
Professor, Department of Comprehensive Dentistry, University of Texas Health Science Center, San Antonio, Chief, Regenerative Medicine Program, School of Dentistry, University of Texas Health Science Center, San Antonio, Founder and CSO, StemBioSys, Inc., San Antonio, TX, Visiting Professor, Shanghai Jiao-Tong University School of Medicine
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