Stem Cells and Biomaterials for Regenerative Medicine

  • ID: 4482932
  • Book
  • 500 Pages
  • Elsevier Science and Technology
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Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science-medicine, the latest technology, and clinical economics-the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more.

Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine.

  • Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language
  • Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more
  • Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials
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1. Introduction and historic perspective
2. Stem cells
definition and types of stem cells, stemness and differentiation
3. Modern methods of obtaining stem cells
overview of reprogramming methods
4. Transdifferentiation
direct way to obtain cell precursors for regenerative medicine
5. Generation of organs based on repopulation of cell-free extracellular matrix scaffolds
6. Introduction to transplantology
7. Biomaterials
8. Overview of technologies applied for biomaterial production
9. Quality control of biomaterials
10. Methods of biomaterial-aided cell delivery
11. Example of successful biomaterial-based artificial organ
artificial cornea
12. Example of successful biomaterial-based artificial organ
artificial hip
13. Example of successful biomaterial-based artificial organ
artificial skin
14. Biomatreials, and artificial tissues
risk assessment
15. Regenerative medicine in numbers
16. Regenerative medicine
further development
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Los, Marek J.
Marek Los studied medicine at Jagiellonian Univ., Krakow, Poland. He obtained his doctoral degree from Univ. Heidelberg, in 1995, and habilitation (academic teaching license) in Molecular Medicine, from Univ. Muenster in 2002. He is currently the head of Department of Molecular Biology, Faculty of Pharmacy, Silesian University of Medicine, in Katowice, Poland. He is also assoc. editor at The European Journal of Pharmacology, holds 2 Visiting Professorships at other Polish universities, and a 'Senior Scientific Adviser' position at Linkocare AB, Linköping, Sweden. Linkocare's core business is the production of artificial corneas. Dr. Los (co-)authors about 150 scientific papers, some of them highly-cited, edited several books and volumes. He has been serving as member of a number of editorial boards of scientific journals, as well as on various grant review committees in the Europe and in Canada. Dr. Los pursues various research projects within area of oncology, targeted cancer therapies and Regenerative Medicine. His most important scientific achievements were the description of involvement of caspase family of proteases in CD95 (APO-1/Fas) mediated apoptosis, (Los et al., 1995; Nature 375: 81-83), and the discovery of the role of kinase Akt both in the regulation of cell survival and cell death of cancer cells (Maddika et al., 2008, J. Cell Sci.; Maddika et al., 2009, Mol. Cell. Biol.). His research interest encompasses cancer immunology, cell death execution pathways, as well as cancer stem cell biology, epigenetic reprogramming (production of iPS-cells), as well as transdifferentiation technologies.
Hudecki, Andrzej
Wiechec, Emilia
Emilia Wiechec has received MSc degree in the field of biotechnology of microorganisms from the University of Silesia (Poland) and PhD in the area of cancer biology and genetics from the University of Aarhus (Denmark). She is currently an assistant professor at the Department of Clinical and Experimental Medicine, Linköping University, Sweden. Her research area spans both cancer and genes that regulate (cancer) cell stemness. She investigates pro-survival and apoptotic pathways triggered in cancer (stem) cells (CSCs) by anticancer drugs. Her research interest encompasses cancer genetics, cancer stem cell biology and anti-cancer treatment. She aims at development of new anti-cancer drugs, preferentially targeting CSCs.
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