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Microfluidics for Pharmaceutical Applications. From Nano/Micro Systems Fabrication to Controlled Drug Delivery. Micro and Nano Technologies

  • Book

  • October 2018
  • Elsevier Science and Technology
  • ID: 4482947

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening.

These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications.

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Table of Contents

Section I: Principle of microfluidics 1. Lab-on-a-Chip technology and microfluidics 2. Fluid properties and hydrodynamics of microfluidic systems 3. Diffusion and mixing in microfluidic device 4. Microfluidic production of multicomponent multiple emulsions

Section II: Microfluidics for drug delivery applications 5. Microfabrication and Microfluidic Devices for Drug Delivery 6. Lab-on-a-chip preparation routes for organic nanomaterials for drug delivery 7. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems 8. Microfluidic production of inorganic nanomaterials for biomedical applications 9. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled release 10. Microfluidic technologies for local drug delivery 11. Droplet-based microfluidics for cell encapsulation and delivery 12. Antibody discovery using microfluidic systems 13. Single-cell screening using microfluidic systems

Section III: Microfluidics for analysis and drug delivery 14. Lab-on-a-chip techniques for high throughput proteomics and drug discovery 15. Microfluidics for chemical analysis and sample manipulation for pharmaceutical applications

Section IV: Future prospective and commercialization of microfluidic techniques 16. Future of microfluidics in research and in the market


Hélder A. Santos Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands. Hélder A. Santos is a Full Professor in Pharmaceutical Nanotechnology at the Faculty of Pharmacy of the University of Helsinki (Finland), Head of the Nanomedicines and Biomedical Engineering Lab, Director of the Doctoral Program in Drug Research, Director of FinPharmaNet in Finland, Chair of the Controlled Release Society Focus Group in Nanomedicine and Nanoscale Delivery, and Chairman and co-founder of Capsamedix Oy. Prof. Santos' research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics, and therapy. His research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work builds a bridge between engineering, pharmaceutical, and medical research. He is the author/co-author of more than 330 publications, including reviews, journal editorials, book chapters, 4 edited books, and more than 260 conference proceedings/abstracts. He also holds 4 patents in the field. Dongfei Liu Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. Dongfei Liu is a Postdoctoral Fellow and PI at the Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. He has developed a versatile and robust microfluidics platform to prepare extremely stable drug nanocrystals. Hongbo Zhang Assistant Professor, Åbo Akademi, Finland. Hongbo Zhang is an Assistant Professor at Åbo Akademi, Finland. His research focuses on nanostructured materials prepared by microfluidics for drug delivery applications.