Polyphenols in Prevention and Treatment of Human Disease, Second Edition authoritatively covers evidence of the powerful health benefits of polyphenols, touching on cardiovascular disease, cancer, obesity, diabetes and osteoporosis. This collection represents the contributions of an international group of experts in polyphenol research who share their expertise in endocrinology, public health, cardiology, pharmacology, agriculture and veterinary science. Researchers from diverse backgrounds will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted insights into the mechanisms of disease.
This reference fills a void in research where nutritionists and alternative therapies may be applicable.
- Describes polyphenol modulation of blood flow and oxygenation as a potential mechanism of protection against vascular atherosclerosis
- Describes how polyphenols and antioxidants frequently change immune defenses and actions
- Focuses on the most important areas of research and provides insights into their relationships and translational opportunities
CARDIAC HEALTH AND POLYPHENOLS 6. Pharmacology of Polyphenols in Cardiac Remodeling 7. Cacao Polyphenols Influence the Regulation of Apolipoproteins 8. Polyphenol Consumption and Blood Pressure 9. Cardiovascular Effects of Hesperidin 10. Wine Polyphenols in the Management of Cardiovascular Risk Factors 11. Cocoa, Flavonoids and Cardiovascular Protection 12. Emerging Applications of Metabolomics to Polyphenols and CVD Biomarker Discovery 13. Role of Gallic Acid in Cardiovascular Disorders 14. Cranberry Polyphenols: Effects on Cardiovascular Risk Factors 15. Polyphenols and Cardiometabolic Syndrome 16. Cocoa Polyphenols and Cardiovascular Health 17. The Use of Bergamot-Derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action 18. Fruit Polyphenols and Postprandial Inflammatory Stress
CANCER PREVENTION AND TREATMENT OF POLYPHENOLS 19. Modulation of Drug-Metabolizing Enzymes and Transporters by Polyphenols as an Anticarcinogenic Effect 20. Cancer Chemoprevention by Dietary Polyphenols: Role for Epigenetics and Inflammation 21. Polyphenol-Mediated In Vivo Cellular Responses during Carcinogenesis 22. Preventive Effects of Plant Polyphenols in the Promotion of Mammary Cancer and Testicular Damage Induced by Alcohol Drinking 23. Antioxidant and Pro-Oxidant Activities of Green Tea Polyphenols in Cancer Prevention 24. Polyphenols in Prostate Cancer 25. Modifying Effects of Polyphenols on Acute Colitis and Inflammation-Associated Colon Carcinogenesis 26. Bioavailability of Soy-Derived Isoflavones and Human Breast Cancer 27. Biological Activity of Resveratrol on an Ovarian Cancer Cell 28. Resveratrol Inhibitory Effects against a Malignant Tumor 29. Inhibition of Iron Absorption by Polyphenols as an Anticancer Mechanism 30. Plant Polyphenols as Chemopreventive Agents 31. Cancer Preventive Effects of Green Tea Polyphenols 32. Cancer Chemoprevention by Resveratrol Treatment 33. Polyphenols and Breast Cancer Prevention 34. Most Relevant Polyphenols Present in the Mediterranean Diet and Their Incidence in Cancer Diseases 35. BRAF Mutation in Melanoma and Dietary Polyphenols as Adjunctive Treatment Strategy 36. Radioprotective Effects of the Ocimum Flavonoids Orientin and Vicenin 37. Apple Polyphenols in Cancer Prevention 38. DNA Methylation as a Target of Cancer Chemoprevention by Dietary Polyphenols Punica granatum (Pomegranate Fruit)
Ronald Ross Watson PhD is a professor of Health Promotion Sciences in the University of Arizona Mel and Enid Zuckerman College of Public Health. He was one of the founding members of this school serving the mountain west of the USA. He is a professor of Family and Community Medicine in the School of Medicine at the University of Arizona. He began his research in public health at the Harvard School of Public Health as a fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia, and USA which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring at a Lt. Colonel. He published 450 papers, and presently directs or has directed several NIH funded biomedical grants relating to alcohol and disease particularly immune function and cardiovascular effects including studying complementary and alternative medicines. Professor Ronald Ross Watson was Director of a National Institutes of Health funded Alcohol Research Center for 5 years. The main goal of the Center was to understand the role of ethanol-induced immunosuppression on immune function and disease resistance in animals. He is an internationally recognized alcohol-researcher, nutritionist and immunologist. He also initiated and directed other NIH-associated work at The University of Arizona, College of Medicine. Dr. Watson has funding from companies and non-profit foundations to study bioactive foods' components in health promotion. Professor Watson attended the University of Idaho, but graduated from Brigham Young University in Provo, Utah, with a degree in Chemistry in 1966. He completed his Ph.D. degree in 1971 in Biochemistry from Michigan State University. His postdoctoral schooling was completed at the Harvard School of Public Health in Nutrition and Microbiology, including a two-year postdoctoral research experience in immunology. Professor Watson is a distinguished member of several national and international nutrition, immunology, and cancer societies. Overall his career has involved studying many foods for their uses in health promotion. He has edited 120 biomedical reference books, particularly in health and 450 papers and chapters. His teaching and research in foods, nutrition and bacterial disease also prepare him to edit this book. He has 4 edited works on nutrition in aging. He has extensive experience working with natural products, alcohol, exercise, functional foods and dietary extracts for health benefits and safety issues, including getting 12 patents. Dr. Watson has done laboratory studies in mice on immune functions that decline with aging and the role of supplements in delaying this process as modified by alcohol and drugs of abuse.
Preedy, Victor R.
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine.
Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier).
Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry.
To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.
Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadi's research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.