Apoptosis and Beyond. The Many Ways Cells Die, 2 Volume Set

  • ID: 4486784
  • Book
  • 848 Pages
  • John Wiley and Sons Ltd
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These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death

This two–volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each.

Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d–dependent necrosis; and the role of phospholipase in cell death.

  • Covers all known processes that dying cells undergo
  • Provides extensive coverage of a topic not fully covered before
  • Offers chapters written by top researchers in the field
  • Provides activities that link and contrast processes to each other

Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

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List of Contributors ix

Volume I

1 General View of the Cytoplasmic and Nuclear Features of Apoptosis 1

Humberto De Vitto, Juan P. Valencia, and James A. Radosevich

2 Mitochondria in Focus: Targeting the Cell–Death Mechanism 13

Humberto De Vitto, Roberta Palorini, Giuseppina Votta, and Ferdinando Chiaradonna

3 Microbial Programmed Cell Death 49

Neal D. Hammer

4 Autophagy 71

Mollie K. Rojas, Juel Chowdhury, Khatja Batool, Zane Deliu, and Abdallah Oweidi

5 Cell Injury, Adaptation, and Necrosis 83

Sarah G. Fitzpatrick and Sara C. Gordon

6 Necroptosis 99

Ben A. Croker, James A. Rickard, Arshed Al–Obeidi, Akshay A. D Cruz, and Motti Gerlic

7 Ferroptosis 127

Ebru Esin Yoruker and Ugur Gezer

8 Anoikis Regulation: Complexities, Distinctions, and Cell Differentiation 143

Marco Beauséjour, Ariane Boutin, and Pierre H. Vachon

9 Corni cation 181

Leopold Eckhart

10 Excitotoxicity 197

Julie Alagha, Sulaiman Alshaar, and Zane Deliu

11 Molecular Mechanisms Regulating Wallerian Degeneration 205

Mohammad Tauseef and Madeeha Aqil

12 Pyronecrosis 225

Maryam Khalili and James A. Radosevich

13 Phenoptosis: Programmed Death of an Organism 237

M.V. Skulachev and V.P. Skulachev

14 Molecular Mechanisms Underlying Oxytosis 289

Amalia M. Dolga, Sina Oppermann, Maren Richter, Birgit Honrath, Sandra Neitemeier, Anja Jelinek, Goutham Ganjam, and Carsten Culmsee

15 Pyroptosis 317

Kate E. Lawlor, Stephanie Conos, and James E. Vince

16 Paraptosis 343

Maryam Khalili and James A. Radosevich

17 Hematopoiesis and Eryptosis 367

Mollie K. Rojas, Chintan C. Gandhi, and Lawrence E. Feldman

Volume II

18 Cyclophilin D–Dependent Necrosis 375

Jatin Mehta and Chandi Charan Mandal

19 Role of Phospholipases in Cell Death 395

Manikanda Raja, Juel Chowdhury, and James A. Radosevich

20 TRIAD (Transcriptional Repression–Induced Atypical Death) 411

Takuya Tamura and Hitoshi Okazawa

21 Alkylating–Agent Cytotoxicity Associated with O6–Methylguanine 427

Latha M. Malaiyandi, Lawrence A. Potempa, Nicholas Marschalk, Paiboon Jungsuwadee, and Kirk E. Dineley

22 Entosis 463

Jamuna Bai A. and Ravishankar Rai V.

23 Mitotic Catastrophe 475

Raquel De Souza, Lais Costa Ayub, and Kenneth Yip

24 NETosis and ETosis: Incompletely Understood Types of Granulocyte Death and their Proposed Adaptive Bene ts and Costs 511

Marko Radic

25 Parthanatos: Poly ADP Ribose Polymerase (PARP)–Mediated Cell Death 535

Amos Fatokun

26 Methuosis: Drinking to Death 559

Madeeha Aqil

27 Oncosis 567

Priya Weerasinghe, Sarathi Hallock, Robert Brown, and L. Maximilian Buja

28 Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo 583

J. Gilloteaux, J.M. Jamison, D. Arnold, and J.L. Summers

29 Programmed Death 1 (PD1)–Mediated T–Cell Apoptosis and Cancer Immunotherapy 695

Chandi Charan Mandal, Jatin Mehta, and Vijay K. Prajapati

Index 723

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James A. Radosevich is a Professor and Staff Research Scientist at the University of Illinois, Dental College and Cancer Center/VA, Chicago Health Care System. He is also an Affiliate Professor at Roosevelt University, College of Pharmacy, Department of Biopharmaceutical Sciences.

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