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Global Malignant Melanoma Drug Market, Dosage, Price & Clinical Pipeline Outlook 2024

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  • 470 Pages
  • April 2018
  • Region: Global
  • Kuick Research
  • ID: 4497343

The Global Melanoma Market is Anticipated to Expand in Value from US$ close to 5 Billion in 2016 to an Estimated US$ 14 Billion by 2024, Representing a Robust Compound Annual Growth Rate (CAGR) of 12%

“Global Malignant Melanoma Drug Market, Dosage, Price & Clinical Pipeline Outlook 2024” report highlights:

  • Global Malignant Melanoma Drug Market Overview
  • Dosage, Price & Patent Insight
  • Global Malignant Melanoma Drug Clinical Pipeline: 197 Drugs
  • Marketed Malignant Melanoma Drug Clinical Insight: 25 Drugs
  • Sales Analysis of Global Melanoma Therapeutics
  • Regional Analysis of the Melanoma Drug Market

Melanoma occurs due to mutations in the skin cells which ultimately lead to the formation of malignant tumors. These tumors commonly originate in the pigment-producing melanocytes in the basal layer of the epidermis. Being an advanced form of skin cancer, it is the cause of maximum number of skin cancer deaths. An insight into the prevalence of melanoma shows a rising trend amplified by the use of tanning beds and increased exposure of skin to ultraviolet rays in regions like the US, Europe & Australia which currently show much higher prevalence than the rest of the world.

Inspite of melanoma being a fatal form of skin cancer, its early detection makes it easily treatable. The melanoma market is flooded with traditional therapeutic approaches of chemotherapy, radiation therapy and surgery with many advanced therapies slowly entering the market. However, each of the traditional method have several limitations; thus leading to an increased need for better and efficient therapeutics.

Current market trends indicate that the malignant melanoma market is slowly shifting to advance and targeted therapeutic methods such as vaccine and immunotherapy. The recent FDA approvals of six biologics within six years has been a boost to the growth of malignant melanoma market with many key players investing heavily on the research and development of therapeutics that have shown promising therapeutic results in clinical studies of malignant melanoma.

The Targeted therapy segment of the malignant melanoma market is anticipated to be the most promising market of the future due to its high efficacy with minimum side effects. Further, sales analysis and future projections of existing therapeutics show exponential growth for the newly introduced biologics like Opdive and cotellic due to multifold increase in adoption rate, positive post marketing response and feedback from users.

The US currently leads the global malignant melanoma market due to large patient base, easy availability and affordability of the newly introduced biologics followed by Europe. Other regions such as Australia and New Zealand have also contributed significantly to the current market size. However, the increasing patient base in highly populated regions like China and India is estimated to shift the market size to these Asian regions by the year 2024.

Overall, the global melanoma market is anticipated to expand in value from US$ close to 5 Billion in 2016 to an estimated US$ 14 billion by 2024, representing a robust Compound Annual Growth Rate (CAGR) of 12%. The advancement in research and development of therapeutics, early entry and dominance of immunotherapeutics, strong investor base and a robust clinical pipeline ensures a bright future for the key players involved in the segment.

This report on the global malignant melanoma is based on an in-depth analysis of the current market trends, Opportunities and Other dynamics that may have a significant impact on the market. Special emphasis has been put on the collection and analysis of latest data that will influence the market in the present and the future. Further, analysis of sales data, patent expiry, Cost analysis of therapeutics and collaboration between industries has been used to devise an accurate and efficient projection regarding the future of malignant melanoma market which clearly indicates it to be a key market in the future of skin cancer therapy. 

Table of Contents

1. Malignant Melanoma - Common Cancer with High Mortality
1.1 Prologue to Malignant Melanoma
1.2 Risk Factors Associated with Melanoma
1.3 Overview of Melanoma Diagnosis & Therapy

2. Analysis Regarding the Global Prevalence of Melanoma
2.1 Prevalence in the US
2.2 Prevalence in Europe & Rest of the World

3. Melanoma Market Analysis by Diagnosis & Screening
3.1 Stages of melanoma Diagnosis & Treatment Options
3.2 Cost Analysis of Melanoma Screening

4. Malignant Melanoma Therapy & Cost Analysis by Stage
4.1 Stage 0
4.2 Stage I
4.3 Stage II Melanoma
4.4 Stage III Melanoma
4.5 Stage IV Melanoma
4.6 Recurrent Melanoma

5. Malignant Melanoma Management & Therapy - Cost Analysis by Treatment Modality
5.1 Surgery
5.2 Radiation Therapy
5.3 Chemotherapy
5.3.1 Decarbazine
5.3.2 Temozolomide
5.3.3 Taxol (Paclitaxel & Carboplatin)
5.4 Biological Therapy/Targeted Therapies
5.4.1 T-VEC (Imlygic®)
5.4.2 Nivolumab (Opdivo®)
5.4.3 Ipilimumab (Yervoy®)
5.4.4 Pembrolizumab (Keytruda®)
5.4.5 Peginterferon alpha 2-b (Sylatron®)
5.4.6 Interleukin-2 (IL-2; Proleukin®)
5.5 Inhibitors in Malignant Melanoma Treatment
5.5.1 Vemurafenib (Zelboraf®) + Cobimetinib (Cotellic®)
5.5.2 Dabrafenib (Tafinlar®) + Trametinib (Mekinist®)
5.5.3 Vemurafenib (Zelboraf®)

6. Sales Analysis of Global Melanoma Therapeutics
6.1 Global- Melanoma Chemotherapy Drug Sales
6.2 Melanoma Targeted Therapy Sales Analysis

7. Malignant Melanoma Therapy – Market Trend & Scope Analysis
7.1 Overview - Screening & Traditional Therapy Market
7.2 Modern Melanoma Therapeutics Market

8. Global Malignant Melanoma Drug Clinical Pipeline Overview

9. Regional Analysis of the Melanoma Drug Market
9.1 North America
9.1.1 US
9.1.2 Canada
9.2 Europe
9.3 Asia Pacific
9.3.1 Japan
9.3.2 China
9.3.3 Australia
9.4 Middle East & Africa (MEA)

10. Global Melanoma Drug Market Dynamics
10.1 Driving Factors of the Malignant Melanoma Drug Market
10.2 Restraining Factors of the Melanoma Drug Market

11. Future Forecast Regarding the Malignant Melanoma Drug Market

12. Global Malignant Melanoma Drug Clinical Pipeline by Company & Phase
12.1 Unknown
12.2 Research
12.3 Preclinical
12.4 Clinical
12.5 Phase-I
12.6 Phase-I/II
12.7 Phase-II
12.8 Phase-II/III
12.9 Phase-III
12.10 Preregistration
12.11 Registered

13. Marketed Malignant Melanoma Drug Clinical Insight

14. Competitive Analysis
14.1 AVAX Technologies
14.2 Biogen Idec
14.3 BioVex
14.4 Bristol-Myers Squibb
14.5 Chiron
14.6 Enzon Pharmaceuticals
14.7 GlaxoSmithKline
14.8 Lorus Therapeutics
14.9 Medarex
14.10 Merck
14.11 Ono Pharmaceutical
14.12 Plexxikon
14.13 Reliance Life Sciences
14.14 Roche

List of Figures
Figure 1-1: Historical Timeline of Melanoma
Figure 1-2: Malignant Melanoma - Risk Factors
Figure 1-3: Difference between Normal Skin Lesions & Melanoma
Figure 1-4: Melanoma Development in Action
Figure 1-5: Melanoma- Biopsy Types
Figure 1-6: Biopsy Techniques used for the Diagnosis of melanoma
Figure 2-1: US - Melanoma Prevalence by Gender (Number of patients), 2018
Figure 2-2: 5 Year Survival Rate- by Stage of Therapy (%)
Figure 2-3: Europe - Regional Mortality by Melanoma (number of Deaths per 100,000 patients), 2012-2016
Figure 2-4: Global- Melanoma Prevalence (per 100,000 Individuals), 2016
Figure 3-1: Cost Analysis - Melanoma Screening Cost (US$), 2018
Figure 3-2: Australia - Melanoma Management & Therapy Cost Analysis (US$/Patient), 2018
Figure 4-1: Comparative Price Analysis- by Body Part affected by Melanoma, 2018
Figure 4-2: -Melanoma Stage 0 – Estimated Treatment Cost (US$), 2018
Figure 4-3: Stage I - Estimated Treatment Cost (US$), 2018
Figure 4-4: Melanoma Treatment Efficacy (Stage II) by Treatment Modality (%), 2018
Figure 4-5: Stage II -Estimated Cost Analysis by Technique (US$), 2018
Figure 4-6: Stage III/IV Treatment Modality Approach
Figure 5-1: Surgery-Average Cost Analysis Range by Stage (US$/Patient), 2018
Figure 5-2: Surgery - Average Cost Analysis (US$), 2016
Figure 5-3: Radiation Therapy - Average Cost Analysis by Melanoma Location (US$), 2018
Figure 5-4: Dosage Analysis - Decarbazine & Temozolomide(mg/kg)
Figure 5-5: Price Analysis - Decarbazine & Temozolomide(US$/100mg), 2018
Figure 5-6: Temozolomide - Price Analysis (US$), 2018
Figure 5-7: Temozolomide - Price Analysis (US$/mg), 2018
Figure 5-8: Cost Analysis - Melanoma Targeted Therapy (US$/Month), 2018
Figure 5-9: T-VEC: Mechanism of Action
Figure 5-10:T-VEC- Dosage Analysis(ml/ Plaque Forming Unit*)
Figure 5-11: Imlygic - Vial & Therapy Cost Analysis (US$), 2018
Figure 5-12: Nivolumab + Iplimumab-Dosage Analysis (mg)
Figure 5-13: Yervoy- Mechanism of Action in Melanoma Therapy
Figure 5-14: Nivolumab & Ipilimumab- Drug Price Analysis (US$/mg), 2018
Figure 5-15: Keytruda -Dosage Analysis (mg/kg)
Figure 5-16: Sylatron - Dosage Analysis (mcg/kg body weight/week)
Figure 5-17: Interleukin-2 Action Mechanism
Figure 5-18: Zelboraf & Cobimetinib - Dosage Analysis (mg)
Figure 5-19: Zelboraf & Cotellic – Price Analysis (US$/Month), 2018
Figure 5-20: Tafinlar- Dosage Analysis (mg Twice Daily)
Figure 5-21: Mekinist - Dosage Analysis (mg once daily)
Figure 6-1: Global - Melanoma Chemotherapeutics Sales (US$ Million), 2014-2016
Figure 6-2: Global - Melanoma Biological Therapeutics Sales (US$ Million), 2015-2016
Figure 7-1: Global - Melanoma Market Segmentation by Diagnosis & Therapy (%), 2018
Figure 7-2: Global- Melanoma Diagnosis Market Forecast (US$ Billion), 2016-2024
Figure 7-3: Global - Melanoma Chemotherapy Drug Sales Forecast (US$ Billion), 2018-2024
Figure 7-4: Global - Melanoma Surgery Market Forecast (US$ Million), 2018-2024
Figure 7-5: Global- Radiation Melanoma Therapy Forecast (US$ Million), 2018-2024
Figure 7-6: Global – Melanoma Targeted Therapy Market Forecast, 2016-2024
Figure 8-1: Global - Malignant Melanoma Pipeline by Phase (%), 2018 till 2024
Figure 8-2: Global - Malignant Melanoma Pipeline by Phase (Number), 2018 till 2024
Figure 8-3: Global - Malignant Melanoma Pipeline by Phase (%),2018 till 2024
Figure 8-4: Global - Malignant Melanoma Pipeline by Phase (Number), 2018 till 2024
Figure 9-1: US - Melanoma Therapeutics Market Forecast (US$ Billion), 2016-2024
Figure 9-2: Canada- Melanoma Therapeutics Market Forecast (US$ Million), 2016-2024
Figure 9-3: Europe - Treatment Modality Used in Melanoma Therapy, 2016-2017
Figure 10-1: Driving Factors of the Global Melanoma Drug Market
Figure 10-2: Melanoma Drug Market - Growth Restraining Factors

Table 3-1: Melanoma Stage, Description & Available Treatment Options




Companies Mentioned

A selection of companies mentioned in this report includes:

  • AVAX Technologies
  • Biogen Idec
  • BioVex
  • Bristol-Myers Squibb
  • Chiron
  • Enzon Pharmaceuticals
  • GlaxoSmithKline
  • Lorus Therapeutics
  • Medarex
  • Merck
  • Ono Pharmaceutical
  • Plexxikon
  • Reliance Life Sciences
  • Roche