Presented in three parts – Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes – it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.
GENERAL ASPECTS AND METHODOLOGY
Epigenetic inhibitors in cancer
Structural Biology of Epigenetic Targets
Mass Spectrometry approaches
Peptide Microarrays for epigenetic targets
Target fishing and chemoproteomics
Chemical probe development
EPIGENETIC TARGET CLASSES
Methyl–Lysine Reader Proteins
DNA modifying enzymes
Parasitic Epigenetic Targets