Epigenetic Targets in Drug Discovery. Methods and Principles in Medicinal Chemistry - Product Image

Epigenetic Targets in Drug Discovery. Methods and Principles in Medicinal Chemistry

  • ID: 4517484
  • Book
  • 416 Pages
  • John Wiley and Sons Ltd
1 of 4
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl–lysine reader proteins.

Presented in three parts – Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes – it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.

Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.
Note: Product cover images may vary from those shown
2 of 4
Introduction to Epigenetics

GENERAL ASPECTS AND METHODOLOGY

Epigenetic inhibitors in cancer

Structural Biology of Epigenetic Targets

Computer–based approaches

Mass Spectrometry approaches

Peptide Microarrays for epigenetic targets

Target fishing and chemoproteomics

Chemical probe development

EPIGENETIC TARGET CLASSES

HDAC inhibitors

Sirtuins

Methyltransferases

Demethylases LSD1

JMJD

Histone Acetyltransferases

BRD Bromodomains

Methyl–Lysine Reader Proteins

DNA modifying enzymes

Parasitic Epigenetic Targets
Note: Product cover images may vary from those shown
3 of 4

Loading
LOADING...

4 of 4
Wolfgang Sippl
Manfred Jung
Raimund Mannhold
Helmut Buschmann
Jörg Holenz
Note: Product cover images may vary from those shown
5 of 4
Note: Product cover images may vary from those shown
Adroll
adroll