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The Science of Hormesis in Health and Longevity

  • Book

  • October 2018
  • Elsevier Science and Technology
  • ID: 4519409

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

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Table of Contents

Section 1: HISTORY, TERMINOLOGY AND CHALLENGES 1. The dose-response revolution: how hormesis became significant Edward J. Calabrese 2. Mild stress-induced hormesis: hopes and challenges Eric Le Bourg 3. Primary stress response pathways for preconditioning and physiological hormesis Suresh Rattan and Sumangala Bhattacharya

Section 2: CLINICAL AND LIFESTYLE HORMESIS 4. Remote ischemic preconditioning as a form of hormesis Robert A. Kloner 5. Exercise hormesis for health and longevity Zsolt Radak 6. Nutritional hormesis in a modern environment Helen R. Griffiths 7. Phyto-Hormetins in a Clinical Setting Iris R. Bell 8. Intermittent fasting-dietary restriction as a biological hormetin for health benefits Gurcharan Kaur Sr. 9. Hormetic Responses to Ethanol Ingestion: Focus on Moderation and Cardiovascular Protection Ronald J. Korthuis 10. Thermal waters and the hormetic effects of hydrogen sulfide on inflammatory arthritis and wound healing Giovanni Scapagnini

Section 3: HOREMTIC STRESSORS 11. Hormesis through low dose radiation Alexander Vaiserman 12. Metabolic stress
signaling and metabolic adaptation Thorsten Heinzel 13. DNA damage-induced hormetic responses Christian Kosan and Zhao-Qi Wang 14. Pathogen-induced hormetic responses Reinhard Wetzker and Michael Bauer 15. Neuronal stress and its hormetic aspects Britta Qualmann 16. Energetic Stress and Proteodynamics in Aging and Longevity Karyn L. Hamilton 17. Repeated electromagnetic field stimulation in aging and health Felipe Pablo Perez

Section 4: HORMETIC INTERVENTIONS AND NOVEL PERSPECTIVES 18. Hormesis for healthy ageing Suresh Rattan 19. Enhancing sports performance through hormesis Dick Thijsse 20. Circadian regulation of hormesis for health and longevity Anita Jagota 21. A Roadmap for Cross Operationalisation of Resilience Shima Beigi 22. Mindfulness, health and longevity Jesper Dahlgaard, Mimi Yung Mehlsen, Malene Munk Jørgensen, Rikke Katrine Jentoft Olsen, Niels Gregersen, Anne Maj van der Velden and Antonia Sumbundu 23. Buteyko breathing and ketogenic diet as potential hormetins in non-pharmacological metabolic approaches to health and longevity Misha Sakharoff 24. Treating neurodegenerative diseases with low doses of ionizing radiation Jerry Milton Cuttler 25. Interactions with technology as a cognitive, 'healthy ageing' hormetic stimulus Marios Kyriazis


Suresh I. S. Rattan Head, Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark. Dr. Rattan is head of the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark. He is an internationally renowned biogerontologist with more than 30 years of experience in research, teaching, scientific writing and public communication. He is one of the pioneers for the testing and application of hormesis in ageing research and interventions. His research expertise include elucidating the molecular mechanisms of human cellular ageing, with respect to protein synthesis, modifications and turnover. He is the discoverer of the ageing-modulatory effects of kinetin and zeatin, which are now used in several skin care products. He has published more than 250 original research papers and reviews in international journals and books. He has extensive experience and success in compiling and editing/co-editing 15 books for various publishers. He is the founder and current Editor-in-Chief of the journal Biogerontology. He is also the author of popular science books for children in several languages, including English, Punjabi and Danish Marios Kyriazi Biological Gerontologist, British Longevity Society, ELPI Foundation for Indefinite Lifespans. Dr. Kyriazi is a medical doctor (MD) from the University of Rome, Italy, and after preclinical work in the USA, worked as a clinician in acute medicine in Cyprus, and the UK. He subsequently qualified as a Gerontologist with interest in the biology of ageing and became a Chartered Member of the academic organisation 'Royal Society of Biology' in the UK. He also has a post-graduate qualification in Geriatric Medicine from the Royal College of Physicians of London. Other appointments include Member of the Board of Trustees at the Mediterranean Graduate School of Applied Social Cognition, affiliate researcher at the Evolution, Complexity and Cognition Group, University of Brussels, and a Ronin Research Scholar. He co-organises the Cyprus Symposium on 'Pathways to Indefinite Lifespans'. He is a member of several editorial boards. He is also a Member of the International Committee, Journal of the Spanish Society of Anti-ageing Medicine (SEMAL), Board Member (Directors) of the European Society of Anti-Ageing Medicine (ESAAM), a Peer-review Board Member, Anti-Ageing Conference London, among others. He portfolio comprises over 1000 articles, papers and lectures in the field of healthy ageing. Currently, he works with the ELPIs Foundation for Indefinite Lifespans to study the elimination of age-related degeneration. The research is focused on transdisciplinary models and explores common principles between biology, complexity sciences, evolution, cybernetics, neurosciences, and techno-cultural elements.