The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.
- Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging
- Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions
- Offers a clear understanding of hormesis' underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more
Section 2: STRESSORS AND STRESS RESPONSES 5. Oxidative stress 6. Metabolic stress 7. Genotoxic stress 8. Inflammatory and pathogen stress 9. Neuronal stress 10. Food restriction and its mimetics 11. Intermittent fasting as a hormetin 12. Mental stress 13. Aging and decreased resistance to multiple stresses
Section 3: HORMETIC MODULATION OF AGEING 14. Biological basis of ageing and its modulation through hormesis 15. Nutritional hormesis in a modern environment 16. Exercise as a paradigm for hormesis for health and longevity 17. Injuries can prolong lifespan in Drosophila melanogaster males 18. Intellectually and socially complex environment on human resilience in ageing 19. Interactions with technology as a cognitive anti-ageing hormetic stimulus
Section 4: HORMESIS AGAINST DISEASES 20. Radiation hormesis in disease prevention and treatment 21. Reduced Ovarian Cancer Incidence in Women Exposed to Low Dose Ionizing Background Radiation 22. Mitochondrial challenges in Cardiorenal Syndrome 23. Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid 24. Adaptive preconditioning in neurological diseases
therapeutic insights from proteostatic perturbations 25. Protecting neurons against cellular stress in Parkinson disease 26. Phyto-hormetins in a clincal setting
Section 5: FUTURE OF HORMETICS 27. Hormetin products in cosmetics and food supplements 28. Hopes and challenges for hormesis
Dr. Rattan is head of the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark. He is an internationally renowned biogerontologist with more than 30 years of experience in research, teaching, scientific writing and public communication. He is one of the pioneers for the testing and application of hormesis in ageing research and interventions. His research expertise include elucidating the molecular mechanisms of human cellular ageing, with respect to protein synthesis, modifications and turnover. He is the discoverer of the ageing-modulatory effects of kinetin and zeatin, which are now used in several skin care products. He has published more than 250 original research papers and reviews in international journals and books. He has extensive experience and success in compiling and editing/co-editing 15 books for various publishers. He is the founder and current Editor-in-Chief of the journal Biogerontology. He is also the author of popular science books for children in several languages, including English, Punjabi and Danish
Dr. Kyriazi is a medical doctor (MD) from the University of Rome, Italy, and after preclinical work in the USA, worked as a clinician in acute medicine in Cyprus, and the UK. He subsequently qualified as a Gerontologist with interest in the biology of ageing and became a Chartered Member of the academic organisation 'Royal Society of Biology' in the UK. He also has a post-graduate qualification in Geriatric Medicine from the Royal College of Physicians of London. Other appointments include Member of the Board of Trustees at the Mediterranean Graduate School of Applied Social Cognition, affiliate researcher at the Evolution, Complexity and Cognition Group, University of Brussels, and a Ronin Research Scholar. He co-organises the Cyprus Symposium on 'Pathways to Indefinite Lifespans'. He is a member of several editorial boards. He is also a Member of the International Committee, Journal of the Spanish Society of Anti-ageing Medicine (SEMAL), Board Member (Directors) of the European Society of Anti-Ageing Medicine (ESAAM), a Peer-review Board Member, Anti-Ageing Conference London, among others. He portfolio comprises over 1000 articles, papers and lectures in the field of healthy ageing. Currently, he works with the ELPIs Foundation for Indefinite Lifespans to study the elimination of age-related degeneration. The research is focused on transdisciplinary models and explores common principles between biology, complexity sciences, evolution, cybernetics, neurosciences, and techno-cultural elements.