This issue of Hematology/Oncology Clinics, edited by Dr. Colin A. Sieff, will focus on Bone Marrow Failure. Topics include, but are not limited to, Acquired and Inherited Bone Marrow Failure; Kickapoo Joy Juice and Somatic Mutations in the Pathogenesis of AA; Somatic Mutations in Aplastic Anemia; Recent Advances and Long-term Results of Medical Treatment of AA; Upfront Matched Unrelated Donor Transplantation in AA; Significance of Clonal Mutations in the Diagnosis and Management of Myelodysplastic Syndrome; Alternate (Haploidental) Donor Transplantation in AA; Management of Diamond Blackfan Anemia and Prospects for Novel Treatment; MDS, AML and Cancer Surveillance in Fanconi Anemia; Diagnosis, Treatment and Molecular Pathology of Shwachman Diamond Syndrome; Clinical Implications of Clonal Hematopoiesis in Dyskeratosis congenita; and Germline GATA2 Mutations and Bone Marrow Failure.
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Preface: Acquired and Inherited Bone Marrow Failure Syndromes
Introduction to Acquired and Inherited Bone Marrow Failure
The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited
Somatic Mutations in Aplastic Anemia
Recent Advances and Long-Term Results of Medical Treatment of Acquired Aplastic Anemia: Are Patients Cured?
Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia
Haploidentical Donor Bone Marrow Transplantation for Severe Aplastic Anemia
Significance of Clonal Mutations in Bone Marrow Failure and Inherited Myelodysplastic Syndrome/Acute Myeloid Leukemia Predisposition Syndromes
Myelodysplastic Syndrome, Acute Myeloid Leukemia, and Cancer Surveillance in Fanconi Anemia
Evaluation and Management of Hematopoietic Failure in Dyskeratosis Congenita
Diagnosis, Treatment, and Molecular Pathology of Shwachman-Diamond Syndrome
Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment
Germline GATA2 Mutation and Bone Marrow Failure
Monosomy 7 in Pediatric Myelodysplastic Syndromes