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Chronic lymphocytic leukemia (CLL): Update Bulletin #2

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  • May 2024
  • Region: Global
  • FirstWord Publishing
  • ID: 4521367

This edition presents key opinion leader (KOL) views on recent developments in the chronic lymphocytic leukaemia (CLL) market. Topics covered include: full results from the Phase III study of AbbVie/Roche’s Venclexta/Venclyxto (venetoclax) in combination with Rituxan/MabThera (rituximab; Roche) presented at the ASH meeting in December 2017; the initiation of a Phase III study investigating BeiGene’s novel Bruton’s tyrosine kinase (BTK) inhibitor zanubrutinib (BGB-3111) in patients with relapsed/refractory CLL; Phase I/II results for Juno Therapeutics/Celgene’s JCAR014; and pilot trial results for an anti-CD19 CAR-T cell therapy in combination with Imbruvica (ibrutinib; Janssen Biotech/AbbVie) in patients with high-risk CLL.

Business Questions:
  • In light of the positive results for Venclexta/Rituxan in the MURANO study, do KOLs envisage any changes to the second-line treatment regimen for CLL?
  • Do KOLs think it will be possible to overcome the side effects associated with the use of Venclexta/Rituxan?
  • If Venclexta/Rituxan is approved for treating patients with relapsed/refractory CLL, how widespread will its use become and why?
  • Will zanubrutinib’s selectivity for BTK inhibition translate into a clinically meaningful benefit for patients with CLL?
  • What role will zanubrutinib play within the CLL setting, if approved, and how well will it compete with other BTK inhibitors?
  • Will the toxicity associated with the use of anti-CD19 CAR-T cells confine their role to one of salvage therapy for CLL?
  • Do KOLs think that combining anti-CD19 CAR-T cells with Imbruvica will provide any therapeutic advantages for patients with CLL?
  • Apart from CD19, are there any other molecules which can be identified by KOLs as potentially effective therapeutic targets for CAR-T cell therapy?