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Market Spotlight: Zika virus

  • ID: 4533469
  • Report
  • February 2020
  • Region: Global
  • 26 pages
  • Datamonitor Healthcare
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FEATURED COMPANIES

  • BioCryst
  • GeneOne
  • Imutex
  • Johnson & Johnson
  • Sanofi
  • Themis Bioscience
  • MORE
This Market Spotlight report covers the Zika virus market, comprising key pipeline therapies, clinical trials, probability of success, epidemiology, and licensing and acquisition deals.

Key Takeaways
  • The Zika virus was first reported in continental South America in Brazil in May 2015. In February 2016, between 440,000 and 1,300,000 people were infected in Brazil. In the US, about 225 Zika virus cases were reported in August 2017. In addition, 554 cases were reported in people infected through local mosquito-borne transmission. Furthermore, autochthonous Zika virus transmission was reported in 25 countries in the Americas, Africa, and Asia.
  • In 2016, it was estimated that there were between 508 and 1,778 imported cases in Europe, particularly in France, Portugal, and Italy.
  • The majority of industry-sponsored drugs in active clinical development for Zika virus are in Phase I, with just a single product in Phase II.
  • Therapies in development for Zika virus focus on the immune system, viral antigens, and RNA polymerase. Candidates comprise DNA vaccines such as the National Institutes of Health’s Zika Virus Vaccine, GeneOne’s GLS-5700, and Inovio’s INO-A002; Moderna’s mRNA vaccines; Themis Bioscience’s recombinant viral vector vaccine; Imutex’s AGS-v vaccine; hVIVO's AGS-v PLUS vaccine; Johnson & Johnson’s Ad26.ZIKV.001 vaccine; Takeda’s TAK-426 vaccine; Emergent BioSolutions’ ZIKV-IG; Valneva’s VLA 1601; and BioCryst’s galidesivir, a broad-spectrum antiviral drug.
  • The overall likelihood of approval of a Phase I antiviral asset is 14.3%, and the average probability a drug advances from Phase III is 74.4%. Drugs, on average, take 8.7 years from Phase I to approval, compared to 9.0 years in the overall infectious disease space.
  • There have been seven licensing and asset acquisition deals involving Zika virus drugs during 2015–20. The exclusive 2017 agreement between Emergent BioSolutions and Valneva, worth $58.3m, for the global rights to Valneva’s Zika vaccine technology and VLA 1601 was the largest deal.
  • All clinical trials for Zika virus have been in either Phase I or Phase II, with no Phase III trials to date.
  • The US leads in terms of the number of Zika virus clinical trials globally.
  • Inovio, GeneOne, and Emergent have two completed trials each in the Zika virus space.
  • Inovio leads industry sponsors with four clinical trials for Zika virus, followed by GeneOne and Sanofi.
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FEATURED COMPANIES

  • BioCryst
  • GeneOne
  • Imutex
  • Johnson & Johnson
  • Sanofi
  • Themis Bioscience
  • MORE
1. OVERVIEW

2. KEY TAKEAWAYS

3. DISEASE BACKGROUND

4. TREATMENT
  • Vaccines
  • Therapeutics
5. EPIDEMIOLOGY

6. PIPELINE DRUGS

7. KEY REGULATORY EVENTS
  • FDA Revokes Emergency Authorization On Ebola, Zika Tests
  • US FDA Greenlights First-In-Kind Diagnostics, Device
8. PROBABILITY OF SUCCESS

9. LICENSING AND ASSET ACQUISITION DEALS
  • GeoVax Collaborates With Enesi Pharma On Needle-Free Vaccines
10. CLINICAL TRIAL LANDSCAPE
  • Sponsors by status
  • Sponsors by phase
  • Recent events
11. BIBLIOGRAPHY

12. APPENDIX

LIST OF FIGURES
Figure 1: Recent epidemiological updates
Figure 2: Zika cases timeline
Figure 3: Overview of pipeline drugs for Zika virus in the US
Figure 4: Pipeline drugs for Zika virus, by company
Figure 5: Pipeline drugs for Zika virus, by drug type
Figure 6: Pipeline drugs for Zika virus, by classification
Figure 7: Probability of success in the Zika virus pipeline
Figure 8: Licensing and asset acquisition deals in Zika virus, 2015–20
Figure 9: Clinical trials in Zika virus
Figure 10: Top 10 drugs for clinical trials in Zika virus
Figure 11: Top 10 companies for clinical trials in Zika virus
Figure 12: Zika virus trial locations
Figure 13: Zika virus trials status
Figure 14: Zika virus trials sponsors, by phase

LIST OF TABLES
Table 1: Pipeline drugs for Zika virus in the US
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  • National Institutes of Health
  • GeneOne
  • Inovio
  • Moderna
  • Themis Bioscience
  • Imutex
  • hVIVO
  • Johnson & Johnson
  • Takeda
  • Emergent BioSolutions
  • Valneva
  • BioCryst
  • Sanofi
Note: Product cover images may vary from those shown
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