Oncogenomics

  • ID: 4539989
  • Book
  • 718 Pages
  • Elsevier Science and Technology
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Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies.

- Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies- Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types- Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

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Preface

PART I: MOLECULAR MEDICINE: A NOVEL APPROACH TO CANCER INVESTIGATION

1. FROM THE DOUBLE HELIX TO ONCOGENOMICS AND PRECISION CANCER MEDICINE: AN EVOLVING STORY Franco Dammacco and Franco Silvestris

2. INTRATUMOR HETEROGENEITY: BIOLOGICAL AND CLINICAL IMPLICATIONS Rekha Gyanchandani, Nolan Priedigkeit, Ahmed Basudan and Adrian V. Lee

3. THE ROLE OF PROTEOMICS IN CANCER RESEARCH Carolina Panis, Stephany Corre^a, Renata Binato and Eliana Abdelhay

4. NEXT-GENERATION SEQUENCING IN CLINICAL PRACTICE Umberto Malapelle, Pasquale Pisapia, Francesco Passiglia, Amélie Dendooven, Patrick Pauwels, Roberto Salgado and Christian Rolfo

5. CANCER EPIGENETICS: ABERRANT DNA METHYLATION IN CANCER DIAGNOSIS AND TREATMENT Hideyuki Takeshima, Harumi Yamada and Toshikazu Ushijima

6. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE Farhadul Islam, Vinod Gopalan and Alfred King-Yin Lam

7. CANCER STEM CELLS: ROLE IN TUMOR PROGRESSION AND TREATMENT RESISTANCE Ahmad R. Safa

8. TARGETING THE HEDGEHOG AND NOTCH SIGNALING PATHWAYS IN CANCER STEM CELLS Ankita Borah and D. Sakthi Kumar

9. CANCER STEM CELLS IN MULTIPLE MYELOMA AND THE DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES Franco Dammacco, Patrizia Leone, Franco Silvestris, Vito Racanelli and Angelo Vacca

PART II: ONCOGENOMICS: CIRCULATING BIOMARKERS IN CLINICAL ONCOLOGY

10. BONE METASTASES FROM SOLID TUMORS: IN SEARCH OF PREDICTIVE BIOMARKERS FOR CLINICAL TRANSLATION Franco Silvestris, Stella D'Oronzo, Domenica Lovero, Raffaele Palmirotta and Franco Dammacco

11. LIQUID BIOPSY AND GENOMIC ASSESSMENT FOR LUNG CANCER: THE ROLE IN CLINICAL PRACTICE? Véronique Hofman, Simon Heeke, Maryline Allègra, Marius Ilié and Paul Hofman

12. PROGNOSTIC AND PREDICTIVE ROLE OF CIRCULATING TUMOR CELLS Francesco Schettini, Mario Giuliano and Massimo Cristofanilli

13. CIRCULATING MIRNAS AS TUMOR BIOMARKERS Vikas Ghai, Inyoul Lee and Kai Wang

14. CIRCULATING DNA IN CANCER DIAGNOSIS AND PROGNOSIS Eveline E. Vietsch and Anton Wellstein

15. SEQUENCING A SINGLE CIRCULATING TUMOR CELL FOR GENOMIC ASSESSMENT Lei Xu, Nuria Coll Bastus and Yong-Jie Lu

16. SINGLE NUCLEOTIDE POLYMORPHISMS IN CANCER RESEARCH AND TREATMENT Massimo Di Maio

PART III: GASTROINTESTINAL TUMORS: MOLECULAR DIAGNOSIS AND TREATMENT

17. GASTRIC CANCERS: A MOLECULAR ROADMAP FOR PATIENT STRATIFICATION AND TARGETED THERAPIES Maxime Chénard-Poirier and Elizabeth C. Smyth

18. RESISTANCE TO EGFR TARGETING TREATMENTS IN COLORECTAL CANCER Michela Pucci and Mattia Lauriola

19. CIRCULATING DNA AND PROTEIN BIOMARKERS FOR THE TREATMENT OF TYROSINE KINASE INHIBITORS IN METASTATIC COLORECTAL CANCER Kjetil Søreide

20. RATIONALE FOR IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANCIES Vasiliki Michalarea and Elizabeth Smyth

21. PROTEOMICS PROFILING OF PANCREATIC CANCER: ROLES IN BIOMARKER DISCOVERY Hong Peng, Ru Chen and Sheng Pan

22. EMERGING TECHNOLOGIES FOR THE DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER Magdalena Swierczewska, Serguei Kozlov and Pavan P. Adiseshaiah

23. PERSONALIZED MEDICINE IN GASTROINTESTINAL STROMAL TUMORS Margherita Nannini and Guido Biasco

24. CIRCULATING MICRORNAS AS TUMOR BIOMARKERS IN HEPATOCELLULAR CARCINOMA Albrecht Piiper and Oliverwaidmann

PART IV: PERSPECTIVES IN BREAST CANCER GENOMICS

25. GENE PROFILES IN BREAST CANCER: TRANSLATION TO CLINICAL MEDICINE Serena Di Cosimo, Maria Grazia Daidone and Vera Cappelletti

26. NOVEL BIOMARKERS PREDICTING THE DEVELOPMENT OF BONE METASTASIS IN EARLY BREAST CANCER Michele Iuliani, Paolo Manca, Giulia Ribelli, Sonia Simonetti, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini

27. HER2-POSITIVE EARLY BREAST CANCER: AFFORDABLE RISKS, AFFORDABLE THERAPIES, AND NEW DEVELOPMENTS Pierfranco Conte, Mariavittoria Dieci, Graziavernaci and Valentina Guarneri

28. ROLE OF CIRCULATING TUMOR CELLS IN BREAST CANCER PATIENTS Rita Lampignano, A.M. Sofie Berghuis, Tanja Fehm and Hans Neubauer

29. OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER: MTOR INHIBITORS AND NEW DRUGS Paola Ferrari and Andrea Nicolini

30. EXPLORE GENOMIC PROFILES FOR TRIPLE-NEGATIVE BREAST CANCER TO DISCOVER DRUG TARGETS Xiaosheng Wang

46. BRAF-MUTANT MELANOMA: TREATMENT APPROACHES AND RESISTANCE MECHANISMS Svenja Meierjohann and Bastian Schilling
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Dammacco, Franco
Franco Dammacco is Emeritus Professor of Internal Medicine at the University of Bari Medical School and has been President of the Italian Society of Internal Medicine. His research and clinical interests include HCV-related cryoglobulinemic vasculitis, onco-hematology, connective tissue diseases and immunodeficiency syndromes. He is author or co-author of more than 470 papers and Editor-in-Chief of the journal Clinical and Experimental Medicine.
Silvestris, Franco
Franco Silvestris is Full Professor of Internal Medicine and Clinical Oncology, and Director of the Post-Graduation Residency Course in Medical Oncology at the University of Bari Medical School. Also, he is Coordinator of the Doctorate in 'Biomomecular Sciences in Pharmacology and Medicine' at the same University, and Director of the 'Oncogenomic Research Center' at the University-Hospital 'Policlinico', Bari. He is author or co-author of more than 180 scientific articles in clinical and molecular medicine.
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