Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs.
- Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition
- Analyzes the structure-activity relationships of inhibitors of each viral polymerase
- Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets
1. Viruses Containing Polymerases and Their Life Cycles 2. General and Common Features of Viral Polymerases 3. Substrate and Ligand Binding Specificity in Polymerases 4. Design and Development of Inhibitors of Different Viral Polymerases 5. Structure-Activity Relationship Studies on Inhibitors of Individual Viral Polymerase 6. In Silico Design of Inhibitors of Viral Polymerases 7. The Success and Failure of Antiviral Therapy based on Polymerases
Satya P. Gupta is presently a Professor Emeritus at Meerut Institute of Engineering and Technology (MIET), Meerut, India, after retiring as Professor in the Department of Applied Sciences at National Institute of Technical Teachers' Training and Research (NITTTR), Bhopal. Earlier he served Tata Institute of Fundamental Research (TIFR), Mumbai, a world renowned Institution of India, Birla Institute of Technology and Science (BITS), Pilani, and then (MIET) as its Director-cum Professor of Eminence in the Department of Pharmacy. Professor Gupta has a very long standing of teaching Quantum Chemistry, Pharmaceutical Chemistry, Biophysics, and Drug Design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, in 1967 and 1971, respectively. He is a world renowned scientist. For his work in Drug Design, he has bagged several honors and awards. To his credit, Gupta has more than 200 research publications in highly reputed national and international journals and several reviews in such highly prestigious periodicals as Chemical Reviews (American Chemical Society), Progress in Drug Research (Birkhäuser Verlag Basel, Switzerland), and Current Medicinal Chemistry (Bentham Science, Netherlands), and has been on editorial board of several international journals. Dr. Gupta himself has been editor of several scientific journals and books of international repute published by Springer Verlag, Heidelberg Germany; CRC Press, Taylor and Francis Group; Nova Science Publishers, NY, USA; and Elsevier (Academic Press), USA. He has delivered several lectures on Drug Design across the world. His scientific activity has brought him on the forefront of scientific community of the world.