Viral Polymerases. Structures, Functions and Roles as Antiviral Drug Targets

Table of Contents

1. RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy 2. Structure-Function Relationship of Negative-Stranded Viral RNA Polymerases: Prospectives for Antiviral Therapy 3. RNA-Dependent RNA Polymerase of Alphaviruses: A Potential Target for the Design of Drugs Against Alphaviruses 4. DNA-dependent DNA Polymerases as Drug Targets in Herpesviruses and Poxviruses 5. Polio Virus Polymerase: An Effective Target for Design and Development of Anti-polio Drugs 6. Studies on HIV-1 Polymerase and its Inhibitors 7. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics 8. Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase: An Integral Part of HCV Antiviral Therapy 9. HBV Polymerase as a Target for Development of Anti-HBV Drugs 10. Polymerases of Coronaviruses: Structure, Function and Inhibitors 11. Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors 12. Herpes Virus Polymerase Inhibitors 13.  Zika Virus Polymerase: Structure, Function and Inhibitors 14. Dengue Virus Polymerase: A Crucial Target for Anti-Viral Drug Discovery 15. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics

Authors

Satya Prakash Gupta Professor Emeritus, Department of Applied Sciences, National Institute of Technical Teachers' Training and Research, India Fellow, National Academy of Sciences, India. Satya P. Gupta is presently a Professor Emeritus at Meerut Institute of Engineering and Technology (MIET), Meerut, India, after retiring as Professor in the Department of Applied Sciences at National Institute of Technical Teachers' Training and Research (NITTTR), Bhopal. Earlier he served Tata Institute of Fundamental Research (TIFR), Mumbai, a world renowned Institution of India, Birla Institute of Technology and Science (BITS), Pilani, and then (MIET) as its Director-cum Professor of Eminence in the Department of Pharmacy. Professor Gupta has a very long standing of teaching Quantum Chemistry, Pharmaceutical Chemistry, Biophysics, and Drug Design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, in 1967 and 1971, respectively. He is a world renowned scientist. For his work in Drug Design, he has bagged several honors and awards. To his credit, Gupta has more than 200 research publications in highly reputed national and international journals and several reviews in such highly prestigious periodicals as Chemical Reviews (American Chemical Society), Progress in Drug Research (Birkhäuser Verlag Basel, Switzerland), and Current Medicinal Chemistry (Bentham Science, Netherlands), and has been on editorial board of several international journals. Dr. Gupta himself has been editor of several scientific journals and books of international repute published by Springer Verlag, Heidelberg Germany; CRC Press, Taylor and Francis Group; Nova Science Publishers, NY, USA; and Elsevier (Academic Press), USA. He has delivered several lectures on Drug Design across the world. His scientific activity has brought him on the forefront of scientific community of the world.