Modern Approaches in Drug Discovery, Vol 610. Methods in Enzymology

  • ID: 4540062
  • Book
  • 412 Pages
  • Elsevier Science and Technology
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Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Methods in Enzymology series
  • Updated release includes the latest information on the Intrinsically Disordered Proteins
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1. Introduction Charles Lesburg

Target Identification and Validation 2. Cell Painting/High Content Imaging Ron Davis 3. Target ID using chemical probes Paul E. Brennan 4. Mining the microbiome for targets Jia Huijue

Library Design 5. Data driven approaches for diversity and drug-likeness Andreas Bender

Screening 6. Affinity-based screening Christian Bergsdorf 7. Fragment screening (X-ray) Frank Von Delft 8. Array-based approaches Angela N. Koehler

Hit-to-lead: assessment and improvement of drug-like properties 9. Hit assessment and prioritization Michael E. Johnson

Lead Optimization: fine tuning and risk mitigation 10. Risk mitigation in drug discovery Michael A. Walters 11. Multivariable optimization, including unknown unknowns Matthew Segall 12. eCounterscreening Daniel McMasters

Emerging Methods 13. Advanced biophysical techniques including conformational sensing Joshua Salafsky
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