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Innovative Research in Life Sciences. Pathways to Scientific Impact, Public Health Improvement, and Economic Progress

  • ID: 4544354
  • Book
  • January 2019
  • 416 Pages
  • John Wiley and Sons Ltd
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I thoroughly enjoyed reading this book as it has taken me on a journey through time, across the globe and through multiple disciplines. Indeed, we need to be thinking about these concepts and applying them every day to do our jobs better.

Farah Magrabi, Macquarie University, Australia

The reader will find intriguing not only the title but also the content of the book.  I m also pleased that public health, and even more specifically epidemiology has an important place in this ambitious discussion.

Elena Andresen, Oregon Health & Science University, USA

This book is very well written and addresses an important topic.  It presents many reasons why basic scientists/researchers should establish collaborations and access information outside traditional means and not limit thinking but rather expand such and perhaps develop more innovative and translational research ventures that will advance science and not move it laterally.

Gerald Pepe, Eastern Virginia Medical School, USA

This book gathers logically and presents interestingly (with many examples) the qualities and attitudes a researcher must possess in order to become successful. On the long run, the deep and carefully reexamined research will be the one that lasts.

Zoltán Néda, Babe –Bolyai University, Romania 

I really liked the five pillars delineating the components of humanism in research.  This book has made a major contribution to the research ethics literature.

David Fleming, University of Missouri, USA

A comprehensive review of the research phase of life sciences from design to discovery with suggestions to improve innovation 

This vital resource explores the creative processes leading to biomedical innovation, identifies the obstacles and best practices of innovative laboratories, and supports the production of effective science. Innovative Research in Life Sciences draws on lessons from 400 award–winning scientists and research from leading universities. The book explores the innovative process in life sciences and puts the focus on how great ideas are born and become landmark scientific discoveries. The text provides a unique resource for developing professional competencies and applied skills of life sciences researchers.

The book examines what happens before the scientific paper is submitted for publication or the innovation becomes legally protected. This phase is the most neglected but most exciting in the process of scientific creativity and innovation. The author identifies twelve competencies of innovative biomedical researchers that described and analyzed. This important resource:

  • Highlights the research phase from design to discovery that precedes innovation disclosure
  • Offers a step by step explanation of how to improve innovation
  • Offers solutions for improving research and innovation productivity in the life sciences
  • Contains a variety of statistical databases and a vast number of stories about individual discoveries
  • Includes a process of published studies and national statistics of biomedical research and reviews the performance of research labs and academic institutions

Written for academics and researchers in biomedicine, pharmaceutical science, life sciences, drug discovery, pharmacology, Innovative Research in Life Sciences offers a guide to the creative processes leading to biomedical innovation and identifies the best practices of innovative scientists and laboratories.

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Preface 9

1. Pathways of the Research Innovator 13

Diverse outcomes of science 14

Best of both worlds: scientific and innovative 15

Seek research opportunities that are not just timely but also timeless. 16

Balancing research and innovation 17

Essential concepts of research innovation 19

Research innovation pathways to effects 20

Learning from award–winning scientists and serial innovators 22

Road to meaningful research disclosure 24

2. First Dimension: Scientific Impact 29

Intellectual impact and scientific pluralism 29

You can′t make a good landing out of a bad approach 31

Intellectual products of scientific endeavors 33

Reality means reproducability 37

One may not know in the beginning how the end will look like 38

3. Second dimension: Public health value 44

Improving health in mission statements of science 45

The road from basic research to better health 46

Breaking down silos: basic science and public health 48

Putting science to work and change lives 50

High–impact research driven by public health needs 51

4. Third dimension: Economic development 59

Economic impact of life sciences research 60

Blockbuster impact of university research 61

Good science must come first in commercialization 64

Without good science, there is no positive technology transfer 65

Impact of life sciences on the national economy 67

Diverse messages about economic impact at different levels 68

5. Slowdown and erosion 74

Signs of slowdown in research innovation 75

Obstacles to research innovation 76

Increasing costs of regulatory compliance 79

The gamble of science and shortermism′ 80

Sputnik moment: the need to accelerate research 82

6. Non–reproducible research 90

The boulder of non–reproducible research 91

Implications of non–reproducible results 92

Sources of non–repeatable research results 94

Rare but troubling: pathological science and fraudulent research 99

The way out: modeling, transparency and continuous quality improvement 101

7. Red tape and litigation 108

Bureaucratization of research 109

Regulatory burden on creativity 113

Protection of intellectual property 115

Conflicts over credit and case law of inventor recognition 116

Accountability for reproducibility 120

8. Humanism for Innovation 127

Research targeting by values of humanism 128

Identifying measures for performance improvement 130

Creativity needs diversity of people, cultures, and ideas 132

Rock solid values when the controversies mount 133

Counteracting flawed economic and social incentives 135

Focus and motivation for sacrificial effort 136

Numbers need stories and stories need numbers 137

9. Desire to understand first 142

We will surpass on the gray matter 142

Research talent needs scientific opportunity 144

Curiosity and research agenda 145

Be passionate without emotions 147

The power of logic and abstraction 148

Creativity and divergent thinking 150

Winning science: who gets the award? 151

Reading scientific papers is more difficult than writing them 152

10. Learning from the Best 158

The benefits of research mentoring 159

The mentored way to success 160

Mentoring minority students and researchers 162

Learn from leaders to become a leader 165

11. Cracking Public Health Needs 171

Epidemiology triggers basic research 172

Scientific assumptions meet the brutal truth of epidemics 174

Curiosity–driven research enlists epidemiology 175

The unparalleled value of retrospective studies 178

12. Engaged Research Science confronts the bubble bias 184

Resources and indispensable benefits of engaged research 185

Prolific partnerships of arguers 188

Talking through to achieve understanding 189

Academic engagement with the community 190

Corporate competence in life sciences 191

Team science and collaborative research 194

Bouncing ideas in the real world 195

13. Cross–cultural Convergence 200

International collaborations and mobility 201

Convergence of disciplines 203

Evolution of team science 206

If you have never been in minority, you have never said anything original 208

14. Targeting and Repurposing 213

Consequential research generates value to others 213

Targeting mechanisms goes beyond observation 215

Repurposing what is already known 216

Eureka moment of discovering the unexpected 218

From serendipity to practical applications 220

15. Trailblazing Technologies 225

Behind every great discovery, there is an elegant methodology 225

Sought after technique becomes the goal of research and development 228

The technical opportunity presents itself to the researcher 230

When the industrial designer decides to serve public health 232

16. Emulating Nature 238

Scanning nature for valuable compounds 238

Studying how nature solves the problem 241

Learning from the unexpected outlier 242

Intertwining ring of evidence 245

17. Scientific Modeling 250

Hallmarks of the scientific modeling 251

Scholarly intuition and triple evidence 255

Validation and refinement 256

Choosing models to understand how nature works 257

Understanding processes leads to practical solutions 260

18. Mastering Bioentrepreneurship 265

Catching the semi–truck: Researcher gets the first large grant 265

Commercialization of research products and byproducts 268

Outreach, elevator pitch and marketing 271

Planning for customer acquisition 274

Pipeline of life sciences innovation: assets to returns 276

19. Art of Scientific Communication 281

Yardstick of communication: original research report 282

Learning from examples and feedback 284

Evidence–based writing: sentences and paragraphs 286

Time honored structure of scientific manuscripts 288

Quality control: testing the manuscript before release 292

Publishing a research paper is not mission accomplished 294

20. Quality and performance improvement 300

Quality control looks at populations and organizations 301

Cycle of quality improvement in the research enterprise 304

Quality disposition of research projects 306

Measures of success in scientific research 306

21. Institutional and national strategies 313

Institutional opportunities to support research 313

Recruitment and retention of research faculty 317

Peer–comparisons of research productivity 319

Catapults of success: education of the youth 322

Evidence–based public policies for the knowledge society 323

22. International collaboration and competition 330

The flagship role of research universities 331

The next Silicon Valleys: what works and how it works 333

Scientific innovation and economic competition 336

International variation in research policies 337

Global networks to accelerate research 338

Innovative minds with a sense of social and global responsibility 339

List of scientists and serial innovators 344

List of concepts and terms 349

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E. Andrew Balas
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