Viral Vectors and Plasmid DNA Manufacturing Market (2nd Edition), 2018-2030

  • ID: 4564442
  • Report
  • Region: Global
  • 449 Pages
  • Roots Analysis
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Genetically modified therapies have emerged as a promising treatment option for various diseases (primarily ones that currently have no cure), including cancers, inherited disorders and certain viral infections. These therapies have demonstrated the potential to treat chronic indications, such as Alzheimer’s disease, Parkinson’s disease and rheumatoid arthritis, as well. Gene therapies, and other therapies that require genetic modification, involve the introduction of therapeutic DNA / gene of interest into a patient’s body / cells. This process is accomplished by the use of vectors. Over the last few decades, various viral and non-viral vectors have been developed, optimized and standardized for this purpose. Currently, the most popular viral vectors, on the basis of their use in active clinical trials, are those based on AAV, adenovirus, lentivirus and retrovirus. On the other hand, among non-viral gene delivery tools, plasmid DNA has emerged as the preferred option. Plasmid DNA is also used in the development and production of viral vectors and DNA vaccines. Recent advances have led to the emergence of several other innovative viral / non-viral gene delivery approaches that are being utilized for development of various therapies that require gene modification.

Overall, eleven genetically modified therapies have been approved so far; these are (in the order of approval, most recent first) LUXTURNA™, YESCARTA™, Kymriah™, INVOSSA™, Zalmoxis®, Strimvelis™, Imlygic®, Neovasculagen®, Rexin-G®, Oncorine® and Gendicine®. Amongst these, YESCARTA™ and Kymriah™ are T-cell based gene therapies that were recently approved by the FDA, in October 2017 and August 2017, respectively. In addition, over 430 gene therapy candidates are presently in different stages of clinical development, for which over 500 clinical studies are currently underway in various regions across the globe.  The growing number of gene therapy candidates, coupled with their rapid progression through various phases of clinical development, is expected to continue to create an increasing demand for vectors.

The “Viral Vectors and Plasmid DNA Manufacturing Market (2nd Edition), 2018-2030” report offers a comprehensive study of the current scenario of manufacturing of viral and non-viral vectors that are primarily used for the development of gene therapies and T-cell therapies. The study features an in-depth analysis, highlighting the capabilities of a diverse set of players, covering both contract manufacturers and companies with in-house capabilities. In addition to other elements, the study includes:

  • An overview of the current status of the market with respect to the players involved in manufacturing viral vectors, non-viral vectors and other / novel vectors. It features information on the location of their manufacturing facilities, year of establishment, scale of production, type of vectors manufactured and purpose of production (fulfilling in-house requirement / contract service provider) and the type of organization (industry / non-industry).
  • Elaborate profiles of key players that are currently carrying out, or are planning to conduct, commercial scale production of viral vectors / plasmid DNA; each profile provides an overview of the organization, its financial performance (if available), information on its manufacturing facilities, vector manufacturing technology, recent investments, expansions and collaborations, and a comprehensive future outlook.
  • A discussion on the factors driving the market and the various challenges associated with the vector production process.
  • An estimate of the overall installed vector manufacturing capacity of industry players based on their reported capacities (wherever available) and additional data collated via both secondary and primary research. The analysis highlights the distribution of the global capacity by vector type (viral vector and plasmid DNA), scale of operation (clinical and commercial), regions (North America, EU, Asia Pacific and the rest of the world) and size of the organization (small-sized, mid-sized and large-sized organizations).
  • An analysis of the various factors that are likely to influence the pricing of vectors, featuring different models / approaches that may be adopted by manufacturers to decide the prices of proprietary vectors.
  • An in-depth analysis of the viral vector and plasmid DNA manufacturers, featuring three schematic representations; these include [A] a three dimensional grid analysis, representing the distribution of vector manufacturers (on the basis of the type of vector) across various scales of operation and purpose of production (in-house operations / contract manufacturing services), [B] a logo landscape of viral vector and plasmid DNA manufacturers based on the type (industry / non-industry) and the size of the industry player (small-sized, mid-sized and large companies), and [C] a schematic world map representation, highlighting the geographical locations of vector manufacturing hubs.
  • An analysis of the recent collaborations (signed since 2015) focused on manufacturing of vectors on the basis of year in which the agreement was signed, type of agreement, type of vector, and scale of operation (laboratory, clinical and commercial).
  • An overview of other viral / non-viral gene delivery approaches that are currently being researched for the development of therapies involving genetic modification.

One of the key objectives of this report was to evaluate the current opportunity and the future potential of the vector manufacturing market over the coming decade. Based on various parameters, such as the likely increase in the number of clinical studies, increase in the patient population, existing price variations among different vector types, and the anticipated success of commercial gene therapy products, we have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the period 2018-2030. In addition, we have provided the likely distribution of the market based on type of vectors (AAV vector, adenoviral vector, lentiviral vector, retroviral vector, plasmid DNA and others), applications (gene therapy and T-cell therapy), therapeutic area (oncology, inflammation & immunology, neurological, ophthalmology, muscular, metabolic disorder, cardiovascular disorder and others), scale of operation (clinical, commercial and both) and geography (North America, EU, Asia Pacific and rest of the world).

The research, analysis and insights presented in this report are backed by a deep understanding of key insights gathered from both secondary and primary research. For the purpose of the study, we invited over 150 stakeholders to participate in a survey to solicit their opinions on upcoming opportunities and challenges that must be considered for a more inclusive growth. Our opinions and insights presented in this study were influenced by discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with following stakeholders:

  • Joost van den Berg (Director, Amsterdam BioTherapeutics Unit)
  • Semyon Rubinchik (Scientific Director, ACGT)
  • Nicole Faust (Chief Scientific Officer, CEVEC Pharmaceuticals)
  • Olivier Boisteau, (President / Co-Founder, Clean Cells), Laurent Ciavatti (Business Development Manager, Clean Cells) and Xavier Leclerc (Head of Gene Therapy, Clean Cells)
  • Colin Lee Novick (Managing Director, CJ Partners)
  • Cedric Szpirer (Executive & Scientific Director, Delphi Genetics)
  • Nicolas Grandchamp (R&D Leader, GEG Tech)
  • Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital)
  • Alain Lamproye (President of Biopharma Business Unit, Novasep)
  • Astrid Brammer (Senior Manager Business Development, Richter-Helm)
  • Marco Schmeer (Project Manager, Plasmid Factory) and Tatjana Buchholz (Marketing Manager, Plasmid Factory)
  • Jeffrey Hung (Chief Commercial Officer, Vigene Biosciences)
  • Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing)

Example Highlights

1. During our research, we identified over 160 manufacturers that are actively involved in the production of viral vectors and plasmid DNA; of these, around 15 players claim to have the capabilities to manufacture both vector types. The current market landscape features a healthy mix of industry players and non-industry players. Amongst the industry players, over 50% are large or mid-sized firms (with more than 50 employees). Several established firms have been involved in the production of vectors over the past few decades. However, the growing demand for these products have spurred the establishment of many start-ups in the recent years, such as (in the order of year of establishment) ViralGEN, Brammer Bio, YPOSKESI, VIVEbiotech, Xpress Biologics, 4D Molecular Therapeutics, GEG Tech, Cell and Gene Therapy Catapult and Vigene Biosciences.

2. More than 60 non-industry players, including universities, research institutes and hospitals, are also currently involved in producing viral vectors or plasmid DNA for use in genetically modified therapies. Examples of such organizations include (in alphabetical order, no selection criteria) Baylor College of Medicine, Cornell University, Duke University, Emory University School of Medicine, Harvard Gene Therapy Initiative, Institute of Medical Science Research Hospital, Memorial Sloan Kettering Cancer Center, St. Jude Children's Research Hospital, Telethon Institute of Genetics and Medicine, University of Florida, University of Iowa Carver College of Medicine, University of Massachusetts Medical School, University of Michigan Medical Center, University of North Carolina, University of Pittsburgh, University of Pennsylvania and University of South Carolina School of Medicine. In fact, there are several industry initiatives that are either closely affiliated to or have spun-off from academia. 

3. As most genetically modified therapies (including T-cell based therapies) are currently under development, the demand for research and clinical grade vectors is more than that for commercial grade vectors. We observed that approximately 80% of the players in this area manufacture vectors at the laboratory and / or clinical scale. However, some firms (around 30, as per our research) have developed / are developing commercial scale capacity for the production of viral vectors or plasmid DNA. Prominent examples include (in alphabetical order, no selection criteria) Biovian, BioReliance / SAFC, Cell and Gene Therapy Catapult, Cobra Biologics, FinVector, FUJIFILM Diosynth Biotechnologies, Kaneka Eurogentec, Lonza, MassBiologics, MolMed, Novasep, Oxford BioMedica, Vigene Biosciences and WuXi AppTec.

4. More than 80% of the players in this domain offer contract manufacturing services for vectors. However, certain well-established players that are actively involved in the development of genetically modified therapies or have received marketing authorizations for such therapies have acquired the necessary capabilities to produce cGMP grade vectors in-house; examples include Amgen, Shenzhen Sibiono GeneTech and uniQure. It is also worth highlighting that there are several players that produce research / clinical / commercial grade vectors for both in-house and outsourced operations. Examples of such companies include (in alphabetical order, no selection criteria) 4D Molecular Therapeutics, ATVIO Biotech, Biomay, GEG Tech, ID Pharma, LakePharma, MolMed, Oxford Genetics, Okairos, VGXI and Vibalogics. 

5. Although, the first three gene therapy products (namely Gendicine®, Oncorine® and Rexin-G®) were approved in Asian countries, North America and the EU are presently considered to be vector manufacturing hubs due to the high volume of active clinical studies, requiring vectors, being conducted in these regions. Approximately 52% of the vector manufacturing facilities that we came across are located in North America; this is followed by the EU, where approximately 38% of the world’s vector manufacturing facilities are situated. Specifically, in the Asia Pacific region, the key players that offer vector manufacturing (at clinical / commercial scale) include Cellular Biomedicine Group, Gene Medicine Japan / Kobe Biomedical Accelerator, ID Pharma and Takara Bio.

6. The current installed global vector manufacturing capacity for viral vectors and plasmid DNA is estimated to be over 50 thousand litres. It is worth mentioning that the major share (70%) of the global vector manufacturing capacity belongs to companies that are manufacturing vectors at both clinical and commercial scales. Across the major global regions, 50% of the total installed vector manufacturing capacity is in the US. This can be attributed to the large number of small-sized and mid-sized companies that are presently situated in this region.

7. Owing to various challenges associated with vector manufacturing, innovative and advanced technology platforms have been developed to improve process outcomes and mitigate the challenges related to safety, stability, purification and scale up, associated with conventional methods of vector production. Examples of such platforms include (in alphabetical order, no selection criteria) CAP®-GT (CEVEC Pharmaceuticals), GMP-Source™ plasmid DNA (Aldevron), HyperGRO™ (Nature Technology Corporation), LentiVector® platform (Oxford BioMedica), NAV® technology (REGENXBIO), ORT® technology (Cobra Biologics) and Staby® technology (Delphi Genetics). Moreover, certain companies are also involved in the development of innovative viral / non-viral gene delivery approaches, featuring the use of alphavirus, Bifidobacterium longum, Listeria monocytogenes, minicircle DNA, myxoma virus, Sendai virus, self-complementary gene sequences and transposons (Sleeping Beauty). Companies involved in the manufacturing of these vectors include (in alphabetical order, no selection criteria) Aldevron, Biomay, ID Pharma and BioReliance / SAFC.

8. The field has also witnessed the establishment of several partnerships between drug developers, vector manufacturers and other industry stakeholders. Around 80 collaboration agreements were inked during the period 2015-Q1 2018; the maximum number of instances (31) were reported in 2016, followed by 22 partnerships that were established in 2017. Around 30% of the deals were related to the manufacturing of vectors across different scales of operation; this was followed by technology licensing agreements (~26%).

9. Driven by the rapidly evolving pipeline of genetically modified therapies (including T-cell based therapies) and the increasing adoption of advanced production technologies, the vector manufacturing market is likely to grow at an accelerated pace. Overall, we expect the market to grow at an annualized rate of over 20% over the next decade. Specific to vector types, lentiviral vectors, followed by retroviral vectors, currently capture the largest share of the market; this is because several T-cell based gene therapies that are currently being evaluated in clinical studies are utilizing these vector types. By 2030, the landscape is likely to evolve as other vector types gain prominence.

10. Oncological indications will drive the demand for vectors (over 80%) over the next decade. In the short-term, clinical products are expected to dominate the market as commercial scale activity gradually becomes mainstream; in fact, by 2030, we expect commercial products to cater to over 75% of the total demand for viral vectors and plasmid DNA.

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1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Chapter Overview
3.2. Viral and Non-Viral Methods of Gene Transfer
3.3. Viral Vectors for Genetically Modified Therapies
3.4. Type of Viral Vectors
3.4.1. Adeno-associated Viral Vectors
3.4.1.1. Overview
3.4.1.2. Design and Manufacturing
3.4.1.3. Advantages
3.4.1.4. Limitations
3.4.2. Adenoviral Vectors
3.4.2.1. Overview
3.4.2.2. Design and Manufacturing
3.4.2.3. Advantages
3.4.2.4. Limitations
3.4.3. Lentiviral Vectors
3.4.3.1. Overview
3.4.3.2. Design and Manufacturing
3.4.3.3. Advantages
3.4.3.4. Limitations
3.4.4. Retroviral Vectors
3.4.4.1. Overview
3.4.4.2. Design and Manufacturing
3.4.4.3. Advantages
3.4.4.4. Limitations
3.4.5. Other Viral Vectors
3.4.5.1. Alphavirus
3.4.5.2. Foamy Virus
3.4.5.3. Herpes Simplex Virus
3.4.5.4. Sendai Virus
3.4.5.5. Simian Virus
3.4.5.6. Vaccinia Virus
3.5. Types of Non-Viral Vectors
3.5.1. Plasmid DNA
3.5.2. Liposomes, Lipoplexes and Polyplexes
3.5.3. Oligonucleotides
3.5.4. Other Non-Viral Vectors
3.5.5. Methods of Gene Delivery using Non-Viral Vectors: Methods of Transfection
3.5.5.1. Biolistic Methods
3.5.5.2. Electroporation
3.5.5.3. Receptor Mediated Gene Delivery
3.5.5.4. Gene Activated Matrix (GAM)
3.6.Applications of Viral and Non-Viral Vectors
3.6.1. Type of Therapy
3.6.1.1. Gene Therapy
3.6.1.2. Vaccinology
3.6.2. Current Trends in Vector Development / Manufacturing
3.6.2.1. Vector Engineering: Synthetic and Next Generation Vectors
3.6.2.2. Cargo Engineering

4. VIRAL VECTOR MANUFACTURERS: COMPETITIVE LANDSCAPE
4.1. Chapter Overview
4.2. Viral Vectors Manufacturers: Overall Market Landscape
4.2.1. Distribution by Year of Establishment
4.2.2. Distribution by Location of Manufacturing Facility
4.2.3. Distribution by Type of Organization
4.2.4. Distribution by Purpose of Production
4.2.5. Distribution by Type of Vector
4.2.6. Distribution by Scale of Production

5. PLASMID DNA MANUFACTURERS: COMPETITIVE LANDSCAPE
5.1. Chapter Overview
5.2. Plasmid DNA Manufacturers: Overall Market Landscape
5.2.1. Distribution by Year of Establishment
5.2.2. Distribution by Location of Manufacturing Facility
5.2.3. Distribution by Type of Organization
5.2.4. Distribution by Purpose of Production
5.2.5. Distribution by Scale of Production

6. VIRAL VECTORS AND PLASMID DNA MANUFACTURING IN NORTH AMERICA
6.1. Chapter Overview
6.2. Aldevron
6.2.1. Company Overview
6.2.2. Manufacturing Facilities
6.2.3. Manufacturing Experience
6.2.4. Recent Developments
6.2.5. Future Outlook
6.3. BioReliance / SAFC Commercial (Merck KGaA)
6.3.1. Company Overview
6.3.2. Financial Performance
6.3.3. Vector Manufacturing Technology
6.3.4. Manufacturing Facilities
6.3.5. Recent Developments
6.3.6. Future Outlook
6.4. bluebird bio
6.4.1. Company Overview
6.4.2. Financial Performance
6.4.3. Manufacturing Facilities
6.4.4. Manufacturing Experience
6.4.5. Recent Developments
6.4.6. Future Outlook
6.5. Brammer Bio
6.5.1. Company Overview
6.5.2. Manufacturing Facilities
6.5.3. Manufacturing Experience
6.5.4. Recent Developments
6.5.5. Future Outlook
6.6. FUJIFILM Diosynth Biotechnologies
6.6.1. Company Overview
6.6.2. Financial Information
6.6.3. Manufacturing Facilities
6.6.4. Manufacturing Experience
6.6.5. Future Outlook
6.7. MassBiologics
6.7.1. Company Overview
6.7.2. Manufacturing Facilities
6.7.3. Recent Developments
6.7.4. Future Outlook
6.8. Novasep
6.8.1. Company Overview
6.8.2. Financial Performance
6.8.3. Manufacturing Facilities
6.8.4. Manufacturing Experience
6.8.5. Recent Developments
6.8.6. Future Outlook
6.9. Spark Therapeutics
6.9.1. Company Overview
6.9.2. Financial Performance
6.9.3. Manufacturing Facility
6.9.4. Viral Vector Manufacturing Technology
6.9.5. Manufacturing Experience
6.9.6. Recent Developments
6.9.7. Future Outlook
6.10. Vigene Biosciences
6.10.1. Company Overview
6.10.2. Manufacturing Facility
6.10.3. Vector Manufacturing Technology
6.10.4. Manufacturing Experience
6.10.5. Recent Developments
6.10.6. Future Outlook

7. VIRAL VECTORS AND PLASMID DNA MANUFACTURING IN EUROPE
7.1. Chapter Overview
7.2. Biovian
7.2.1. Company Overview
7.2.2. Manufacturing Facility
7.2.3. Recent Developments
7.2.4. Future Outlook
7.3. Cell and Gene Therapy Catapult
7.3.1. Company Overview
7.3.2. Manufacturing Facilities
7.3.3. Recent Developments
7.3.4. Future Outlook
7.4. Cobra Biologics
7.4.1. Company Overview
7.4.2. Financial Performance
7.4.3. Manufacturing Facility
7.4.4. Vector Manufacturing Technology
7.4.5. Manufacturing Experience
7.4.6. Recent Developments
7.4.7. Future Outlook
7.5. FinVector
7.5.1. Company Overview
7.5.2. Manufacturing Facility
7.5.3. Viral Vector Manufacturing Technology
7.5.4. Manufacturing Experience
7.5.5. Future Outlook
7.6. Kaneka Eurogentec
7.6.1. Company Overview
7.6.2. Manufacturing Facility
7.6.3. Manufacturing Experience
7.6.4. Recent Developments
7.6.5. Future Outlook
7.7. Lonza
7.7.1. Company Overview
7.7.2. Financial Performance
7.7.3. Vector Manufacturing Technology
7.7.4. Manufacturing Facilities
7.7.5. Recent Developments
7.7.6. Future Outlook
7.8. MolMed
7.8.1. Company Overview
7.8.2. Financial Performance
7.8.3. Manufacturing Facilities
7.8.4. Manufacturing Experience
7.8.5. Recent Developments
7.8.6. Future Outlook
7.9. Oxford BioMedica
7.9.1. Company Overview
7.9.2. Financial Performance
7.9.3. Manufacturing Facilities
7.9.4. Viral Vector Manufacturing Technology
7.9.5. Manufacturing Experience
7.9.6. Recent Developments
7.9.7. Future Outlook
7.10. Richter-Helm
7.10.1. Company Overview
7.10.2. Manufacturing Facilities
7.10.3. Recent Developments
7.10.4. Future Outlook
7.11. Sanofi (CEPiA, Sanofi Pasteur, Genzyme)
7.11.1. Company Overview
7.11.2. Financial Performance
7.11.3. Manufacturing Facilities
7.11.4. Manufacturing Experience
7.11.5. Recent Developments
7.11.6. Future Outlook
7.12. uniQure
7.12.1. Company Overview
7.12.2. Financial Performance
7.12.3. Manufacturing Facilities
7.12.4. Viral Vectors Manufacturing Technology
7.12.5. Recent Developments
7.12.6. Future Outlook
7.13. VIVEbiotech
7.13.1. Company Overview
7.13.2. Vector Manufacturing Technology
7.13.3. Manufacturing Facilities
7.13.4. Recent Developments
7.13.5. Future Outlook

8. VIRAL VECTORS AND PLASMID DNA MANUFACTURING IN ASIA-PACIFIC
8.1. Chapter Overview
8.2. Wuxi AppTec
8.2.1. Company Overview
8.2.2. Financial Performance
8.2.3. Manufacturing Facilities
8.2.4. Manufacturing Experience
8.2.5. Recent Developments
8.2.6. Future Outlook
8.3. Other Key Players

9. EMERGING VECTORS
9.1. Chapter Overview
9.1.1. Alphavirus Based Vectors
9.1.2. Bifidobacterium longum (B. longum) Based Vectors
9.1.3. Cytomegalovirus (CMV) Based Vectors
9.1.4. Listeria Monocytogenes Based Vectors
9.1.5. Minicircle DNA Based Vectors
9.1.6. Myxoma Virus Based Vectors
9.1.7. Self-Complementary Vectors
9.1.8. Sendai Virus Based Vectors
9.1.9. Sleeping Beauty Transposons

10. RECENT COLLABORATIONS AND PARTNERSHIPS
10.1. Chapter Overview
10.2. Partnership Models
10.3. Viral Vectors and Plasmid DNA Manufacturing: Recent Collaborations and Partnerships
10.3.1. Analysis by Year of Partnership
10.3.2. Analysis by Type of Partnership
10.3.3. Analysis by Type of Vector
10.3.4. Analysis by Scale of Operation
10.3.5. Analysis by Number of Partnerships: Most Active Players
10.3.6. Analysis by Regions
10.3.6.1. Most Active Players
10.3.6.2. Intercontinental and Intracontinental Agreements
10.4. Other Collaborations

11. KEY INSIGHTS
11.1. Chapter Overview
11.2. Viral Vectors and Plasmid DNA Manufacturers: Competitive Landscape by Vector Type, Scale of Operation and Purpose of Manufacturing
11.3. Viral Vectors and Plasmid DNA Manufacturers: Logo Landscape by Vector Type and Size of the Company
11.4. Viral Vectors and Plasmid DNA Manufacturers: Prominent Geographical Hubs by Type of Manufacturer
11.4.1. Contract Manufacturers
11.4.2. In-House Manufacturers
11.5. Viral Vectors and Plasmid DNA Manufacturers: Distribution by Location of Manufacturing Facility and Type of Vector
11.5.1. AAV Vector Manufacturers
11.5.2. Adenoviral Vector Manufactures
11.5.3. Lentiviral Vector Manufactures
11.5.4. Retroviral Vector Manufactures
11.5.5. Plasmid DNA Manufactures

12. VIRAL VECTORS AND PLASMID DNA: COST PRICE ANALYSIS
12.1. Chapter Overview
12.2. Viral Vectors and Plasmid DNA Based Therapies (Genetically Modified Therapies): Factors Contributing to Higher Price Tags
12.3. Viral Vectors and Plasmid DNA Prices
12.3.1. Based on Expert Opinions
12.3.2. Based on Manufacturing Cost
12.3.2.1. Based on Technology Used
12.3.2.2. Based on Scale of Manufacturing
12.3.2.3. Based on Client Type
12.3.3. Price Points on Different Types of Vectors
12.4. Concluding Remarks

13. CAPACITY ANALYSIS
13.1. Chapter Overview
13.2. Key Assumptions and Methodology
13.3. Viral Vectors Manufacturing: Installed Global Capacity
13.3.1. Distribution by Size of Manufacturers
13.3.2. Distribution by Scale of Operation
13.3.3. Distribution by Location of Manufacturing Facilities
13.3.4. Concluding Remarks
13.4. Plasmid DNA Manufacturing: Installed Global Capacity
13.4.1. Distribution by Size of Manufacturers
13.4.2. Distribution by Scale of Operation
13.4.3. Distribution by Location of Manufacturing Facilities
13.4.4. Concluding Remarks
13.5. Viral Vectors and Plasmid DNA Manufacturing: Overall Installed Global Capacity
13.5.1. Concluding Remarks

14. MARKET SIZING AND OPPORTUNITY ANALYSIS
14.1. Chapter Overview
14.2. Scope of the Forecast
14.3. Forecast Methodology
14.4. Input Tables and Key Assumptions
14.5. Overall Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030
14.5.1. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Vector Type (AAV, Adenoviral, Lentiviral, Retroviral, Plasmid DNA, Other Viral Vectors)
14.5.1.1. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Market Attractiveness by Vector Type (AAV, Adenoviral, Lentiviral, Retroviral, Plasmid DNA, Other Viral Vectors)
14.5.2. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.5.3. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.5.4. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Scale of Operation (Clinical / Commercial)
14.5.5. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6. Opportunity from Commercial Products
14.6.1. AAV Vectors
14.6.1.1. AAV Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.6.1.2. AAV Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.6.1.3. AAV Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6.2. Adenoviral Vectors
14.6.2.1. Adenoviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.6.2.2. Adenoviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.6.2.3. Adenoviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6.3. Lentiviral Vectors
14.6.3.1. Lentiviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.6.3.2. Lentiviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.6.3.3. Lentiviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6.4. Retroviral Vectors
14.6.4.1. Retroviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.6.4.2. Retroviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.6.4.3. Retroviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6.5. Plasmid DNA
14.6.5.1. Plasmid DNA Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.6.5.2. Plasmid DNA Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.6.5.3. Plasmid DNA Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6.6. Other Viral Vectors
14.7. Opportunity from Clinical Products
14.7.1. AAV Vectors
14.7.1.1. AAV Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.7.1.2. AAV Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III)
14.7.1.3. AAV Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.7.2. Adenoviral Vectors
14.7.2.1. Adenoviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.7.2.2. Adenoviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III)
14.7.2.3. Adenoviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.7.3. Lentiviral Vectors
14.7.3.1. Lentiviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.7.3.2. Lentiviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III)
14.7.3.3. Lentiviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.7.4. Retroviral Vectors
14.7.4.1. Retroviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.7.4.2. Retroviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III)
14.7.4.3. Retroviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.7.5. Plasmid DNA
14.7.5.1. Plasmid DNA Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.7.5.2. Plasmid DNA Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III)
14.7.5.3. Plasmid DNA Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.7.6. Other Viral Vectors

15. DRIVERS AND CHALLENGES
15.1. Chapter Overview
15.2. Viral Vectors and Plasmid DNA: Drivers and Challenges
15.2.1. AAV Vectors
15.2.2. Adenoviral Vectors
15.2.3. Lentiviral Vectors
15.2.4. Retroviral Vectors
15.2.5. Plasmid DNA
15.3. Additional Information

16. SURVEY ANALYSIS
16.1. Chapter Overview
16.2. Seniority Level of Respondents
16.3. Type of Vector
16.4. Scale of Production
16.5. Vector Stabilization Technology
16.6. In-house / Contract Operations

17. CONCLUSION
17.1. Increasing Efforts Related to Development of Advanced Therapy Candidates that Require Genetic Manipulation have Led to a Rise in the Demand for Vectors
17.2. Manufacturing Efforts in this Domain Feature the involvement of Several Industry Players and Academic Institutes; Many Startups have also been Established in the Recent Past
17.3. Given Regulatory Stringencies and Exorbitant Costs Associated with Developing In-House Facilities, Outsourcing Has Emerged as a Reliable Option for Vector Manufacturing
17.4. Manufacturers Have Established their Presence Across Different Regions; the US and EU have Emerged as Key Hubs
17.5. Several Efforts to Develop Innovative Technology Platforms are Underway, and are Expected to Drive the Production of Efficient, Safe and Stable Vectors
17.6. Novel Viral and Bacterial Strains are Being Investigated as Vectors for use in Genetically Modified Therapies / Vaccines
17.7. The Partnership Activity in this Domain is on the Rise as Companies Actively Collaborate to Develop Innovative Manufacturing Technology Platforms
17.8. Driven by a Rapidly Evolving Pipeline of Therapies, the Market is Anticipated to Grow at an Accelerated Pace over the Coming Decade

18. EXECUTIVE INSIGHTS
18. Executive Insights
18.1. Chapter Overview
18.2. Amsterdam BioTherapeutics Unit (AmBTU)
18.2.1. Overview of the Organization
18.2.2. Interview Transcript: Joost van den Berg, Director
18.3. ACGT
18.3.1. Overview of the Organization
18.3.2. Interview Transcript: Semyon Rubinchik, Scientific Director
18.4. CEVEC Pharmaceuticals
18.4.1. Overview of the Organization
18.4.2. Interview Transcript: Nicole Faust, Chief Executive Officer & Chief Scientific Officer
18.5. Clean Cells
18.5.1. Overview of the Organization
18.5.2. Interview Transcript: Laurent Ciavatti, Business Development Manager, Olivier Boisteau, President / Co-Founder and Xavier Leclerc, Head of Gene Therapy
18.6. CJ PARTNERS
18.6.1. Overview of the Organization
18.6.2. Interview Transcript: Interview Transcript, Colin Lee Novick, Managing Director
18.7. Delphi Genetics
18.7.1. Overview of the Organization
18.7.2. Interview Transcript: Cedric Szpirer, Executive & Scientific Director
18.8. GEG Tech
18.8.1. Overview of the Organization
18.8.2. Interview Transcript: Nicolas Grandchamp, R&D Leader
18.9. MGH Viral Vector Development Facility, Massachusetts General Hospital
18.9.1. Overview of the Organization
18.9.2. Interview Transcript: Bakhos A Tannous, Director
18.10. Novasep
18.10.1. Overview of the Organization
18.10.2. Interview Transcript: Alain Lamproye, President of Biopharma Business Unit
18.11. Richter-Helm
18.11.1. Overview of the Organization
18.11.2. Interview Transcript: Astrid Brammer, Senior Manager Business Development
18.12. Plasmid Factory
18.12.1. Overview of the Organization
18.12.2. Interview Transcript: Marco Schmeer, Project Manager and Tatjana Buchholz, Marketing Manager
18.13. Vigene Biosciences
18.13.1. Overview of the Organization
18.13.2. Interview Transcript: Jeffrey Hung, Chief Commercial Officer
18.14. Waisman Biomanufacturing
18.14.1. Overview of the Organization
18.14.2. Interview Transcript: Brian M Dattilo, Business Development Manager

List of Figures:
Figure 3.1 Gene Transfer: Viral and Non-Viral Methods
Figure 4.1 Viral Vectors Manufacturers: Cumulative Trend by Year of Establishment
Figure 4.2 Viral Vectors Manufacturers: Distribution by Location of Manufacturing Facilities
Figure 4.3 Viral Vectors Manufacturers: Distribution by Type of Organization
Figure 4.4 Viral Vectors Manufacturers: Distribution by Purpose of Production (In-house Production v/s Contract Manufacturing Services)
Figure 4.5 Viral Vectors Manufacturers: Distribution by Type of Viral Vectors
Figure 4.6 Viral Vectors Manufacturers: Distribution by Scale of Production
Figure 5.1 Plasmid DNA Manufacturers: Cumulative Trend by Founding Year
Figure 5.2 Plasmid DNA Manufacturers: Distribution by Location of Manufacturing Facilities
Figure 5.3 Plasmid DNA Manufacturers: Distribution by Type of Organization
Figure 5.4 Plasmid DNA Manufacturers: Distribution by In-house Production v/s Contract Manufacturing Services
Figure 5.5 Plasmid DNA Manufacturers: Distribution by Scale of Production
Figure 6.1 SAFC Commercial: Revenues, 2011- Q3 2015 (USD Million)
Figure 6.2 H.A.V.E.: AAV Vector Manufacturing Technology
Figure 6.3 bluebird bio: Revenues, 2011- Q1 2018 (USD Million)
Figure 6.4 bluebird bio Viral Vectors: Stages of Manufacturing Process
Figure 6.5 FUJIFILM Holdings: Revenues, FY 2012-9M 2017 (JPY Billion)
Figure 6.6 Novasep: Revenues, 2013-2017 (EUR Million)
Figure 6.7 Novasep: Viral Vector Manufacturing Process
Figure 6.8 Spark Therapeutics: Revenues, 2014-9M 2017 (USD Million)
Figure 7.1 Lonza: Revenues, 2012-2017 (CHF Million)
Figure 7.2 MolMed: Revenues, 2012-2018 (EUR Million)
Figure 7.3 Oxford BioMedica: Revenues, 2014-H1 2017 (GBP Million)
Figure 7.4 Sanofi: Revenues, 2012-9M 2017 (EUR Billion)
Figure 7.5 uniQure: Revenues, 2013- 2017 (USD Million)
Figure 8.1 WuXi AppTec: Revenues, 2011-Q3 2015 (USD Million)
Figure 10.1 Viral Vectors and Plasmid DNA Partnerships: Cumulative Year-wise Trend (2015–Q1 2018)
Figure 10.2 Viral Vectors and Plasmid DNA Partnerships: Distribution by Type
Figure 10.3 Viral Vectors and Plasmid DNA Partnerships: Distribution by Type of Vector
Figure 10.4 Viral Vectors and Plasmid DNA Partnerships: Distribution by Scale of Operation
Figure 10.5 Viral Vectors and Plasmid DNA Partnerships: Most Active Players
Figure 10.6 Viral Vectors and Plasmid DNA Partnerships: Regional Distribution and Most Active Players
Figure 10.7 Viral Vectors and Plasmid DNA Partnerships: Regional Distribution by Intercontinental and Intracontinental Agreements
Figure 11.1 Viral Vectors and Plasmid DNA Manufacturers: Competitive Landscape by Vector Type, Scale of Operation and Purpose of Manufacturing
Figure 11.2 Viral Vectors and Plasmid DNA Manufacturers: Logo Landscape by Vector Type and Size of the Company
Figure 11.3 Viral Vectors and Plasmid DNA Contract Manufacturers: Prominent Geographical Hubs
Figure 11.4 Viral Vectors and Plasmid DNA In-House Manufacturers: Prominent Geographical Hubs
Figure 11.5 AAV Vector Manufacturers: Distribution by Location of Manufacturing Facility
Figure 11.6 Adenoviral Vector Manufacturers: Distribution by Location of Manufacturing Facility
Figure 11.7 Lentiviral Vector Manufacturers: Distribution by Location of Manufacturing Facility
Figure 11.8 Retroviral Vector Manufacturers: Distribution by Location of Manufacturing Facility
Figure 11.9 Plasmid DNA Manufacturers: Distribution by Location of Manufacturing Facility
Figure 13.1 Viral Vectors Installed Manufacturing Capacity: Distribution by Size of Manufacturers (Sample Data Set)
Figure 13.2 Plasmid DNA Installed Manufacturing Capacity: Distribution by Size of Manufacturers (Sample Data Set)
Figure 13.3 Viral Vectors Installed Manufacturing Capacity: Distribution by Size of Manufacturer
Figure 13.4 Viral Vectors Installed Manufacturing Capacity: Distribution by Range of Installed Capacity
Figure 13.5 Viral Vectors Installed Manufacturing Capacity: Distribution by Scale of Operation
Figure 13.6 Viral Vectors Installed Manufacturing Capacity: Distribution by Location of Manufacturing Facility
Figure 13.7 Plasmid DNA Installed Manufacturing Capacity: Distribution by Size of Manufacturer
Figure 13.8 Plasmid DNA Installed Manufacturing Capacity: Distribution by Range of Installed Capacity
Figure 13.9 Plasmid DNA Installed Manufacturing Capacity: Distribution by Scale of Operation
Figure 13.10 Plasmid DNA Installed Manufacturing Capacity: Distribution by Location of Manufacturing Facility
Figure 13.11 Overall Viral Vectors and Plasmid DNA Installed Global Manufacturing Capacity: Distribution by Type of Vector
Figure 13.12 Overall Viral Vectors and Plasmid DNA Installed Global Manufacturing Capacity: Distribution by Location of Manufacturing Facility
Figure 14.1 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030 (USD Billion)
Figure 14.2 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Type of Vector (AAV, Adenoviral, Lentiviral, Retroviral, Plasmid DNA, Other Viral Vectors) (USD Million)
Figure 14.3 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Market Attractiveness Analysis by Vector Type (AAV, Adenoviral, Lentiviral, Retroviral, Plasmid DNA, Other Viral Vectors)
Figure 14.4 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.5 Viral Vectors and Plasmid DNA Manufacturing Market, 2020, 2025 and 2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Figure 14.6 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Scale of Operation (Clinical / Commercial) (USD Million)
Figure 14.7 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.8 AAV Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.9 AAV Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, cardiovascular Disorders, Others) (USD Million)
Figure 14.10 AAV Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.11 Adenoviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.12 Adenoviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Figure 14.13 Adenoviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.14 Lentiviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.15 Lentiviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Figure 14.16 Lentiviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.17 Retroviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.18 Retroviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Figure 14.19 Retroviral Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.20 Plasmid DNA Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.21 Plasmid DNA Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Figure 14.22 Plasmid DNA Vector Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.23 Other Viral Vectors Manufacturing Market for Commercial Products, 2018-2030 (USD Million)
Figure 14.24 AAV Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.25 AAV Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Figure 14.26 AAV Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.27 Adenoviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.28 Adenoviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Figure 14.29 Adenoviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.30 Lentiviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.31 Lentiviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Figure 14.32 Lentiviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.33 Retroviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.34 Retroviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Figure 14.35 Retroviral Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.36 Plasmid DNA Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Figure 14.37 Plasmid DNA Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Figure 14.38 Plasmid DNA Vector Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Figure 14.39 Other Viral Vectors Manufacturing Market for Clinical Products, 2018-2030 (USD Million)
Figure 15.1 AAV Vectors: Drivers and Challenges
Figure 15.2 Adenoviral Vectors: Drivers and Challenges
Figure 15.3 Lentiviral Vectors: Drivers and Challenges
Figure 15.4 Retroviral Vectors: Drivers and Challenges
Figure 15.5 Plasmid DNA: Drivers and Challenges
Figure 16.1 Survey Analysis: Distribution by Type of Organization
Figure 16.2 Survey Analysis: Distribution by Location of Organization
Figure 16.3 Survey Analysis: Distribution by Seniority Level of Respondents
Figure 16.4 Survey Analysis: Distribution by Type of Vector
Figure 16.5 Survey Analysis: Distribution by Scale of Production
Figure 16.6 Survey Analysis: Vector Stabilization Technology
Figure 16.7 Survey Analysis: Distribution by Purpose of Production (In-house Production v/s Contract Services)

List of Tables:
Table 3.1 Viral Vectors: Key Features
Table 4.1 Viral Vectors: List of Manufacturers
Table 4.2 Viral Vectors Manufacturers: Information on Type of Viral Vectors
Table 4.3 Viral Vectors Manufacturers: Information on Scale of Production
Table 5.1 Plasmid DNA: List of Manufacturers
Table 5.2 Plasmid DNA Manufacturers: Scale of Production
Table 6.1 Viral Vector and Plasmid DNA Production: List of Players Profiled
Table 6.2 Aldevron Plasmid DNA: QC Assays
Table 6.3 Novasep Viral Vectors: Manufacturing Experience
Table 7.1 Viral Vectors and Plasmid DNA Production: List of Players Profiled
Table 7.2 FinVector Manufacturing Suites: Features
Table 8.1 List of Key Players based in Asia Pacific
Table 10.1 Viral Vectors and Plasmid DNA: List of Partnerships
Table 10.2 Viral Vectors and Plasmid DNA Partnerships: Most Active Players
Table 10.3 Viral Vectors and Plasmid DNA: List of Other Partnerships
Table 12.1 Viral Vectors and Plasmid DNA Cost Price Analysis: Expert Opinions / Primary Research
Table 12.2 Viral Vectors and Plasmid DNA: Prices of Vectors
Table 13.1 Viral Vectors Manufacturing Installed Global Capacity: Average Capacity by Size of Manufacturers (Sample Data Set)
Table 13.2 Plasmid DNA Manufacturing Installed Global Capacity: Average Capacity by Size of Manufacturers (Sample Data Set)
Table 13.3 Viral Vectors Manufacturing Installed Global Capacity: Distribution by Size of Manufacturers
Table 13.4 Plasmid DNA Manufacturing Installed Global Capacity: Distribution by Size of Manufacturer
Table 14.1 Viral Vectors and Plasmid DNA: Active Clinical Studies
Table 14.2 Viral Vectors and Plasmid DNA: Distribution by Patients Enrolled in the Active Clinical Studies
Table 14.3 Viral Vectors and Plasmid DNA: Number of Active Clinical Trials, 2018-2030
Table 14.4 Viral Vectors and Plasmid DNA: Number of Patients in Active Clinical Trials, 2018-2030
Table 14.5 Viral Vectors and Plasmid DNA: Approved / Late-Stage Genetically Modified Therapies
Table 16.1 Survey Response: Overview of the Participating Companies / Organizations
Table 16.2 Survey Response: Seniority Level of Respondents
Table 16.3 Survey Response: Type of Vector
Table 16.4 Survey Response: Scale of Production
Table 16.5 Survey Response: Vector Stabilization Technology
Table 16.6 Survey Response: Purpose of Production (In-house Production v/s Contract Services)
Table 18.1 Amsterdam BioTherapeutics Unit (AmBTU): Key Highlights
Table 18.2 ACGT: Key Highlights
Table 18.3 CEVEC Pharmaceuticals: Key Highlights
Table 18.4 Clean Cells: Key Highlights
Table 18.5 CJ PARTNERS Key Highlights
Table 18.6 Delphi Genetics: Key Highlights
Table 18.7 GEG Tech: Key Highlights
Table 18.8 MGH Viral Vector Development Facility, Massachusetts General Hospital: Key Highlights
Table 18.9 PlasmidFactory: Key Highlights
Table 18.10 Waisman Biomanufacturing: Key Highlights
Table 19.1 Viral Vectors Manufacturers: Cumulative Trend by Year of Establishment
Table 19.2 Viral Vectors Manufacturers: Distribution by Location of Manufacturing Facilities
Table 19.3 Viral Vectors Manufacturers: Distribution by Type of Organization
Table 19.4 Viral Vectors Manufacturers: Distribution by Purpose of Production (In-house Production v/s Contract Manufacturing Services)
Table 19.5 Viral Vectors Manufacturers: Distribution by Types of Viral Vectors
Table 19.6 Viral Vectors Manufacturers: Distribution by Scale of Production
Table 19.7 Plasmid DNA Manufacturers: Cumulative Trend by Year of Establishment
Table 19.8 Plasmid DNA Manufacturers: Distribution by Location of Manufacturing Facilities
Table 19.9 Plasmid DNA Manufacturers: Distribution by Type of Organization
Table 19.10 Plasmid DNA Manufacturers: Distribution by In-house Production v/s Contract Manufacturing Services
Table 19.11 Plasmid DNA Manufacturers: Distribution by Scale of Production
Table 19.12 SAFC: Revenues, 2011-Q3 2015 (USD Million)
Table 19.13 bluebird bio: Revenues, 2011-Q1 2018 (USD Million)
Table 19.14 FUJIFILM Holdings: Revenues, 2012-9M 2017 (JPY Billion)
Table 19.15 Novasep: Revenues, 2013-2016 (EUR Million)
Table 19.16 Spark Therapeutics: Revenues, 2014-Q1 2018 (USD Million)
Table 19.17 Lonza: Revenues, 2011-H1 2017 (CHF Million)
Table 19.18 MolMed: Revenues, 2012-2018 (EUR Million)
Table 19.19 Oxford BioMedica: Revenues, 2014-2017 (GBP Million)
Table 19.20 Sanofi: Revenues, 2012-Q1 2018 (EUR Billion)
Table 19.21 uniQure: Revenues, 2013-9M 2017 (USD Million)
Table 19.22 Wuxi AppTec: Revenues, 2011-Q3 2015 (USD Million)
Table 19.23 Viral Vectors and Plasmid DNA Partnerships: Cumulative Year-wise Trend (2015-Q1 2018)
Table 19.24 Viral Vectors and Plasmid DNA Partnerships: Distribution by Type
Table 19.25 Viral Vectors and Plasmid DNA Partnerships: Distribution by Type of Vector
Table 19.26 Viral Vectors and Plasmid DNA Partnerships: Distribution by Scale of Operation
Table 19.27 Viral Vectors and Plasmid DNA Partnerships: Most Active Players
Table 19.28 Viral Vectors and Plasmid DNA Partnerships: Regional Distribution and Most Active Players
Table 19.29 Viral Vectors and Plasmid DNA Partnerships: Regional Distribution by Intercontinental and Intracontinental Agreements
Table 19.30 Viral Vectors Installed Manufacturing Capacity: Distribution by Size of Manufacturers (Sample Data Set)
Table 19.31 Plasmid DNA Installed Manufacturing Capacity: Distribution by Size of Manufacturers (Sample Data Set)
Table 19.32 Viral Vectors Installed Manufacturing Capacity: Distribution by Size of Manufacturer
Table 19.33 Viral Vectors Installed Manufacturing Capacity: Distribution by Range of Installed Capacity
Table 19.34 Viral Vectors Installed Manufacturing Capacity: Distribution by Scale of Operation
Table 19.35 Viral Vectors Installed Manufacturing Capacity: Distribution by Location of Manufacturing Facility
Table 19.36 Plasmid DNA Installed Manufacturing Capacity: Distribution by Size of Manufacturer
Table 19.37 Plasmid DNA Installed Manufacturing Capacity: Distribution by Range of Installed Capacity
Table 19.38 Plasmid DNA Installed Manufacturing Capacity: Distribution by Scale of Operation
Table 19.39 Plasmid DNA Installed Manufacturing Capacity: Distribution by Location of Manufacturing Facility
Table 19.40 Overall Viral Vectors and Plasmid DNA Installed Global Manufacturing Capacity: Distribution by Type of Vector
Table 19.41 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030 (USD Billion)
Table 19.42 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Type of Vector (AAV, Adenoviral, Lentiviral, Retroviral, Plasmid DNA, Other Viral Vectors) (USD Million)
Table 19.43 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.44 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Table 19.45 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Scale of Operation (Clinical / Commercial) (USD Million)
Table 19.46 Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.47 AAV Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.48 AAV Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Table 19.49 AAV Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.50 Adenoviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.51 Adenoviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Table 19.52 Adenoviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.53 Lentiviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.54 Lentiviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Table 19.55 Lentiviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.56 Retroviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.57 Retroviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Table 19.58 Retroviral Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.59 Plasmid DNA Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.60 Plasmid DNA Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others) (USD Million)
Table 19.61 Plasmid DNA Vectors Manufacturing Market for Commercial Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.62 Other Viral Vectors Manufacturing Market for Commercial Products, 2018-2030 (USD Million)
Table 19.63 AAV Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.64 AAV Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Table 19.65 AAV Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.66 Adenoviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.67 Adenoviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Table 19.68 Adenoviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.69 Lentiviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.70 Lentiviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Table 19.71 Lentiviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.72 Retroviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.73 Retroviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Table 19.74 Retroviral Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.75 Plasmid DNA Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy) (USD Million)
Table 19.76 Plasmid DNA Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Phase of Development (Phase I, Phase II, Phase III) (USD Million)
Table 19.77 Plasmid DNA Vectors Manufacturing Market for Clinical Products, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW) (USD Million)
Table 19.78 Other Viral Vectors Manufacturing Market for Clinical Products, 2018-2030 (USD Million)
Table 19.79 Survey Analysis: Distribution by Type of Organization
Table 19.80 Survey Analysis: Distribution by Location of Organization
Table 19.81 Survey Analysis: Distribution by Seniority Level of Respondents
Table 19.82 Survey Analysis: Distribution by Type of Vector
Table 19.83 Survey Analysis: Distribution by Scale of Production
Table 19.84 Survey Analysis: Vector Stabilization Technology
Table 19.85 Survey Analysis: Distribution by Purpose of Production (In-house Production v/s Contract Services)

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  • 4D Molecular Therapeutics
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Research Methodology

The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market may evolve across different regions and technology segments. Wherever possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include:

  • Annual reports
  • Investor presentations
  • SEC filings
  • Industry databases
  • News releases from company websites
  • Government policy documents
  • Industry analysts’ views

While the focus has been on forecasting the market over the period 2018-2030, the report also provides our independent view on various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

Chapter Outlines

Chapter 2 is an executive summary of the insights captured in our research. The summary offers a high-level view on the likely evolution of the viral vectors and plasmid DNA manufacturing market in the short to mid-term, and long term.

Chapter 3 is a general introduction to the various types of viral and non-viral vectors. It includes a detailed discussion on the design, manufacturing requirements, advantages, limitations and applications of currently available gene delivery vectors. The chapter also provides a brief description of the clinical and approved pipeline of genetically modified therapies. Furthermore, we have provided an overview of the latest trends and innovations in the current vector manufacturing market.

Chapter 4 provides a comprehensive overview of around 130 companies / organizations, featuring both contract service providers and in-house manufacturers that are actively involved in the production of viral vectors. The chapter provides details on the type of organization (industry / non-industry), year of establishment, geographic location of facilities and vector production capabilities, specifically focusing on the scale of operation, type of vectors manufactured and the purpose of vector production (fulfilling in-house requirement / contract service provider).

Chapter 5 provides a comprehensive overview of around 55 contract service providers / in-house manufacturers that are actively involved in the production of plasmid DNA. The chapter provides details on the type of organization (industry / non-industry), year of establishment, geographic location of facilities and, their vector production capabilities, specifically focusing on the scale of operation, type of vectors manufactured and the purpose of vector production (fulfilling in-house requirement / contract service provider).

Chapter 6 features detailed profiles of the contract service providers / in-house manufacturers based in the US that possess commercial scale capacities for production of viral vectors / plasmid DNA. Each profile presents a brief overview of the company, its financial performance (if available), details on vector manufacturing facilities, manufacturing experience, recent investments / expansions, relevant collaborations and partnerships that have been inked over the last few years, and a comprehensive future outlook.

Chapter 7 features detailed profiles of the contract service providers / in-house manufacturers based in EU that possess commercial scale capacities for the production of viral vectors / plasmid DNA. Each profile presents a brief overview of the company, its financial performance (if available), details on vector manufacturing facilities, manufacturing experience, recent investments / expansions, the relevant collaborations and partnerships that have been inked over the last few years, and a comprehensive future outlook.

Chapter 8 features detailed profiles of the contract service provider(s) / in-house manufacturer(s) based in the Asia Pacific that possess commercial scale capacities for production of viral vectors / plasmid DNA. Each profile presents a brief overview of the company, its financial performance (if available), details on vector manufacturing facilities, manufacturing experience, recent investments / expansions, the relevant collaborations and partnerships that have been inked over the last few years, and a comprehensive future outlook.

Chapter 9 offers detailed information on other viral / non-viral vectors (including alphavirus vectors, Bifidobacterium Longum vectors, Listeria monocytogenes vectors, myxoma virus based vectors, Sendai virus based vectors, self-complementary vectors (improved versions of AAV), and minicircle DNA and Sleeping Beauty transposon vectors (non-viral gene delivery approach) that are currently being utilized by pharmaceutical players to develop gene therapies, T-cell therapies and certain vaccines, as well. This chapter presents general information on all the aforementioned types of vectors, along with examples of companies that use them in their proprietary products. It also includes examples of companies that are utilizing specific technology platforms for the development / manufacturing of some of these novel vectors.

Chapter 10 features an elaborate analysis and discussion of the various collaborations and partnerships that have been inked amongst players related to the manufacturing of vectors or vector-based products. We have also discussed the different partnership models (including licensing agreements, mergers / acquisitions, product development agreements, service alliances, vector manufacturing agreements, and other popular deals / agreements) that have been adopted in this domain since 2015. It consists of a schematic representation showcasing the players that have established the maximum number of alliances related to the manufacturing of vectors. Furthermore, we have provided a world map representation of the deals inked in this field, highlighting those that have been established within and across different continents.

Chapter 11 presents a collection of key insights derived from the study. It includes a grid analysis, highlighting the distribution of viral vectors and plasmid DNA manufacturers on the basis of their scale of production and purpose of manufacturing (fulfilling in-house requirement / contract service provider). In addition, it consists of a logo landscape, representing the distribution of viral vector and plasmid DNA manufacturers based on the type of organization (industry / non-industry) and size of employee base. The chapter also consists of six world map representations of manufacturers of viral / non-viral vectors (lentiviral, adenoviral, AAV and retroviral vectors, and plasmid DNA), depicting the most active geographies in terms of the presence of the organizations. Furthermore, we have provided a schematic world map representation to highlight the locations of global vector manufacturing hubs across different continents.

Chapter 12 highlights our views on the various factors that may be taken into consideration while pricing viral vectors / plasmid DNA. It features discussions on different pricing models / approaches, which a manufacturer may choose to adopt to decide the price of its proprietary products.

Chapter 13 features a comprehensive analysis of the overall installed capacity of viral vector and plasmid DNA manufacturers. The analysis is based on meticulous data collection of reported capacities, via both secondary and primary research, of various small-sized, mid-sized and large-sized companies, distributed across their respective facilities. The results of this analysis were used to establish an informed opinion on the vector production capabilities of the organizations across different types of vectors (viral vectors, plasmid DNA, and both), scale of operation (clinical and commercial) and geographies (North America, EU, Asia Pacific and the rest of the world).

Chapter 14 presents a comprehensive market forecast analysis, highlighting the likely growth of the market of viral vectors and plasmid DNA till the year 2030. We have segregated the financial opportunity by type of vectors (AAV vector, adenoviral vector, lentiviral vector, retroviral vector, plasmid DNA and others), applications (gene therapy and T-cell therapy), therapeutic area (oncology, inflammation & immunology, neurological, ophthalmology, muscular, metabolic disorder, cardiovascular disorder and others), scale of operation (clinical, commercial and both) and geography (North America, EU, Asia Pacific and rest of the world). Due to the uncertain nature of the market, we have presented three different growth tracks outlined as the conservative, base and optimistic scenarios.

Chapter 15 provides details on the various factors associated with popular viral vectors and plasmid DNA that act as market drivers and the various challenges associated with the production process. This information has been validated by soliciting the opinions of several industry stakeholders active in this domain.

Chapter 16 presents insights from the survey conducted for this study. We invited over 150 stakeholders involved in the development of different types of gene therapy vectors. The participants, who were primarily Director / CXO level representatives of their respective companies, helped us develop a deeper understanding on the nature of their services and the associated commercial potential.

Chapter 17 summarizes the entire report. The chapter presents a list of key takeaways and offers our independent opinion on the current market scenario and evolutionary trends that are likely to determine the future of this segment of the industry.

Chapter 18 is a collection of interview transcripts of the discussions held with key stakeholders in the industry. We have presented details of interviews held with Joost van den Berg (Director, Amsterdam BioTherapeutics Unit), Semyon Rubinchik (Scientific Director, ACGT), Nicole Faust (Chief Executive Officer & Chief Scientific Officer, CEVEC Pharmaceuticals), Olivier Boisteau, (President / Co-Founder, Clean Cells), Laurent Ciavatti (Business Development Manager, Clean Cells), Xavier Leclerc (Head of Gene Therapy, Clean Cells), Colin Lee Novick (Managing Director, CJ Partners), Cedric Szpirer (Executive & Scientific Director, Delphi Genetics), Nicolas Grandchamp (R&D Leader, GEG Tech), Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital), Alain Lamproye (President of Biopharma Business Unit, Novasep), Astrid Brammer (Senior Manager Business Development, Richter-Helm), Marco Schmeer (Project Manager, Plasmid Factory), Tatjana Buchholz (Marketing Manager, Plasmid Factory), Jeffrey Hung (Chief Commercial Officer, Vigene Biosciences), and Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing).  

Chapter 19 is an appendix, which provides tabulated data and numbers for all the figures in the report.

Chapter 20 is an appendix, which contains the list of companies and organizations that have been mentioned in the report.

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  • 4D Molecular Therapeutics
  • AbbVie
  • Abeona Therapeutics
  • Acucela
  • Adaptimmune Therapeutics
  • Addgene
  • Aduro Biotech
  • Advanced BioScience Laboratories (ABL)
  • Advanced Biotherapeutics Consulting
  • Advaxis
  • Advent
  • Adverum Biotechnologies
  • Agenzia Italiana del Farmaco
  • Agilent Technologies
  • Agilis Biotherapeutics
  • Aldevron
  • Allele Biotechnology
  • Alma Bio Therapeutics
  • AlphaVax
  • Althea Technologies
  • American Gene Technologies
  • Amgen
  • AMSBIO
  • Amsterdam BioTherapeutics Unit
  • Anaeropharma Science
  • Applied Biological Materials
  • Applied Genetic Technologies (AGTC)
  • Applied Viromics
  • ARCO Design/Build
  • Areta International
  • Asklepios BioPharmaceutical
  • Atlantic Bio GMP
  • ATVIO Biotech
  • Audentes Therapeutics
  • Autolus
  • AveXis
  • Avista Capital Partners
  • Bamboo Therapeutics
  • Batavia Biosciences
  • Bavarian Nordic
  • Baxter
  • Beckman Research Institute
  • Belfer Gene Therapy Core Facility, Cornell University
  • Benitec Biopharma
  • BioCancell
  • Biogen
  • Biomay
  • Biomiga
  • BioReliance
  • Biotec Services International
  • Biotechnology Department of San Raffaele
  • Biotie Therapies
  • Bioverativ
  • BioVex
  • Biovian
  • Blue Sky BioServices
  • bluebird bio
  • B-MoGen Biotechnologies
  • Boehringer Ingelheim
  • Brammer Bio
  • BRC Clinical Research Facility and Cell Therapy Unit, King’s College London
  • Brewin Dolphin
  • Bristol-Myers Squibb
  • Brookside Capital
  • California Institute for Regenerative Medicine
  • California Institute of Technology
  • Calimmune
  • Cancer Research UK
  • Capsugel
  • Carnegie Institution for Science
  • Celgene
  • Cell and Gene Therapy Catapult
  • Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center
  • Celladon
  • Cellectis
  • Cellular Biomedicine Group
  • Center for Biomedicine & Genetics, City of Hope
  • Center for Cell and Gene Processing, Takara Bio
  • Center for Cell and Gene Therapy, Baylor College of Medicine
  • CEPiA Sanofi
  • CEVEC Pharmaceuticals
  • Chiesi Farmaceutici
  • Children's GMP (St. Jude Children's Research Hospital)
  • Children's Hospital of Philadelphia
  • CIEMAT
  • Cincinnati Children's Hospital Medical Center
  • Clean Cells
  • Clinical Biotechnology Centre, NHS Blood and Transplant
  • Clinical Vector Production Core, University of Pittsburgh
  • Cobra Biologics
  • CombiGene
  • Core Facility for Therapeutic Vectors, Institute of Medical Science Research Hospital
  • Cranfield University
  • Creative Biogene
  • Creed Commercial Development
  • Deerfield Management
  • Delphi Genetics
  • Department of Neuroscience, University of Minnesota
  • Desktop Genetics
  • DNAtrix
  • Elixirgen Scientific
  • Epeius Biotechnologies
  • EUFETS
  • Eurofins Genomics
  • European Society of Gene and Cell Therapy
  • Finnish Bioindustries
  • FinVector
  • Fisher BioServices
  • Five Prime Therapeutics
  • FKD Therapies
  • Florida Biologix
  • Fondazione Telethon
  • Foundation Fighting Blindness
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • Freeline Therapeutics
  • FUJIFILM Diosynth Biotechnologies
  • GEG Tech
  • Genable Technologies
  • Gene and Cell Therapy Lab, Institute of Translational Health Sciences
  • Gene Editing and Viral Vector Core, City of Hope
  • Gene Medicine Japan
  • Gene Therapy Research Institute
  • Gene Transfer Vector Core, Schepens Eye Research Institute
  • Gene Transfer, Targeting and Therapeutics Core, Salk Institute for Biological Studies
  • GeneCure Biotechnologies
  • GeneDetect
  • GeneImmune Biotechnology
  • Genethon
  • GENEWIZ
  • GenIbet Biopharmaceuticals
  • GenScript
  • GenVec
  • Genzyme
  • GIGA Institute, Liege Universite
  • Gilead Sciences
  • GlaxoSmithKline
  • Green Cross LabCell
  • GSEx, Robinson Research Institute, The University of Adelaide
  • Guy’s Hospital, London
  • Hercules Capital
  • Hong Kong Institute of Biotechnology
  • Hookipa Biotech
  • Hope Center Viral Vectors Core, Washington University School of Medicine
  • Horizon Discovery
  • Hospital de Sant Pau
  • Human Stem Cells Institute
  • ID Pharma
  • Immune Design
  • Immune Technology
  • ImmunoGenes
  • Immunomic Therapeutics
  • Inbiomed
  • Indiana University Vector Production Facility
  • Instituto de Tecnologia Química e Biológica António Xavier
  • Intrexon
  • InvivoGen
  • IPPOX Foundation
  • IQVIA Stem Cell Center
  • Janelia Research Campus
  • Janssen
  • Kalon Biotherapeutics
  • Kaneka Eurogentec
  • Kelley School of Business, Indiana University
  • King's College London, Guy’s and St Thomas’ NHS Foundation Trust
  • Kite Pharma
  • Kolon Life Sciences
  • Laboratory of Malaria Immunology and Vaccinology
  • LakePharma
  • Lentigen
  • Lentiviral Lab, USC School of Pharmacy
  • Leuven Viral Vector Core
  • Lonza
  • Luminous BioSciences
  • Lund University
  • Lysogene
  • Massachusetts Eye and Ear
  • Massachusetts Life Science Center
  • MassBiologics
  • MaxCyte
  • Medigene
  • MeiraGTx
  • Merck
  • Merck Serono
  • Merial
  • Michael J. Fox Foundation for Parkinson Research
  • Mila’s Miracle Foundation
  • MilliporeSigma
  • Ministry of Economy and Competitiveness
  • Mitsubishi
  • Molecular Diagnostic Services
  • MolMed
  • Myeloma Crowd Research Initiative
  • NanoCor Therapeutics
  • Nantes Gene Therapy Institute
  • National Cancer Institute
  • National Center for Advancing Translational Sciences
  • National Human Genome Research Institute
  • National Institutes of Health
  • Nature Technology
  • Naval Medical Research Center
  • Neuroscience CenterVector Core, Massachusetts General Hospital
  • Neuroscience Gene Vector and Virus Core, Stanford Medicine
  • NewLink Genetics
  • Novartis
  • Novasep
  • Ocular Gene Therapy Core, National Eye Institute
  • Okairos
  • Omnia Biologics
  • Orchard Therapeutics
  • Oxford BioMedica
  • Oxford Genetics
  • PacificGMP
  • Paragon Bioservices
  • Penn Vector Core, University of Pennsylvania
  • Pfizer
  • PharmaChem Technologies
  • Pinchal & Company
  • PlasmidFactory
  • Powell Gene Therapy Center, University of Florida
  • Protein Sciences
  • Provecs Medical
  • Puresyn
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia
  • Rayne Cell Therapy Suite, King's College London
  • REGENXBIO
  • Renova Therapeutics
  • Richter-Helm BioLogics
  • RIKEN BioResource Research Center
  • Roche
  • Rock Springs Capital
  • Rocket Pharmaceuticals
  • SAB-Technology
  • SAFC
  • Sanofi
  • Sartorius Stedim Biotech
  • Scancell
  • Selecta Biosciences
  • Shanghai Sunway Biotech
  • Shenzhen SiBiono GeneTech
  • SignaGen Laboratories
  • SillaJen
  • Sino Biological
  • SIRION Biotech
  • Sofinnova Ventures
  • Spark Therapeutics
  • St Thomas’ NHS Foundation Trust
  • Stanford University
  • Stevenage Bioscience Catalyst
  • Strathmann Biotec
  • Stratophase
  • Synpromics
  • Synthace
  • Synthetic Genomics
  • System Biosciences
  • T. Rowe Price Associates
  • Takara Bio
  • Tecrea
  • Texas A&M University
  • The Finnish Fair Foundation
  • The Goldyne Savad Institute of Gene Therapy, Hadassah Medical Organization
  • The Human Gene and Cell Therapy Center, Akdeniz University
  • The Jarvis Lab
  • The Wellcome Trust
  • TheraBiologics
  • THERAVECTYS
  • Therexsys
  • Thermo Fisher Scientific
  • TissueGene
  • Touchlight Genetics
  • Transgene
  • Treeway
  • Twist Bioscience
  • TxCell
  • UAB Vector Production Facility
  • uniQure
  • Unit Biotech & ATMP’s, University Medical Center Groningen
  • UniTech Pharma
  • University of Florida
  • University of Iowa Research Foundation
  • University of Liège
  • University of Massachusetts Medical School System
  • University of Oxford Clinical Biomanufacturing Facility
  • University of Virginia School of Medicine
  • Vaccibody
  • Vaccine and Gene Therapy Institute
  • Valneva
  • VBI Vaccine
  • Vectalys
  • Vector Biolabs
  • Vector Core / GMP Facility, UC Davis Health
  • Vector Core of Gene Therapy, Laboratory of Nantes
  • Vector Core, Harvard Gene Therapy Initiative
  • Vector Core, Telethon Institute of Genetics and Medicine
  • Vector Core, University of Michigan Medical School
  • Vector Core, University of North Carolina
  • Vecura GMP Laboratory, Karolinska Institutet
  • VGXI
  • Vibalogics
  • Vical
  • Vigene Biosciences
  • Viral Gene Transfer Core, Massachusetts Institute of Technology
  • Viral Vector Core / Clinical Manufacturing Facility, Nationwide Children's Hospital
  • Viral Vector Core, Carver College of Medicine, University of Iowa
  • Viral Vector Core, Duke University
  • Viral Vector Core, Emory University School of Medicine
  • Viral Vector Core, Jenner Institute
  • Viral Vector Core, Sanford Burnham Prebys Medical Discovery Institute
  • Viral Vector Core, University of Massachusetts Medical School
  • Viral Vector Facility, Neuroscience Center Zurich
  • Viral Vector Production Laboratory, Mayo Clinic Cancer Center
  • Viral Vector Production Unit, Universitat Autònoma de Barcelona-Vall d'Hebrón Institut de Recerca
  • ViralGEN
  • ViroMed
  • Virovek
  • VirusTech Core Facility, Karolinska Institutet
  • Vivante GMP Solutions
  • VIVEbiotech
  • Voyager Therapeutics
  • Waisman Biomanufacturing
  • Wellington Management
  • Wolfson Gene Therapy Unit, University College London
  • WuXi AppTec
  • Xpress Biologics
  • YPOSKESI
  • ZIOPHARM Oncology
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