New Frontiers in Cancer Therapies: Focus on Transcription Factors, GTPases, Phosphatases and GPCRs, 2018-2030

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Cancer therapeutics continues to be one of the most active segments, in terms of drug development efforts, within the pharmaceutical industry. In fact, in the past five years, USFDA has approved more than 70 drugs for the treatment of different types of cancer. However, there is still a pressing need to develop more specific and potent therapeutics to combat this complex, life threatening clinical condition. According to the National Institutes of Health, the economic burden of cancer care in the US was estimated to be over USD 147 billion in 2017. As the global population continues to increase, the number of cancer patients is likely to rise as well; by 2030, it is estimated that about 21.6 million people are likely to be newly diagnosed with the disease. Thereby, the overall global economic burden related to the disease is anticipated to increase significantly in the foreseen future.

Conventional cancer treatments, such as chemotherapy and radiation therapy are associated with several side effects. Their non-specific nature has been shown to have severe detrimental effects on patients’ quality of life. Current drug development initiatives are focused on targeted therapies against specific oncogenic mutations that are responsible for disease development and / or progression. Over the years, several targeted drugs have been designed against specific proteins, such as human epidermal growth factor (HER2), BCR-ABL protein kinase and vascular endothelial growth factor (VEGF). However, certain biological targets have long eluded drug development efforts and, for a considerable period of time, have been reported to be undruggable. One such target is Ras family, which has been identified to a play critical role in oncogenesis. Scientific literature suggests that the RAS gene is mutated across about 30% of cancer types; the mutation is known to be present in about 90% of pancreatic cancers, over 50% of colorectal cancers and 35% of lung cancers. Likewise, there are several other targets that have not yet been successfully drugged and researchers are making significant efforts to identify novel approaches to target them.

Advances in drug discovery and development technologies / platforms have increased the likelihood of targeting a number of the abovementioned types of biological targets. As a result, novel product development opportunities have emerged and are likely to benefit both drug developers and investors alike. Ongoing R&D is focused on the development of treatment modalities that can also combat complications, such as off target toxicities and disease relapse, which are associated with the current standard of care therapies. As various clinical stage candidates progress towards advanced stages of development, we expect the market to witness aggressive growth over the coming years.

The ‘New Frontiers in Cancer Therapies: Focus on Transcription Factors, GTPases, Phosphatases and GPCRs, 2018-2030’ report provides a comprehensive study on the current market and therapeutic potential of the various pharmacological interventions designed against difficult-to-modulate cancer targets. It features an elaborate discussion on the future potential of this evolving domain, focusing on phosphatases, transcription factors, small GTPases (specifically Ras family) and undruggable G-protein coupled receptors (GPCRs). One of the key objectives of the study was to review and quantify the future opportunity for the ongoing product development programs of both small and big pharmaceutical firms.

Amongst other elements, the report features:

  • A detailed assessment of the current market landscape of drugs being developed against various undruggable cancer targets, featuring information on the developer, phase of development (clinical, preclinical or discovery stage) of product candidate(s), information on type of molecule(s), biological target(s), mechanism of action, route of administration, and key therapeutic indication(s).
  • Elaborate profiles of key companies (selected based on pipeline strength); each profile features an overview of the company, details on it product portfolio, technology overview (wherever applicable), detailed information on advanced stage pipeline candidates (featuring a drug overview, clinical trial information and recent developments) and a comprehensive future outlook.
  • A section on emerging technologies and platforms that are aiding the development of therapies capable of targeting biological molecules which were previously considered as undruggable.
  • A detailed publication analysis on more than 70 research articles that have been published between January 2014 and March 2018, highlighting the key focus areas (biological targets and indications) of the ongoing research activity in this field.
  • An analysis of the partnerships that have been established in this domain in the recent past, covering R&D agreements, license agreements, clinical trial collaborations, mergers and acquisitions, and other relevant agreements.
  • An analysis of the investments made at various stages of development in companies that are focused in this area, including seed financing, venture capital financing, debt financing, grants, capital raised from IPOs and subsequent offerings.
  • A compilation of key insights derived based on various parameters; these include [A] a bull’s eye analysis highlighting the distribution of pipeline candidates in terms of phase of development, type of target family and type of molecule [B]a three-dimensional and five-dimensional spider web analyses of candidate therapeutics based on different parameters, namely number of publications, grants awarded to promote development, active clinical trials, current phase of development and the number of companies developing drugs against various undruggable targets, and [C] a world map representation, depicting the most active geographies in terms of the presence of companies developing drug candidates against difficult-to-modulate cancer targets.

One of the key objective of the report was to understand the primary growth drivers and estimate the future size of the market. Based on parameters, such as target consumer segments, likely adoption rates and expected pricing, we have provided an informed estimate of the likely evolution of the market in the short to long-term, for the period 2018 to 2030. To account for the uncertainties associated with the development of cancer therapeutics and to add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.

The research, analysis and insights presented in this report is backed by a deep understanding of insights gathered both from secondary and primary sources. The opinions and insights presented in this study were influenced by discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with Amotz Shemi (CEO, Silenseed), Brian Freznel (President and CEO, Tosk), Miguel Vega (CEO, Allinky Biopharma) and Stephen Franklin (CEO, Evgen Pharma). All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

Example Highlights

  • Over 100 product candidates are currently under various stages of development against difficult-to-modulate cancer targets. Of these, 75% of the candidates are in preclinical / discovery stages. Amongst the drugs that are under clinical development, 2 are in phase III, 5 in phase II, 5 in phase I/II and 12 in phase I. Drugs in advanced clinical evaluation (phase II and above) are napabucasin (phase III), Rigosertib™ (phase III), BL-8040 (phase II), CX-01 (phase II), danvatirsen (phase II), GI-6301 (phase II) and siG12D LODER (phase II).
  • A significant portion (~38%) of the drug candidates are being developed to target transcription factors, which play a critical role in a vast array of cellular processes and have been shown to be associated with several disease pathways. Prominent examples of transcription factors that have been shown to play a role in tumorigenesis include brachyury, Myc and STAT proteins. Another important target family is GTPases, primarily mutant Ras proteins, that are being targeted by about 28% of the pipeline candidates. Other key target families that are being investigated include GPCRs (such as CXCR4), phosphatases (such as SHP2 and PP2A) and certain complexes resulting from protein-protein interactions.
  • Small molecules, representing 48% of the present pipeline candidates, have emerged as one of the prominent drug classes being evaluated against difficult-to-modulate targets. Other important types of therapeutic molecules under development include peptides (12%), oligonucleotides (10%), proteins (9%) and antibodies (7%).
  • About 70% of the product candidates are being developed to treat solid tumors. Of these, pancreatic cancer (23%) is the most common; other popular indications include breast cancer (21%), lung cancer (19%) and colorectal cancer (16%). Further, about 30% of drugs are being developed for the treatment of hematological malignancies, such as acute myeloid leukemia, Burkitt lymphoma, myelodysplastic syndromes, non-Hodgkin lymphoma and multiple myeloma.
  • The market landscape is characterized by the presence of large (7), mid-sized (34) and small-sized companies (63), most of which are located in North America. The large companies involved in this domain include (in alphabetical order) AstraZeneca, BMS, Eli Lilly, Novartis and Pfizer. Similarly, mid-sized companies that are actively contributing to the development of these therapies include (with at least one molecule in the clinical phase of development) AndroScience, Boston Biomedical, Heptares Therapeutics, Ionis Pharmaceuticals, Polyphor, Silenseed and Taiho Oncology. In addition, small companies, such as (in alphabetical order) A2A Pharmaceuticals, FIMECS, Janpix, Navire Pharma, Oncternal Therapeutics, Orum Therapeutics, Ractigen Therapeutics, Sanoosa, SyntheX, TheraPten Biosciences and Zelluna Immunotherapy, are actively involved in this domain as well.
  • In order to advance the development efforts, stakeholders in the industry have forged several strategic partnerships. Over 50% of the agreements that have been signed since 2014 were related to the conduct of R&D activities. These were followed by licensing agreements (26%), clinical trial collaborations (9%), and product development (6%) and commercialization agreements (6%). Examples of recently inked deals include collaborations between FIMECS and Takeda Pharmaceutical (April 2018), Moleculin Biotech and University of Warsaw (March 2018), Onconova Therapeutics and Pint Pharma (March 2018), Moleculin Biotech and Emory University (March 2018), and Arvinas and Pfizer (January 2018).
  • More than 80 funding instances, amounting to USD 915 million worth of capital, have taken place in order to support R&D in this space since 2014. Alexandria Venture Investment and Fidelity Management & Research Company have emerged as some of the most prominent investors (in terms of number of financing instances). It is noteworthy to highlight that the NIH has provided financial support, in the form grants, to over 40 research projectsin the past two years.
  • Close to 70 players have designed and developed novel proprietary technology platforms to advance R&D efforts. Prominent examples of companies with technology platforms include (in alphabetical order) Allinky Biopharma, Aelin Therapeutics, Bio-Path Holdings, Captor Therapeutics, Eureka Therapeutics, FogPharma, InterAx, MiNA Therapeutics, Nuevolution, PHusis Therapeutics, Phylogica, Sanoosa, Silicon Therapeutics and SyntheX.
  • With several ongoing research initiatives and the likely approval of multiple late stage clinical candidates, the market is expected to witness an accelerated growth and be worth USD 5-6 billion over the coming decade. Specifically, by 2030, close to 70% of the market is likely to be driven by drugs targeting transcription factors, followed by GPCRs (~18%). The market, in the long term, is likely to be driven by five indications, namely pancreatic cancer (36%), colorectal cancer (14%), glioblastoma (12%), MDS (10%) and leukemia (10%). In terms of the geographical distribution, North America and the EU5 are expected to account for over 80% of the market.
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FEATURED COMPANIES

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  • Sirona Capital
  • MORE

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Chapter Overview
3.2. An Overview of Cancer
3.3. Treatment Modalities for Cancer
3.3.1. Targeted Therapies
3.4. Cancer Targets: Focus on transcription factors, GTPases, Phosphatases and G-Protein Coupled Receptors (GPCRs)
3.5. Types of Undruggable Cancer Targets
3.5.1. Transcription Factors
3.5.2. GTPases
3.5.3. Phosphatases
3.5.4. G-Protein Coupled Receptors (GPCRs)
3.6. Concluding Remarks

4. MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Overall Market
4.3. Clinical Pipeline
4.3.1. Analysis by Target Indication
4.3.2. Analysis by Type of Molecule
4.3.3. Analysis by Route of Administration
4.3.4. Analysis by Target Family
4.4. Preclinical Pipeline
4.4.1. Analysis by Target Indication
4.4.2. Analysis by Type of Molecule
4.4.3. Analysis by Target Family

5. COMPANY PROFILES
5.1. Chapter Overview
5.2. Boston Biomedical
5.2.1. Company Overview
5.2.2. Product Portfolio
5.2.3. Future Outlook
5.3. GLG Pharma
5.3.1. Company Overview
5.3.2. Product Portfolio
5.3.3. Future Outlook
5.4. GlobeImmune
5.4.1. Company Overview
5.4.2. Technology Overview
5.4.3. Product Portfolio
5.4.4. Future Outlook
5.5. Ionis Pharmaceuticals
5.5.1. Company Overview
5.5.2. Technology Overview
5.5.3. Product Portfolio
5.5.4. Future Outlook
5.6. Onconova Therapeutics
5.6.1. Company Overview
5.6.2. Product Portfolio
5.6.3. Future Outlook
5.7. Targovax
5.7.1. Company Overview
5.7.2. Technology Overview
5.7.3. Product Portfolio
5.7.4. Future Outlook

6. TECHNOLOGY LANDSCAPE
6.1. Chapter Overview
6.2. Drug Discovery Platforms
6.2.1. 3-Dimensional Bubble Analysis
6.3. Drug Development Platforms
6.4. Drug Delivery Platforms

7. PUBLICATION AND GRANT ANALYSIS
7.1. Chapter Overview
7.2. List of Publications
7.2.1. Analysis by Year of Publication
7.2.2. Analysis by Key Journals
7.2.3. Analysis by Popular Targets
7.2.4. Analysis by Popular Drug Classes
7.2.5. Analysis by Target Indications
7.3. List of Grants
7.3.1. Analysis by Types of Grants
7.3.2. Analysis by Key Research Areas
7.3.3. Analysis by Most Active Players

8. VENTURE FUNDING AND INVESTMENT ANALYSIS
8.1. Chapter Overview
8.2. Types of Funding
8.3. Funding and Investment Analysis
8.3.1. Analysis by Year of Funding Instances
8.3.2. Analysis by Amount Invested
8.3.3. Analysis by Type of Funding
8.3.4. Analysis by Number of Funding Instances: Most Active Players
8.3.5. Analysis by Number of Funding Instances: Most Active Investors
8.3.6. Analysis by Geography

9. PARTNERSHIP AND COLLABORATION ANALYSIS
9.1. Chapter Overview
9.2. Types of Partnership Models
9.3. Partnerships and Collaborations
9.3.1. Analysis by Year of Partnership
9.3.2. Analysis by Type of Partnership Model
9.3.3. Analysis by Key Focus Areas
9.3.4. Analysis by Number of Partnerships: Most Active Players

10. MARKET SIZING AND OPPORTUNITY ANALYSIS
10.1. Chapter Overview
10.2. Forecast Methodology
10.3. Overall Market, 2018-2030
10.3.1. Distribution by Target Indication
10.3.2. Distribution by Type of Molecules
10.3.3. Distribution by Type of Biological Target
10.3.4. Distribution by Target Family
10.3.5. Distribution by Route of Administration
10.3.6. Distribution by Geography
10.4. Product-wise Sales Forecast
10.4.1. Napabucasin
10.4.1.1. Target Patient Population
10.4.1.2. Sales Forecast
10.4.1.3. Net Present Value
10.4.2. Rigosertib™
10.4.2.1. Target Patient Population
10.4.2.2. Sales Forecast
10.4.2.3. Net Present Value
10.4.3. BL-8040 / BKT140
10.4.3.1. Target Patient Population
10.4.3.2. Sales Forecast
10.4.3.3. Net Present Value
10.4.4. CX-01
10.4.4.1. Target Patient Population
10.4.4.2. Sales Forecast
10.4.4.3. Net Present Value
10.4.5. Danvatirsen
10.4.5.1. Target Patient Population
10.4.5.2. Sales Forecast
10.4.5.3. Net Present Value
10.4.6. GI-4000
10.4.6.1. Target Patient Population
10.4.6.2. Sales Forecast
10.4.6.3. Net Present Value
10.4.7. GI-6301
10.4.7.1. Target Patient Population
10.4.7.2. Sales Forecast
10.4.7.3. Net Present Value
10.4.8. siG12D LODER
10.4.8.1. Target Patient Population
10.4.8.2. Sales Forecast
10.4.8.3. Net Present Value
10.4.9. GLG-801
10.4.9.1. Target Patient Population
10.4.9.2. Sales Forecast
10.4.9.3. Net Present Value
10.4.10. TG01
10.4.10.1. Target Patient Population
10.4.10.2. Sales Forecast
10.4.10.3. Net Present Value
10.4.11. X4P-001-IO
10.4.11.1. Target Patient Population
10.4.11.2. Sales Forecast
10.4.11.3. Net Present Value
10.4.12. WP1066
10.4.12.1. Target Patient Population
10.4.12.2. Sales Forecast
10.4.12.3. Net Present Value

11. KEY INSIGHTS
11.1. Chapter Overview
11.2. Key Cancer Targets: Analysis of Pipeline Candidates by Phase of Development and Target Family
11.3. Key Cancer Targets: Analysis of Pipeline Candidates by Type of Targets
11.4. Key Cancer Targets: Geographical Landscape of Developers

12. CONCLUSION
12.1. Extensive Research is Being Carried Out to Harness the Therapeutic Potential of Difficult-to-Modulate Targets
12.2. The Market is Characterized by a Robust Pipeline of Candidates Being Developed Against Targets Belonging to Different Protein Families
12.3. In Addition to Established Players, a Number of Start-ups are Making Significant Contributions in this Domain
12.4. Establishment of Several Partnerships and Support From Venture Capital Investors have Fostered Drug Development Efforts
12.5. Recent Advances have led to Development of Novel Technology Platforms that are Expected to Act as Vital Enablers of Growth
12.6. Post the Anticipated Approval of Multiple Late-phase Product Candidates, the Market is Anticipated to Grow Significantly in the Foreseen Future

13. INTERVIEW TRANSCRIPTS
13.1. Chapter Overview
13.2. Allinky Biopharma
13.2.1. Company Snapshot
13.2.2. Interview Transcript: Miguel Vega, Chief Executive Officer
13.1. Evgen
13.3.1. Company Snapshot
13.3.2. Interview Transcript: Stephen Franklin, Chief Executive Officer
13.3. Silenseed
13.3.1. Company Snapshot
13.3.2. Interview Transcript: Amotz Shemi, Chief Executive Officer
13.4. TOSK
13.4.1. Company Snapshot
13.4.2. Interview Transcript: Brian Frenzel, President and Chief Executive Officer

14. APPENDIX 1: TABULATED DATA

15. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS

LIST OF FIGURES
Figure 3.1 Biological Characteristics Exhibited by Cancer Cells
Figure 3.2 Types of Cancer Treatment
Figure 3.3 Difficult-to-Modulate Cancer Targets: Phosphatases
Figure 3.4 Difficult-to-Modulate Cancer Targets: Transcription Factors
Figure 3.5 Cell Proliferation Pathway of Normal and Mutant Ras Protein
Figure 3.6 Difficult-to-Modulate Cancer Targets: GPCRs
Figure 4.1 Overall Pipeline: Distribution by Phase of Development
Figure 4.2 Overall Pipeline: Distribution by Target Indication
Figure 4.3 Overall Pipeline: Distribution by Biological Target
Figure 4.4 Clinical Pipeline: Distribution by Target Indication
Figure 4.5 Clinical Pipeline: Distribution by Type of Molecule
Figure 4.6 Clinical Pipeline: Distribution by Route of Administration
Figure 4.7 Clinical Pipeline: Distribution by Target Family
Figure 4.8 Preclinical / Discovery Pipeline: Distribution by Target Indication
Figure 4.9 Preclinical / Discovery Pipeline: Distribution by Type of Molecule
Figure 4.10 Preclinical / Discovery Pipeline: Distribution by Target Family
Figure 5.1 Drug Developers: Competitive Landscape
Figure 5.2 Boston Biomedical: Product Portfolio
Figure 5.3 GLG Pharma: Product Portfolio
Figure 5.4 GlobeImmune: Product Portfolio
Figure 5.5 Ionis Pharmaceuticals: Product Portfolio
Figure 5.6 Onconova Therapeutics: Product Portfolio
Figure 5.7 Targovax: Product Portfolio
Figure 6.1 Technology Platforms: Distribution by Geography of Developer
Figure 6.2 Technology Platforms: Distribution by Type of Technology
Figure 6.3 Drug Discovery Platforms: 3-Dimensional Bubble Analysis
Figure 7.1 Publications: Year-wise Distribution
Figure 7.2 Publications: Popular Journals
Figure 7.3 Publications: Popular Targets
Figure 7.4 Publications: Popular Drug Classes
Figure 7.5 Publications: Target Indication
Figure 7.6 Grants: Types of Grants
Figure 7.7 Grants: Key Research Areas
Figure 7.8 Grants: Most Active Players
Figure 8.1 Funding Instances: Distribution by Year, 2014-2018
Figure 8.2 Funding Instances: Distribution of Amount Invested by Year, 2014-2018 (USD Million)
Figure 8.3 Funding Instances: Distribution by Type of Funding
Figure 8.4 Funding Instances: Distribution by Amount Invested and Type of Funding (USD Million)
Figure 8.5 Funding Instances: Most Active Players
Figure 8.6 Funding Instances: Most Active Investors
Figure 8.7 Funding Instances: Summary
Figure 8.8 Funding Instances: Distribution by Geography and Amount Invested
Figure 8.9 Funding Instances: Distribution by Geography and Number of Instances
Figure 8.10 Partnerships: Distribution by Year, 2014-2018
Figure 9.1 Partnerships: Distribution by Type of Collaboration
Figure 9.2 Partnerships: Distribution by Key Focus Areas
Figure 9.3 Partnerships: Most Active Players
Figure 10.1 Global Market, 2018-2030 (USD Billion)
Figure 10.2 Global Market: Distribution by Target Indication, 2025 and 2030
Figure 10.3 Global Market: Distribution by Type of Molecules, 2025 and 2030
Figure 10.4 Global Market: Distribution by Biological Targets, 2025 and 2030
Figure 10.5 Global Market: Distribution by Target Family, 2025 and 2030
Figure 10.6 Global Market: Distribution by Routes of Administration, 2025 and 2030
Figure 10.7 Global Market: Distribution by Geography, 2025 and 2030
Figure 10.8 Napabucasin Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.9 Rigosertib™ Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.10 BL-8040 / BKT140 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.11 CX-01 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.12 Danvatirsen Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.13 GI-4000 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.14 GI-6301 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.15 siG12D LODER Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.16 GLG-801 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.17 TG01 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.18 X4P-001-IO Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 10.19 WP1066 Sales Forecast (Till 2030): Base Scenario (USD Million)
Figure 11.1 Market Landscape: Distribution of Pipeline Candidates by Phase of Development, Target Family and Type of Molecule
Figure 11.2 Comparison of Cancer Targets: 3-Dimensional Bubble Analysis
Figure 11.3 Comparison of Cancer Targets: 5-Dimenional Spider-web Analysis
Figure 11.4 Market Landscape Most Prominent Hubs by Headquarters of Drug Developers
Figure 12.1 Logo Landscape of Drug Developers
Figure 12.2 Global Market: Conservative, Base and Optimistic Scenarios, 2025 and 2030

LIST OF TABLES
Table 3.1 Global Incidence of Cancer in 2020 and 2025
Table 3.2 Ras Mutations in Different Cancer Types (%)
Table 4.1 Clinical Pipeline
Table 4.2 Preclinical / Discovery Pipeline
Table 5.1 Boston Biomedical: Overview
Table 5.2 Napabucasin: Drug Profile
Table 5.3 GLG Pharma: Overview
Table 5.4 GlobeImmune: Overview
Table 5.5 GI-6301: Drug Profile
Table 5.6 Ionis Pharmaceuticals: Overview
Table 5.7 Danvatirsen: Drug Profile
Table 5.8 Onconova Therapeutics: Overview
Table 5.9 Rigosertib™: Drug Profile
Table 5.10 Targovax: Overview
Table 6.1 Drug Discovery Platforms
Table 6.2 3-Dimensional Bubble Analysis
Table 6.3 Drug Delivery and Drug Development Platforms
Table 7.1 List of Target Specific Publications, January 2014-February 2018
Table 7.2 List of Other Publications, January 2014-February 2018
Table 7.3 List of Grants, January 2017- March 2018
Table 8.1 Funding and Investments, 2014-2018
Table 8.2 Summary of Investments
Table 9.1 Recent Collaborations, 2014-2018
Table 10.1 Expected Launch Years of Advanced Stage Drug Candidates
Table 10.2 Napabucasin: Target Patient Population
Table 10.3 Napabucasin: NPV Evaluation
Table 10.4 Rigosertib™: Target Patient Population
Table 10.5 Rigosertib™: NPV Evaluation
Table 10.6 BL-8040 / BKT140: Target Patient Population
Table 10.7 BL-8040 / BKT140: NPV Evaluation
Table 10.8 CX-01: Target Patient Population
Table 10.9 CX-01: NPV Evaluation
Table 10.10 Danvatirsen: Target Patient Population
Table 10.11 Danvatirsen: NPV Evaluation
Table 10.12 GI-4000: Target Patient Population
Table 10.13 GI-4000: NPV Evaluation
Table 10.14 GI-6301: Target Patient Population
Table 10.15 GI-6301: NPV Evaluation
Table 10.16 siG12D LODER: Target Patient Population
Table 10.17 siG12D LODER: NPV Evaluation
Table 10.18 GLG-801: Target Patient Population
Table 10.19 GLG-801: NPV Evaluation
Table 10.20 TG01: Target Patient Population
Table 10.21 TG01: NPV Evaluation
Table 10.22 X4P-001-IO: Target Patient Population
Table 10.23 X4P-001-IO: NPV Evaluation
Table 10.24 WP1066: Target Patient Population
Table 10.25 WP1066: NPV Evaluation
Table 11.1 3-Dimensional Bubble Analysis
Table 11.2 6-Dimensional Spider-Web Analysis
Table 13.1 Allinky Biopharma: Company Snapshot
Table 13.2 Silenseed: Company Snapshot
Table 13.3 Tosk: Company Snapshot
Table 14.1 Overall Pipeline: Distribution by Phase of Development
Table 14.2 Overall Pipeline: Distribution by Target Indication
Table 14.3 Overall Pipeline: Distribution by Biological Target
Table 14.4 Clinical Pipeline: Distribution by Target Indications
Table 14.5 Clinical Pipeline: Distribution by Type of Molecules
Table 14.6 Clinical Pipeline: Distribution by Routes of Administration
Table 14.7 Clinical Pipeline: Distribution by Target Family
Table 14.8 Preclinical / Discovery Pipeline: Distribution by Target Indication
Table 14.9 Preclinical / Discovery Pipeline: Distribution by Types of Molecule
Table 14.10 Preclinical / Discovery Pipeline: Distribution by Target Family
Table 14.11 Publications: Year-wise Distribution
Table 14.12 Publications: Popular Journals
Table 14.13 Publications: Popular Targets
Table 14.14 Publications: Popular Drug Classes
Table 14.15 Publications: Target Indication
Table 14.16 Grants: Type of Grant
Table 14.17 Grants: Key Research Areas
Table 14.18 Grants: Most Active Players
Table 14.19 Funding Instances: Distribution by Year, 2014-2018
Table 14.20 Funding Instances: Distribution of Amount Invested by Year, 2014-2018 (USD Million)
Table 14.21 Funding Instances: Distribution by Type of Funding
Table 14.22 Funding Instances: Distribution by Amount Invested and Type of Funding (USD Million)
Table 14.23 Funding Instances: Most Active Players
Table 14.24 Funding Instances: Most Active Investors
Table 14.25 Funding Instances: Summary
Table 14.26 Funding Instances: Distribution by Geography and Amount Invested
Table 14.27 Funding Instances: Distribution by Geography and Number of Instances
Table 14.28 Partnerships: Distribution by Type of Collaboration, 2014-2018
Table 14.29 Partnerships: Distribution by Key Focus Area, 2014-2018
Table 14.30 Partnerships: Most Active Players
Table 14.31 Global Market: Conservative, Base and Optimistic Scenarios, 2018-2030 (USD Billion)
Table 14.32 Global Market: Distribution by Target Indication, 2025 and 2030
Table 14.33 Global Market: Distribution by Types of Molecule, 2025 and 2030
Table 14.34 Global Market: Distribution by Type of Biological Targets, 2025 and 2030
Table 14.35 Global Market: Distribution by Target Family, 2025 and 2030
Table 14.36 Global Market: Distribution by Routes of Administration, 2025 and 2030
Table 14.37 Global Market: Distribution by Geography, 2025 and 2030
Table 14.38 Napabucasin Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.39 Rigosertib™ Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.40 BL-8040 / BKT140 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.41 CX-01 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.42 Danvatirsen Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.43 GI-4000 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.44 GI-6301 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.45 siG12D LODER Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.46 GLG-801 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.47 TG01 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.48 X4P-001-IO Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)
Table 14.49 WP1066 Sales Forecast (Till 2030): Conservative, Base and Optimistic Scenarios (USD Million)

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FEATURED COMPANIES

  • 1Globe Health Institute
  • Bristol-Myers Squibb
  • Enzon Pharmaceuticals
  • Kymab
  • OncoViRx
  • Sirona Capital
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Research Methodology

The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include:

  • Annual reports
  • Investor presentations
  • SEC filings
  • Industry databases
  • News releases from company websites
  • Government policy documents
  • Industry analysts’ views

While the focus has been on forecasting the market over the coming twelveyears, the report also provides our independent view on various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

Chapter Outlines

  • Chapter 2 provides an executive summary of the insights captured during our research. It offers a high-level view on the likely evolution of the drugs against difficult-to-modulate targets to treat various cancer indications in the mid to long term.
  • Chapter 3 provides a general overview of certain biological targets (along with descriptions of the broader target families) that are considered as un druggable, and associated with various cancers. In addition, it features information on the currently available treatment modalities that are used to treat cancers. The chapter also highlights the key benefits offered by various targeted anti-cancer therapies. The focus of the report is on difficult-to-modulate phosphatases, transcription factors, small GTPases (specifically Ras family) and GPCRs.
  • Chapter 4 provides a comprehensive overview of the current landscape of therapies against difficult-to-modulate cancer targets. It includes information on over 100 drug candidates that are currently in various stages of (clinical / preclinical) development. It features a comprehensive analysis of the various pipeline molecules, highlighting affiliated drug developers, phase(s) of development, type of molecule, biological target, target protein family, target therapeutic indication(s), mechanism of action and route of administration.
  • Chapter 5 contains detailed profiles of active players (selected based on pipeline strength) that are involved in developing therapeutics against difficult-to-modulate targets. Each profile includes an overview of the company, its technology (wherever available) and details of its product portfolio. In addition, we have profiled the advanced phase drugs (phase II and above) that are in the pipeline of each of the companies included in this section. Drug profiles contain information on clinical development status, clinical trial details and recent developments.
  • Chapter 6 provides a list of technologies / platforms that have been developed to discover and / or develop therapeutics against various difficult-to-modulate cancer targets. It features a comparative analysis of the technologies, based on ongoing development activity related to a specific technology (in terms of number of drugs across different phases of development), number of partnerships established related to the technology and the size of the company. In addition, the chapter features a detailed logo landscape of various types of technology providers, distributed on the basis of their respective geographical locations.
  • Chapter 7 features a publication analysis highlighting the recent trends related to undruggable cancer targets in published literature. The chapter provides details on novel methods, as well as the attempts that are being made to add value to ongoing research efforts within this domain. In addition, it provides details on the various grants received by different organizations between 2017 to 2018.
  • Chapter 8 presents details on investments made into companies that are engaged in this domain. It includes a detailed analysis of the various funding instances that have taken place in the period between January 2014 to April 2018, highlighting the growing interest of the venture capital community and other strategic investors in this market.
  • Chapter 9 features an elaborate discussion and analysis of the various collaborations and partnerships that have been inked amongst stakeholders in this market. In this section, we have also described the different partnership models (including R&D agreements, technology / product licensing agreements, product development and commercialization agreements, clinical trial collaborations and merger / acquisitions) adopted by collaborating entities, highlighting the most common forms of deals / agreements that have been established in the period between 2014 to 2018.
  • Chapter 10 presents a comprehensive market forecast analysis, highlighting the future potential of the market till the year 2030. It includes sales projections of therapies against difficult-to-modulate cancer targets that have progressed to advanced clinical stages of development (phase I/II and above). The projections take into consideration the target patient population, likely adoption rates, existing / future competition from competing drug classes and the likely price of products. The chapter also presents a detailed market segmentation on the basis of target family, type of molecule, key therapeutic indications and geographical distribution. In addition, it provides information on the net present value of the aforementioned drug candidates.
  • Chapter 11 is a compilation of key insights derived from the study. It presents a review of the regional landscape of companies engaged in developing therapeutics for undruggable targets, based on their location and cumulative pipeline strength. The chapter also features a bull’s eye analysis, representing the distribution of drug candidates on the basis of their phase of development, target protein family and type of molecule. Additionally, the chapter features a spider-web analysis and bubble analysis, which highlight the activity of difficult-to-modulate targets. The parameters considered for these analyses include number of drug candidates, active clinical trials, publications, target indications and the companies that are involved in this domain.
  • Chapter 12 is a summary of the overall report. In this chapter, we have provided a list of key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.
  • Chapter 13 is a collection of interview transcripts of the discussions that were held with key stakeholders in this market. The chapter provides details of interviews held with Amotz Shemi (CEO, Silenseed), Brian Freznel (President and CEO, Tosk) Miguel Vega (CEO, Allinky Biopharma) and Stephen Franklin (CEO, Evgen Pharma).
  • Chapter 14 is an appendix, which provides tabulated data and numbers for all the figures included in the report.
  • Chapter 15 is an appendix, which provides the list of companies and organizations mentioned in the report.
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  • 1Globe Health Institute
  • 5AM Ventures
  • A2A Pharmaceuticals
  • AbbVie Ventures
  • Abilita Bio
  • AdAlta
  • Advent Life Sciences
  • Agence Nationale de la Recherche
  • Aileron Therapeutics
  • Akcea Therapeutics
  • Alaska Permanent Fund
  • Alexandria Venture Investments
  • Allergan
  • Allinky Biopharma
  • Alta Life Sciences
  • Amadeus Capital Partners
  • AndroScience
  • Anima Biotech
  • Aptose Biosciences
  • ARCH Venture Partners
  • Arrakis Therapeutics
  • Arrowhead Pharmaceuticals
  • Arvinas
  • Aspire Capital Partners
  • Astellas Pharma
  • AstraZeneca
  • Aurigene Discovery Technologies
  • Avergen Pharmaceuticals
  • Baxter Healthcare
  • Bayer
  • Baylor College of Medicine
  • Belfer CentreInstitute
  • BeyondSpring Pharmaceuticals
  • Biogen
  • BioLineRx
  • Bio-Path Holdings
  • Blueprint Medicines
  • Boston Biomedical
  • Boxer Capital
  • BridgeBio Pharma
  • Bristol-Myers Squibb
  • Broad Institute
  • BVF Partners
  • California Institute of Technology
  • Cambridge Enterprise
  • Canaan Partners
  • Canaccord Genuity
  • Cancer Research UK
  • Cantex Pharmaceuticals
  • Captor Therapeutics
  • Carmot Therapeutics
  • Casdin Capital
  • Celgene
  • Centre for the Development of Industrial Technology
  • ChinaBio® Group
  • Circa Group
  • Circle Pharma
  • Clarus Securities
  • Cloud Pharmaceuticals
  • Codiak BioSciences
  • Cold Spring Harbor Laboratory
  • Columbia University
  • Commonwealth Scientific and Industrial Research Organisation
  • Complix
  • Confo Therapeutics
  • Cormark Securities
  • Cormorant Asset Management
  • Cosmo Bio
  • Cotinga Pharmaceuticals
  • CPS Capital
  • CytomX Therapeutics
  • D&D Securities
  • Dana-Farber Cancer Institute
  • Dementia Discovery Fund
  • Department of Health and Human Services,United States
  • Dicerna Pharmaceuticals
  • Dual Therapeutics
  • EBD Group
  • EcoR1 Capital
  • Elements Capital Partners
  • Eli Lilly and Company
  • Emory University
  • Enzon Pharmaceuticals
  • EpiCypher
  • Escend Pharmaceuticals
  • Eureka Therapeutics
  • EvoRx Technologies
  • Fidelity Management & Research Company
  • FIMECS
  • Flagship Pioneering
  • Flagship Pioneering
  • Frederick National Laboratory for Cancer Research
  • GBO, a joint venture of Onconova Therapeutics and GVK Biosciences
  • Genentech
  • Glactone Pharma
  • GLG Pharma
  • GlobeImmune
  • GlycoMimetics
  • GlaxoSmithKline
  • GVK Biosciences
  • H. Lee Moffitt Cancer Center & Research Institute
  • Hatteras Venture Partners
  • HealthCap
  • HealthEquity
  • Heptares Therapeutics
  • Indi Molecular
  • Innovate UK
  • Innovation Norway
  • InterAx Biotech
  • InteRNA Technologies
  • Intervest
  • Inventiva
  • IOCB Tech
  • Ionis Pharmaceuticals
  • Iproteos
  • IRB Barcelona
  • Janpix
  • Janssen Pharmaceutica
  • Jennings Capital
  • Jesse Brown VA Medical Center
  • KB Investment
  • Kura Oncology
  • Kymab
  • Kymera Therapeutics
  • LA CELL
  • LB Investment
  • LGC
  • LGC LINK
  • LifeForce Capital
  • Lincoln Park Capital Fund
  • Lixte Biotechnology Holdings
  • Macroceutics
  • Marina Biotech
  • Massachusetts General Hospital
  • Massachusetts Institute of Technology
  • MecRx
  • Medicxi
  • Merck Sharp & Dohme
  • Methodist Hospital Research Institute
  • MiNA Therapeutics
  • Mirati Therapeutics
  • Mission Bay Capital
  • Moderna Therapeutics
  • Moleculin Biotech
  • MP Healthcare Venture Management
  • NantKwest
  • NanoProteagen
  • NantCell
  • NantWorks
  • National Cancer Institute
  • National Center for Regenerative Medicine
  • National Health and Medical Research Council
  • National Institute of Biomedical Imaging and Bioengineering
  • National Institute of General Medical Sciences
  • National Institute of Neurological Disorders and Stroke
  • National Institutes of Health
  • National OncoVenture
  • National Research Council Canada
  • Navire Pharma
  • New Leaf Venture Partners
  • New York University
  • Nextech Invest
  • Nomura Research Group
  • Norwegian Radium Hospital Research Foundation
  • Novartis
  • Novartis Institutes for BioMedical Research
  • Nuevolution
  • O2h Ventures
  • Ohio State University
  • Olivia Newton-John Cancer Research Institute
  • OncoFusion Therapeutics
  • Onconova Therapeutics
  • OncoViRx
  • Oncternal Therapeutics
  • OrbiMed
  • Oregon State University
  • Orum Therapeutics
  • Osage University Partners
  • Oslo Cancer Cluster
  • Parkwalk Advisors
  • Partner Fund Management
  • Partners for Development Investments in Life Sciences
  • Partnership Fund for New York City
  • PEP-Therapy
  • Peptomyc
  • Permeon Biologics
  • Pfizer
  • PhoreMost
  • PHusis Therapeutics
  • Phylogica
  • Pint Pharma
  • Polyphor
  • PowerOne Capital Markets
  • Proteros Biostructures
  • Purdue Institute for Drug Discovery
  • Qatar Investment Authority
  • RA Capital Management
  • Ractigen Therapeutics
  • RBC Capital Markets
  • Redx Pharma
  • Revolution Medicines
  • Ribometrix
  • Roche
  • Rockefeller Institute
  • ROTH Capital Partners
  • Sanford Burnham Prebys Medical Discovery Institute
  • Sanofi
  • Sanoosa
  • Scripps Research Institute
  • SEngine Precision Medicine
  • Seventure Partners
  • ShangPharma Investment Group
  • Silenseed
  • Silicon Therapeutics
  • Singh Biotechnology
  • Sirona Capital
  • Sloan-Kettering Institute for Cancer Research
  • Solidus Investment
  • Sosei Group
  • Spanish Ministry of Economy and Competition
  • StemMed
  • Sumitomo Dainippon Pharma
  • SupremeCure Pharma
  • SV Health Investors
  • Syndax Pharmaceuticals
  • SyntheX
  • Taiho Oncology
  • Takeda Pharmaceuticals
  • Targovax
  • Telethon Kids Institute
  • TetraGene
  • Tetragenetics
  • The Sapkota Laboratory
  • The University of Texas MD Anderson Cancer Center
  • The Wistar Institute
  • TheraPten Biosciences
  • Tokalas
  • Tokyo University of Science
  • Tosk
  • TriBiotica
  • United States Patent and Trademark Office
  • University of Barcelona
  • University of Basel
  • University of Bergen
  • University of California, Berkeley (Nomura Research Group)
  • University of California, San Francisco
  • University of Cambridge
  • University of Chicago
  • University of Dundee
  • University of Kansas, Lawrence
  • University of Minnesota, Twin Cities
  • University of North Carolina, Chapel Hill
  • University of Pennsylvania
  • University of South Florida
  • University of Texas Southwestern Medical Center
  • University of Tokyo
  • University of Toronto
  • University of Utah
  • University of Warsaw
  • University of Washington
  • United States Department of Veterans Affairs
  • United States Food and Drug Administration
  • VA Greater Los Angeles Healthcare System
  • Vinnova
  • Virginia Commonwealth University
  • Vitae Pharmaceuticals
  • Vividion Therapeutics
  • Warp Drive Bio
  • Whitehead Institute for Biomedical Research
  • Whitesun Healthcare Ventures
  • WI Harper Group
  • X4 Pharmaceuticals
  • Yale University
  • Zelluna Immunotherapy
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