Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and growth and development in early life. This important resource highlights serotonin's role in normal (unstressed) conditions and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. It also compares and contrasts physiological effects of brain and blood serotonin systems. Included is new data that suggests the influence of serotonin is in part through the regulation of gene expression - this includes important proteins within the serotonin system itself, as well as proteins in interacting neurotransmitter systems. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension; and provides compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS).
- Includes the latest information on new animal models of serotonin system dysfunction
- Explores the wide scope of serotonin's influence on multiple organ and physiological systems
- Highlights the autonomous functioning of the brain and body serotonin systems
- Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy
BIOPHYSICS OF SEROTONIN 1. Biophysics of Serotonin and the Serotonin1A Receptor: Fluorescence and Dynamics 2. Serotonin in plants: origin, function, and implications
ANATOMY 3. The anatomy of the serotonin system in different model systems: rat fish, flies and C. Elegans 4. Serotonin in the endocrine pancreas 5. Serotonin and platelets 6. Anatomy of the Serotonin Transporter
PHYSIOLOGY IN THE PERIPHERY 7. Cellular regulation of peripheral serotonin 8. Role of 5-HT in the control of gut motility 9. Phenotype of animals deficient in peripheral serotonin 10. Serotonin and immune system 11. Serotonin and Adipocyte Function 12. Serotonin and cardiovascular diseases 13. Involvement of 5-HT in afferent modulation of brainstem circuits regulating cardiovascular homeostasis 14. Regulation of nociceptor signalling by serotonin
PHYSIOLOGY IN THE BRAIN 15. Brain serotonin and energy homeostasis 16. Serotonin in central cardiovascular control 17. Serotonin receptors and cardiovascular control 18. Serotonin receptors as the therapeutic target for central nervous system disorders 19. Serotonin and the reconfiguration of the eupneic respiratory pattern 20. Life without brain serotonin: phenotype of animals deficient in central serotonin synthesis
Paul M Pilowsky began his career as a graduate student investigating, inter alia, the role of brainstem and spinal cord pathways in the control of blood pressure with a focus on serotonin. His work has now been cited more than 5000 times and published in major Journals including the Journal of Neuroscience, the Journal of Comparative Neurology and the British Journal of Pharmacology. A hallmark of his work has been the adoption of, and combination of, novel approaches to address difficult questions. He pioneered the use of combining single cell electrophysiology in vivo with immunohistochemistry. His development of isotype selective monoclonal antibodies to phosphorylated tyrosine hydroxylase enabled the detection of tyrosine hydroxylase positive presympathetic neurons in the brainstem that had become excited.
He was responsible for the initial development of a new medical school at Macquarie University in Sydney. His service to Neuroscience was recognised by the award of the Australian Neuroscience Medal. He mentored 26 graduate students to on-time completion, and mentored 24 post-Doctoral Fellows, many of whom now have their own established careers.
In imagining this book, it was felt that a departure from the usual highly focussed text would be of interest. Hence, a multi-Author volume has been created that reveals the multiple facets of a neurotransmitter with very broad actions.