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Frontiers in Anti-Infective Drug Discovery: Volume 7

  • ID: 4582132
  • Book
  • May 2018
  • Bentham Science Publishers Ltd

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.

Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.

The seventh volume of this series features 7 chapters that cover the following topics:

  • Gut micriobiota and gastrointestinal cancer
  • Dengue virus infections
  • Synergistic antibiotic drug interactions
  • Molecular modelling of antibacterial drugs
  • Nucleic acid aptamers as anti-infective agents
  • Fungal multidrug resistance
  • The role of hydrogen sulfide in infections
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Chapter 1 The Role Of The Microbiota In The Genesis Of Gastrointestinal Cancers 

  • Edda Russo And Amedeo Amedei
  • Introduction
  • The Human Microbiota
  • The Gastrointestinal Microbiota
  • Composition And Activities
  • Gastro-Intestinal Colonization By The Microbiota And Selection
  • The Human Microbiome Project
  • Gut Enterotypes
  • The Role Of Microbiota In Tumor Development
  • Proposed Models For Microbiota-Induced Carcinogenesis
  • Antibacterial-Specific Immune Response And Cancer Promotion
  • Microbiota And Gi Cancers
  • Gut Bacteria Dysbiosis Associated With Gi Cancer
  • Microbiota Involvement In Gastric And Esophageal Cancers, The Role Of Helicobacter Pylori
  • Microbiota Involvement In Colorectal Cancer
  • Specific Gut Bacteria And Crc
  • Bacteria Metabolites And Crc
  • Gallbladder Cancer
  • Liver Cancer
  • Pancreatic Cancer
  • Beneficial Activities Of Gut Microbiota
  • Antitumorigenic Impact Of Microbiota
  • Manipulating The Microbiota For Cancer Therapy
  • Conclusion
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References

Chapter 2 Towards Host Cell-Targeting Therapies To Treat Dengu Virus Infections 

  • Cybele C García, Verónica M Quintana, Viviana Castilla And Elsa B Damonte
  • Introduction
  • Interaction With Cell Receptors
  • Endocytosis And Fusion For Uncoating
  • Lipid Metabolism
  • Protein Translation
  • Unfolded Protein Response
  • Ubiquitin Proteasome Pathway
  • Nucleotide Metabolism
  • Kinases
  • Mitogen-Activated Protein Kinases
  • Erk Pathway
  • Jnk Pathway
  • P38 Pathway
  • Other Kinases
  • Src, Ab1 And Fyn Kinases
  • Ap2-Associated Protein Kinase 1 And Cyclin G-Associated Kinase
  • Phosphatidylinositol 3 Kinase/Akt Pathway
  • Protein Processing
  • Endoplasmic Reticulum A-Glucosidases
  • Furin
  • Endoplasmic Reticulum Associated Signal Peptidase
  • Innate Antiviral Response
  • Interferon Activity
  • Cell-Intrinsic Restriction Factors
  • Concluding Remarks
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References

Chapter 3 Synergistic Interaction Between Plant Products And Antibiotics Against Potential Pathogenic Bacteria 

  • Banasri Hazra, Sutapa Biswas Majee, Subhalakshmi Ghosh And Dhruti Avlani
  • Introduction
  • Bacterial Resistance Towards Clinical Antibiotics
  • Background
  • Mechanisms And Associated Factors
  • Screening Strategies To Characterise Plant Products With
  • Potential Resistance Modifying Activity
  • Assessment Of Synergistic Interaction Between Antibiotic And A
  • Phytocompound Against Resistant Bacteria
  • Fractional Inhibitory Concentration Index (Fici)
  • Modulation Factor (Mf)
  • Isobologram
  • Search For Plant-Derived Secondary Metabolites With
  • Prospective Resistance Modifying Activity
  • Key Early Studies Pertaining To Discovery Of Rmas From Plants
  • Recent Studies
  • Phytochemicals And Relevant Bacterial Resistance Mechanisms
  • Efflux Pump Inhibition
  • Alteration Of Bacterial Cell Membrane Permeability
  • Protein Synthesis Inhibition
  • Enzymatic Inhibition
  • Biofilm Formation Inhibition
  • Additional Strategies For Screening And Development Of Plant
  • Products As Adjuvants In Antimicrobial Therapy
  • In Vivo Validation
  • Standardisation Of Botanical Extracts
  • Ichip Technology
  • Concluding Remarks
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • Abbreviations
  • References

Chapter 4 Molecular Modelling Approaches To Antibacterial Drug Design And Discovery 

  • Agnieszka A Kaczor, Prasanthi Medarametla, Damian Bartuzi, Magdalena Kondej,
  • Dariusz Matosiuk And Antti Poso
  • Introduction
  • Challenges In Design And Discovery Of Antibacterial Drugs
  • Drug Targets For Antibiotics
  • Molecular Modelling Techniques For Design And Discovery Of
  • Antibacterial Drugs
  • Protein 3D Structure Prediction
  • Comparative/Homology Modelling
  • Fold Recognition/Threading
  • Ab Initio Modelling
  • Protein Structure Prediction In Anti-Bacterial Drug Design
  • Molecular Docking
  • Molecular Docking As An Approach To Study Ligand-Protein Interactions
  • Application Of Molecular Docking In Anti-Bacterial Drug Discovery
  • Molecular Dynamics
  • Molecular Dynamics As An Approach To Study Dynamic Aspects Of Ligand-Protein
  • Interactions
  • Application Of Molecular Dynamics For Antibacterial Drug Discovery
  • Qsar
  • Qsar As A Method Applied In Drug Design
  • Application Of Qsar For Antibacterial Drug Discovery
  • Pharmacophore Models
  • Importance Of Pharmacophore Models In Drug Design
  • Application Of Pharmacophore Models For Antibacterial Drug Discovery
  • Virtual Screening
  • Virtual Screening As A Method Of Searching Large Databases
  • Application Of Virtual Screening For Antibacterial Drug Discovery
  • Prediction Of Drug-Likeness And Admet Properties
  • Summary And Perspective
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References

Chapter 5 Nucleic Acid Aptamers Against Virulence Factors Of Drug Resistant Pathogens 

  • Canan Ozyurt, Ozge Ugurlu, Burhan Bora And Serap Evran
  • Introduction
  • Selection Of Aptamers
  • Aptamers Against Toxins And Protein Virulence Factors
  • Aptamers Against Staphylococcal Toxins
  • Aptamers Against Clostridium Toxins
  • Aptamers Against E Coli Toxins
  • Aptamers Against Aspergillus And Penicillium Toxins
  • Aptamers Against Mycobacterium Tuberculosis Toxins
  • Aptamers Against Other Toxins
  • Aptamers Against Quorum Sensing Molecules
  • Modifications Of Aptamers For Improving Therapeutic Potential
  • 2'-F-Modified Rna Aptamers
  • 2'-Nh2 Modification Of Aptamers
  • Other Ribose Modified Aptamers
  • Phosphorothioate Modification
  • Nucleobase Modification Of Aptamers
  • Concluding Remarks
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgement
  • References

Chapter 6 Overcoming Fungal Multidrug Resistance By Natural Compounds Targeting Efflux Pumps 

  • Shweta Singh, Sandeep Hans, Zeeshan Fatima
  • And Saif Hameed
  • Introduction
  • Candida Efflux Pumps
  • Abcs Transporter Family
  • Mfs Transporter Family
  • Natural Epi Targeting Abc Transporters
  • Natural Epi Targeting Mfs Transporters
  • Conclusion
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References

Chapter 7 The Infections And Hydrogen Sulfide 

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  • Atta-ur-Rehman
  • Iqbal Chaudhry
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