Nanomaterials for Magnetic and Optical Hyperthermia Applications. Micro and Nano Technologies

Table of Contents

Part 1. Introduction to hyperthermia 1. Basic concepts of hyperthermia 2. Cellular response to heat stress 3. Hyperthermia for combined cancer therapy 4. Current status of clinical trials in hyperthermia 5. Hyperthermia at the nanoscale why nanomaterials? 6. Fundamentals of magnetic and optical hyperthermia

Part 2. Magnetic hyperthermia 1. Interaction of magnetic nanoparticles with alternating magnetic fields (Q. Pankhurst) 2. Mechanisms of magnetic heat generation (Q. Pankhurst, T. Pellegrino) 3. Design and synthesis of MNPs for hyperthermia applications 4. In vitro magnetic hyperthermia: influence of subcellular localization of magnetic nanoparticles on their heating efficiency 5. Sub-lethal magnetic hyperthermia: cellular response to mild heat stress 6. Current status of in vivo application of magnetic hyperthermia for cancer treatment

Part 3. Optical hyperthermia 1. Principles of optical hyperthermia (J. C. Bischof) 2. Gold plasmonic nanoparticles as photothermal therapy agents 3. Graphene based nanomaterials for optical hyperthermia applications 4. Novel nanomaterials for photothermal therapy 5. In vitro applications: mechanism of cell death induced by optical hyperthermia 6. Current status of in vivo photothermal therapy applications

Part 4. Synergistic modalities 1. Synergistic effect of dual magnetic/optical heating 2. Hybrid magnetic-plasmonic nanomaterials for bimodal hyperthermia 3. Smart multifunctional magnetic nanoparticles for combined drug delivery and magnetic hyperthermia

Authors

Raluca Maria Fratila Marie Sklodowska-Curie Researcher, Institute of Materials Science of Aragon (ICMA),University of Zaragoza, Spain. Dr Raluca M. Fratila (Petrosani - Romania) obtained her PhD in Chemistry from the University "Politehnica” Bucharest (Romania) in 2005. She accomplished postdoctoral stays at the University of Basque Country, San Sebastian, Spain (2006-2008), and the University of Twente, Enschede, The Netherlands (2009-2013). In November 2013, she became a Marie Curie COFUND-ARAID researcher at the Institute of Nanoscience of Aragón (INA), University of Zaragoza, Spain. In 2015 she moved to the Aragon Materials Science Institute (University of Zaragoza, Spain) as a Marie Sklodowska-Curie researcher and since 2017 she is a Ramón y Cajal tenure-track researcher at the University of Zaragoza. Her research interests include bioorganic and bioorthogonal chemistry, magnetic resonance imaging (MRI), magnetic hyperthermia and biofunctionalization of magnetic nanoparticles for biomedical applications. Jesús Martínez De La Fuente Principal investigator, Nanotechnology and Apoptosis Group and Permanent Researcher, Spanish Research Council, Institute of Materials Science of Aragon, Spain. Prof. Jesús Martínez de la Fuente is a Research Professor affiliated to the Institute of Nanoscience and Materials of Aragon, CSIC-University of Zaragoza and CIBER-BBN, in Spain. He created his own research group (BIONANOSURF Group) at the University of Zaragoza in 2007, becoming internationally recognized in nanomaterials and biofunctionalization. The multidisciplinary nature of the group facilitates research and development in numerous areas, including biosensors, gene therapy, magnetism, photochemistry, surface chemistry and molecular metal oxides, among others. Prof. Martínez de la Fuente has extensive experience in the synthesis and characterization of novel nanomaterials and their biofunctionalization for the use and development of the next generation of nanobiosensors and nanotherapeutics. In 2009, he founded the spin-off Nanoimmunotech SL. He has also been a pioneer in the application of gold nanoparticles in gene therapy and he has developed a methodology for the use of gold nanoparticles functionalized with carbohydrates (glyconanoparticles) for the study of biological processes (embryogenesis, cancer, inflammation, etc.). In 2010, he was awarded the Aragón Investiga "Young Researchers" prize, and in 2013, he was rewarded by the Shanghai Administration with the 1000 Talent Plan program to be a Visiting Professor at the Jiao Tong University of Shanghai. Since 2014, he is a permanent researcher at the Institute of Nanoscience and Materials of Aragon-CSIC and member of CIBER-BBN.