A complete case study with all coding sequences from the bacteria Borrellia burgdorferi illustrates how multivariate analyses reveals evolutionary mechanisms acting at the molecular level. They are either mutationnal (symmetric and asymmetric directionnal mutation pressure) or selective (selection against head-on collisions or linked to gene expressivity or subcellular location).
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1. Introduction to correspondence analysis 2. Global codon usage 3. Synonymous codon usage 4. Non-synonymous codon usage 5. Within and between-group variability decomposition
Dr. Jean R. Lobry is a professor-researcher at Claude University Bernard Lyon as university lecturer since 1992 and then as a university professor in 2006