Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource.
The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike.
- Provides comprehensive coverage on diagnosis, therapy, pharmacotherapy and disease prevention in context of the microbiome and metabolome
- Focuses on the proposed physiological or pathological conditions
- Presents an up-to-date, useful reference
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Block I Tools, Toolstations and Models 1. Germ-Free Animals as a Tool to Study Indigenous Microbiota 2. Germ-Free Mouse Technology in Cardiovascular Research 3. The Gut Microbiome Beyond the BacteriomedThe Neglected Role of Virome and Mycobiome in Health and Disease 4. Techniques for Phenotyping the Gut Microbiota Metabolome 5. Metabolomics Tools and Information Retrieval in Microbiome Hacking 6. Laboratory Simulators of the Colon Microbiome 7. Potential of Metabolomics to Breath Tests
Block II Background Information 8. Metabolome and Microbiome From Infancy to Elderly 9. The Oral Microbiome 10. The Gastric Microbiome in Benign and Malignant Diseases 11. The Human Vaginal Microbiome 12. Bioactive Molecules of the Human Microbiome: Skin, Respiratory Tract, Intestine 13. Role of the Microbiome in Intestinal Barrier Function and Immune Defense 14. The Cross Talk Between Bile Acids and Intestinal Microbiota: Focus on Metabolic Diseases and Bariatric Surgery
Block III Established and Experimental Interventions 15. Use of Probiotics in Inflammatory Bowel Disease 16. Current Status of Fecal Microbiota Transplantation 17. Effects of Probiotics on Improvement of Metabolic Factors in Pregnant Women: A Metaanalysis of Randomized Placebo-Controlled Trials 18. Current Options for Fecal Transplantation in Clostridium difficile Infection 19. Targeted Delivery of Bacteriophages to the Gastrointestinal Tract and Their Controlled Release: Unleashing the Therapeutic Potential of Phage Therapy 20. The Unknown Effect of AntibioticInduced Dysbiosis on the Gut Microbiota 21. The Myth and Therapeutic Potentials of Postbiotics
Block IV Diagnostic and Therapeutical Applications 22. The Microbiome and Metabolome in Metabolic Syndrome 23. The Gut Microbiota as a Therapeutic Approach for Obesity 24. The Gut Microbiome After Bariatric Surgery 25. Gut Dysbiosis in Arterial Hypertension: A Candidate Therapeutic Target for Blood Pressure Management 26. The Emerging Role of MicrobiomeeGuteBrain Axis in Functional Gastrointestinal Disorders 27. The Microbiome and Metabolome in Nonalcoholic Fatty Liver Disease 28. The Microbiome and Metabolome in Alcoholic Liver Disease 29. The Microbiome, Metabolome, and Proteome in Preterm Neonatal Sepsis 30. Gut Microbiome in the Elderly Hospitalized Patient: A Marker of Disease and Prognosis? 31. The Lung Microbiome, Metabolome, and Breath Volatolome in the Diagnosis of Pulmonary Disease
Joel Faintuch is a gastrointestinal surgeon, and former International Guest Fellow of the American College of Surgeons. He is Honorary Fellow of three Surgical Societies, and has served as Visiting Professor at the University of Maastricht. He was the pioneer of Parenteral and Enteral Nutrition in Brazil and South America, and a founding member of three medical societies. In the last years, his focus has been in the Intestinal Microbiome. Joel Faintuch is the author of over 250 articles in peer-reviewed journals, along with 10 books, three theses, and over 200 chapters in books, and other publications.
Salomao Faintuch is the Clinical Director of Vascular and Interventional Radiology at Beth Israel Deaconess Medical Center and Harvard Medical School. He has authored more than 50 articles in peer-reviewed journals, along with 5 Society Guidelines and Standards of Practice and 3 textbooks. He is a Radiological Society of North America Research Scholar, serves in eight national society committees, and is member of the Editorial Board of three international journals.