The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provide significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research.
- Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications
- Includes the work of world-renowned editors
- Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Biology Section 2. Taxonomy/Phylogeny
Appearance/Morphology/Anatomy & Development/Physiology (Morphophysiology) General appearance/morphology 3. Head and Body 4. Integumentary System 5. Respiratory System 6. Skeletal System 7. Muscular System
Tissues and Organs Associated with Special Senses 8. Vision 9. Mechanosensory Lateral line System 10. Chemoreception 11. Hearing and Vestibular Function
Anatomy and Embryo Development 12. Head and Body 13. Digestive System 14. Cardiovascular System 15. Urinary System 16. Reproductive Systems 17. Endocrine Systems 18. Nervous Systems 19. Physiology, hematology, and clinical chemistry, gas exchange, hormonal regulation, regulatory osmolality 20. Immunology 21. Pigment/Chromophores 22. Sexual characteristics 23. Geographic Range/Natural Distribution 24. Natural History/Ecological Niche 25. Behavior of Wild Populations 26. Genetics
Husbandry Section 27. Introduction to Husbandry 28. Aquatics Facilities Design 29. Housing Types 30. Water Quality: definitions, effects on health, testing, normal values, equipment used, records 31. Filtration: definitions, testing methods, normal values, equipment used, records 32. Systems Maintenance and Troubleshooting: methods, equipment used, records 33. Cleaning and Disinfection of Life Systems: methods, equipment used, records 34. Feeding/Nutrition 35. Breeding/Colony Management 36. Larviculture 37. Importation and Quarantine 38. Exportation and Transport 39. Analgesia, Anesthesia, and Euthanasia 40. Regulatory Oversight, USA and internationally 41. Health Surveillance Programs
Diseases Section 42. Idiopathic and Water Quality Related Diseases 43. Parasitic Diseases: Including Microsporidia 44. Bacterial Diseases: Including Saprolegnia 45. Viral Diseases 46. Neoplasms (naturally occurring, associations with other diseases) 47. Special procedures (for disease diagnosis and treatment)
Research Section 48. Zebrafish as a Model to Understand Vertebrate Development 49. Zebrafish as a Model to Understand Neural Circuitry and Behavior 50. Zebrafish as a Model to Understand Human Genetic Diseases 51. Zebrafish as a Model to Understand Host-Microbe Interactions and Host-Pathogen Interactions 52. Zebrafish as a Platform for Technology Development 53. Zebrafish as a Platform for Genetic Screening 54. Zebrafish as a Platform for Toxicology and Drug Screening (or split into two)
Samuel Cartner, D.V. M., Ph.D., is the Assistant Vice President for Animal Research Services and Director of the Animal Resources Program (ARP) at the University of Alabama at Birmingham (UAB). He received his DVM from Auburn College of Veterinary Medicine and PhD from UAB. Dr. Cartner has served in multiple roles with organizations that promote premium laboratory animal care. Dr. Cartner is a faculty member in the Department of Genetics. His research interest includes genetic susceptibility to infectious disease, and the development of animal models of human and animal disease. Recently Dr. Cartner has focused on investigations that lead to improvements of laboratory animal care and use.
Eisen, Judith S.
Judith S. Eisen, Ph.D., earned her Doctorate at Brandeis University. She is a professor at the University of Oregon and a member of the Institute of Neuroscience at Oregon. The focus of Eisen's research is to understand the mechanisms underlying development and function of the vertebrate nervous system. Eisen uses zebrafish in her research.
Farmer, Susan F.
Susan C. Farmer, DVM, Ph.D., is the Senior Clinical Veterinarian and Co-Director of the Zebrafish Research Facility at the University of Alabama. Services offered by the facility are husbandry, larviculture, cryopreservation and research support. Dr. Farmer have her DVM degree from Mississippi State University and her Ph.D. in Pathology/Experimental Pathology from the University of Alabama at Birmingham.
Guillemin, Karen J.
Karen Guillemin, Ph.D., earned her Doctorate at Stanford University. She is a Professor at the University of Oregon and a member of the Institute of Molecular Biology at Oregon. Dr. Guillemin studies host-microbe interactions in development and disease, and uses zebrafish in her research.
Kent, Michael L.
Michael Kent, Ph.D., is a Professor of Microbiology at Oregon State University in the College of Veterinary Medicine. Kent's lab focuses on two major research areas: diseases of zebrafish in research facilities and impacts of pathogens on wild salmonid fishes. Dr. Kent is also a co-PI at the Zebrafish International Resource Center where he assists with health studies and their diagnostic service.
Sanders, George Lawrence
George E. Sanders D.V.M., M.S. earned his Doctorate in Veterinary Medicine from Louisiana State University's School of Veterinary Medicine. He received his Masters of Science in Comparative Medicine at the University of Washington. Dr Sanders is a Lecturer and is the Director of the Aquatic Animal Program, which provides multiple resources, training, instruction, and coordinates veterinary care for aquatic research animals at the University of Washington.