The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research.
- Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications
- Includes the work of world-renowned authors
- Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
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1. History of Zebrafish Research
3. Zebrafish Genetics
4. Geographic Range and Natural Distribution
5. Behavior of Wild Populations
Appearance, Development, Anatomy, Physiology
6. Zebrafish in Biomedical Research: Head and Body: Anatomy
7. Establishing the Body Plan: The First 24 Hours of Zebrafish Development
Organ Systems: Development, Anatomy, Physiology
8. Zebrafish Integumentary System
9. Zebrafish Pigmentation
10. Respiratory System
11. Skeletal System Morphophysiology
12. Zebrafish Myology
13. It Takes Guts: Development of the Embryonic and Juvenile Zebrafish Digestive System
14. The Zebrafish Cardiovascular System
15. Development of the Zebrafish Pronephric and Mesonephric Kidneys
16. Reproductive System
17. Endocrine Systems
18. Nervous Systems
20. Physiology: Hematology and Clinical Chemistry, Gas Exchange, and Regulatory Osmolality
Tissues and Organs Associated with Special Senses
21. Zebrafish in Biomedical Research: The Retina and Vision
22. The Mechanosensory Lateral Line System
23. Inner Ear and Hearing
24. Introduction to Zebrafish Husbandry
25. Aquatic Facility Design Considerations: Incorporating Aquatics into an Animal Facility
26. Aquatic Housing
27. Cleaning and Disinfection of Life Systems
28. Zebrafish Aquatic Systems: Preventative Maintenance and Troubleshooting
29. Water Quality for Zebrafish Cultura
30. Recirculating Aquaculture Systems (RAS) for Zebrafish Culture
31. Zebrafish Breeding and Colony Management
32. Zebrafish Larviculture
33. Zebrafish Nutrition--Moving Forward
34. Anesthesia, Analgesia, and Euthanasia of the Laboratory Zebrafish
35. Health Xurveillance Programs
36. Importation and Quarantine
37. Export and Transportation of Zebrafish
38. Regulations, Policies and Guidelines Pertaining to the Use of Zebrafish in Biomedical Research
39. Water Quality and Idiopathic Diseases of Laboratory Zebrafish
40. Important Parasites of Zebrafish in Research Facilities
41. Bacterial and Fungal Diseases of Zebrafish
42. Viral Diseases
43. Nonexperimentally Induced Neoplastic and Proliferative Lesions in Laboratory Zebrafish
44. Special Procedures for Zebrafish Diagnostics
45. Zebrafish as a Model to Understand Vertebrate Development
46. Zebrafish as a Model for Revealing the Neuronal Basis of Behavior
47. Zebrafish as a Model to Understand Human Genetic Diseases
48. Zebrafiish as a Model for Investigating
49. Targeted Editing of Zebrafish Genes to Understand Gene Function and Human Disease Pathology
50. Zebrafish as a Platform for Genetic Screening
51. Zebrafish as a Platform for Drug Screening
Samuel Cartner, D.V. M., Ph.D., is the Assistant Vice President for Animal Research Services and Director of the Animal Resources Program (ARP) at the University of Alabama at Birmingham (UAB). He received his DVM from Auburn College of Veterinary Medicine and PhD from UAB. Dr. Cartner has served in multiple roles with organizations that promote premium laboratory animal care. Dr. Cartner is a faculty member in the Department of Genetics. His research interest includes genetic susceptibility to infectious disease, and the development of animal models of human and animal disease. Recently Dr. Cartner has focused on investigations that lead to improvements of laboratory animal care and use.
Eisen, Judith S.
Judith S. Eisen, Ph.D., earned her Doctorate at Brandeis University. She is a professor at the University of Oregon and a member of the Institute of Neuroscience at Oregon. The focus of Eisen's research is to understand the mechanisms underlying development and function of the vertebrate nervous system. Eisen uses zebrafish in her research.
Farmer, Susan F.
Susan C. Farmer, DVM, Ph.D., is the Senior Clinical Veterinarian and Co-Director of the Zebrafish Research Facility at the University of Alabama. Services offered by the facility are husbandry, larviculture, cryopreservation and research support. Dr. Farmer have her DVM degree from Mississippi State University and her Ph.D. in Pathology/Experimental Pathology from the University of Alabama at Birmingham.
Guillemin, Karen J.
Karen Guillemin, Ph.D., earned her Doctorate at Stanford University. She is a Professor at the University of Oregon and a member of the Institute of Molecular Biology at Oregon. Dr. Guillemin studies host-microbe interactions in development and disease, and uses zebrafish in her research.
Kent, Michael L.
Michael Kent, Ph.D., is a Professor of Microbiology at Oregon State University in the College of Veterinary Medicine. Kent's lab focuses on two major research areas: diseases of zebrafish in research facilities and impacts of pathogens on wild salmonid fishes. Dr. Kent is also a co-PI at the Zebrafish International Resource Center where he assists with health studies and their diagnostic service.
Sanders, George E.
George E. Sanders, DVM, M.S., is certified as a Fish Pathologist by the American Fisheries Society Fish Health Section, a Senior Lecturer, and the Aquatic Animal Program Director for the Department of Comparative Medicine at the University of Washington. He provides multiple resources, program development, facility and systems design, training, instruction, regulatory compliance, and coordinates veterinary care and pathology for all aquatic research animals. Dr. Sanders received his DVM from Louisiana State University School of Veterinary Medicine and his Masters of Science in Comparative Medicine from the Department of Comparative Medicine at the University of Washington.