Basic Biostatistics for Medical and Biomedical Practitioners, Second Edition makes it easier to plan experiments, with an emphasis on sample size. It also shows what choices are available when simple tests are unsuitable and offers investigators an overview of how the kinds of complex tests that they won't do on their own work. The second edition presents a new, revised and enhanced version of the chapters, taking into consideration new developments and tools available, discussing topics, such as the basic aspects of statistics, continuous distributions, hypothesis testing, discrete distributions, probability in epidemiology and medical diagnosis, comparing means, regression and correlation.
This book is a valuable source for students and researchers looking to expand or refresh their understanding of statistics as it applies to the biomedical and research fields. Based on the author's 40+ years of teaching statistics to medical fellows and biomedical researchers across a wide range of fields, it is a valuable source for researchers who need to understand more about biostatistics to apply it to their work.
- Introduces procedures, such as multiple regression, Poisson distribution, binomial and multinomial distributions, variance analysis, and how to design and sample clinical trials
- Presents a new section on ANCOVA
- Gives references to free online tests
- Includes over 200 diagrams, enabling the reader to visualize the results
- Discusses NHST testing in detail, its disadvantages, and how to think about probability
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Basic Aspects of Statistics 1. Basic Concepts 2. Statistical Use and Misuse in Scientific Publications 3. Some Practical Aspects 4. Exploratory Descriptive Analysis 5. Basic Probability
Continuous Distributions 6. Normal Distribution 7. Statistical Inference: Confidence Limits and the Central Limit Theorem 8. Other Continuous Distributions 9. Outliers and Extreme Values
Hypothesis Testing 10. Hypothesis Testing: The Null Hypothesis, Significance and Type I Error 11. Hypothesis Testing: Sample Size, Effect Size, Power, and Type II Errors
Discrete Distributions 12. Permutations and Combinations; Logarithms 13. Hypergeometric Distribution 14. Categorical and Cross-Classified Data: Goodness of Fit and Association 15. Categorical and Cross-Classified Data 16. Binomial and Multinomial Distributions 17. Proportions 18. The Poisson Distribution 19. Negative Binomial Distribution
Probability in Epidemiology and Medical Diagnosis 20. Some Epidemiological Considerations: Odds Ratio, Relative Risk, and Attributable Risk 21. Probability, Bayes Theorem, Medical Diagnostic Evaluation, and Screening
Comparing Means 22. Comparison of Two Groups: T Tests and Non-Parametric Tests 23. T Test Variants: Cross-Over Tests, Equivalence Tests 24. Multiple Comparisons 25. Analysis of Variance. I
One-Way 26. Analysis of Variance. II
More Complex Forms
Regression and Correlation 27. Linear Regression 28. Variations Based on Linear Regression 29. Correlation 30. Multiple Regression 31. Serial Measurements: Time Series, Control Charts, Cusums 32. Dose-Response Analysis 33. Logistic Regression 34. Poisson Regression
Miscellaneous Topics 35. Survival Analysis 36. Meta-analysis 37. Resampling Statistics 38. Design: Sampling, Clinical Trials
Julien I E Hoffman, M.D., F.R.C.P (London) was born and educated in Salisbury (now Harare) in Southern Rhodesia (now Zimbabwe). He received a Bsc (Hons) in 1945 from the University of the Witwatersrand in South Africa, and his M.B., B.Ch. degree there in 1949. After working in the Departments of Medicine in Johannesburg General Hospital and in the Central Middlesex Hospital in London, he worked for the Medical Research Council at the Royal Postgraduate School in Hammersmith, London. Then he spent two years training in Pediatric Cardiogy at Boston Children's Hospital, followed by 15 months as a Fellow at the Cardiovascular Research Institute (CVRI) at the University of California in San Francisco (UCSF).
In 1962 he joined the faculty of the Albert Einstein College of Medicine in New York, and moved in 1966 to UCSF as Associate Professor of Pediatrics and member of the CVRI. He spent 50% of his time in the care of children with heart disease and 50% of his time doing research into the pathophysiology of the coronary circulation.
His interest in Statistics began while taking his Science degree. In England, he took a short course run by Bradford Hill. On returning to Johannesburg he was assigned to statistical analyses for other members of the Department of Medicine. Learning was by trial and error, helped by Dr J Kerrich, head of the University's Statistics Department. Hoffman began teaching statistics to Medical students in 1964, and in San Francisco conducted an approved course for Fellows and Residents for over 30 years. He was a member of the Biostatistics group for approving and coordinating statistics at UCSF. For many years he was a statistical consultant for the journal Circulation Research, and was intermittently statistical consultant to several other medical journals.