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Diagnostic Pathology: Kidney Diseases. Edition No. 3

  • ID: 4700393
  • Book
  • April 2019
  • 1176 Pages
  • Elsevier Health Science

Comprehensive and up to date, the third edition of Diagnostic Pathology: Kidney Diseases, written by Robert B. Colvin, MD and Anthony Chang, MD, expertly covers all aspects of common and rare renal diseases and their variants. This easy-to-use, point-of-care reference offers a state-of-the-art, concise presentation of major pathological, clinical, pathophysiological, and genetic information for more than 240 diagnoses, making it an ideal resource for pathologists and nephrologists to improve knowledge and skills. Significantly revised information throughout ensures that you remain current with everything new regarding the pathology and pathogenesis of nonneoplastic kidney diseases.

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Introduction and Overview

Introduction to Renal Pathology

Normal Kidney Structure

Normal Kidney Development

Glomerular Diseases


Minimal Change Disease

Classification of FSGS

Etiologic Classification of FSGS

FSGS, Primary

FSGS, Adaptive (Secondary)

Collapsing Glomerulopathy

Membranous Glomerulonephritis

Etiologic Classification of Membranous Glomerulonephritis

Membranous Glomerulonephritis, Primary

Membranous Glomerulonephritis, Secondary

Membranous Glomerulonephritis With Anti-TBM Antibodies

C3-Related Glomerulonephritis and Membranoproliferative Glomerulonephritis

Classification of MPGN and Complement-Related Diseases

Dense Deposit Disease

C3 Glomerulonephritis

Membranoproliferative Glomerulonephritis With Immune Complexes

IgA-Related Glomerulonephritis

Overview of IgA-Related Glomerulopathies

IgA Nephropathy

IgA Vasculitis (Henoch-Schönlein Purpura)

SLE and Related Autoantibody-Mediated GN

Systemic Lupus Erythematosus

Mixed Connective Tissue Disease

Rheumatoid Arthritis

Mixed Cryoglobulinemic Glomerulonephritis

Idiopathic Nonlupus Full-House Nephropathy

Anti-GBM Nephritis

Anti-GBM Glomerulonephritis

Atypical Anti-GBM Nephritis

Monoclonal Immunoglobulin Diseases

Introduction to Diseases With Monoclonal Immunoglobulin Deposits

Monoclonal Immunoglobulin Deposition Disease

Proliferative Glomerulonephritis With Monoclonal IgG Deposits

Membranous Glomerulonephritis With Masked IgG ? Deposits

Type I Cryoglobulinemic Glomerulonephritis

Waldenström Macroglobulinemia


Amyloidosis Classification

AL/AH Amyloidosis

AA Amyloidosis

AFib Amyloidosis

AGel Amyloidosis

ALECT2 Amyloidosis

AApoAI Amyloidosis

ApoAII Amyloidosis

AApoAIV Amyloidosis

AApoCII Amyloidosis

ATTR Amyloidosis

Idiopathic Fibrillary Glomerulopathies

Diseases With Organized Deposits

Fibrillary Glomerulopathy

Immunotactoid Glomerulopathy

Fibronectin Glomerulopathy

Diabetic Renal Disease

Diabetic Nephropathy

Idiopathic Nodular Glomerulopathy

Infection-Related Glomerular Disease

Overview of Infection-Related Glomerular Disease

Acute Poststreptococcal Glomerulonephritis

Acute Postinfectious Glomerulonephritis, Nonstreptococcal

IgA Acute Glomerulonephritis Associated With *Staphylococcus aureus*

Glomerulonephritis of Chronic Infection, Including Shunt Nephritis



Lyme Disease

Hepatitis B Virus

Hepatitis C Virus

HIV-Associated Nephropathy

Miscellaneous HIV-Associated Renal Diseases




Drug Induced Glomerular Diseases

Drug-Induced Minimal Change Disease

Bisphosphonate-Induced Collapsing Glomerulopathy

Chloroquine Toxicity

Anti-Hepatitis C Virus Drugs

Anti-EGFR Drugs

Genetic Diseases of the Glomerulus

Overview and Classification of Genetic Diseases of the Glomerulus

Genetic Diseases of the Glomerular Basement Membrane Collagen

Alport Syndrome

Thin Basement Membrane Disease

Genetic Diseases of the Podocyte

Diffuse Mesangial Sclerosis

Congenital Nephrotic Syndrome of the Finnish Type

Pierson Syndrome

Galloway-Mowat Syndrome

Denys-Drash Syndrome

Frasier Syndrome

Podocin Deficiency

Alpha-Actinin-4 Deficiency

Autosomal Dominant FSGS Due to *INF2* Mutations

*APOL1*-Related Glomerular Disease

Schimke Immuno-Osseous Dysplasia

Genetic Storage and Lipid Diseases

Lecithin-Cholesterol Acyltransferase Deficiency

APOE Lipoprotein Glomerulopathy

Type III Hyperlipoproteinemia

Fabry Disease

Gaucher Glomerulopathy

I-Cell Disease (Mucolipidosis II)

Alagille Syndrome

Other Genetic Diseases Affecting the Glomerulus

Glomerulopathy of Hereditary Multiple Exostoses

Type III Collagen Glomerulopathy

Nail-Patella Syndrome

Miscellaneous Glomerular Diseases

C1q Nephropathy

IgM Nephropathy

Cryofibrinogenic Glomerulopathy

Hepatic Glomerulosclerosis and IgA Deposition

Hemophagocytic Glomerulopathy

Podocyte Infolding Glomerulopathy

Metabolic Syndrome/Obesity-Related Glomerular Disease

Intravascular Large B-Cell Lymphoma

Vascular Diseases

Overview and Classification of Systemic Vasculitides

ANCA Disease

ANCA-Related Glomerulonephritis

Microscopic Polyangiitis

Granulomatosis With Polyangiitis

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

Drug-Induced ANCA Vasculitis

Non-ANCA Vasculitides

Polyarteritis Nodosa

Kawasaki Disease

Giant Cell Arteritis

Takayasu Arteritis

Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)

Thrombotic Microangiopathies

Introduction to Thrombotic Microangiopathies

Hemolytic Uremic Syndrome, Infection Related

Thrombotic Microangiopathy, Genetic

Thrombotic Microangiopathy, Autoimmune

Thrombotic Microangiopathy, Drug Induced

Postpartum Hemolytic Uremic Syndrome

Scleroderma Renal Disease

Multicentric Castleman Disease

Other Diseases Affecting the Endothelium

Preeclampsia, Eclampsia, HELLP Syndrome

Radiation Nephropathy

Glomerulopathy of Hereditary Multiple Extoses

Sickle Cell Nephropathy

Hypertensive Renal Disease

Hypertensive Renovascular Disease

Renal Artery Stenosis

Fibromuscular Dysplasia


Thrombotic and Embolic Disease

Renal Vein Thrombosis

Renal Artery Thrombosis

Atheromatous Emboli

Hydrophilic Polymer Emboli

Tubulointerstitial Diseases

Overview and Classification of Tubulointerstitial Diseases

Differential Diagnosis of Acute Interstitial Nephritis

Ischemic Injury

Acute Tubular Injury

Renal Cortical Necrosis


Bile Cast Nephropathy

Immunologic Tubular Disease

Tubulointerstitial Nephritis With Uveitis

Sjögren Syndrome

IgG4-Related Kidney Disease

Idiopathic Hypocomplementemic Tubulointerstitial Nephritis

Anti-Tubular Basement Membrane Disease

Antibrush Border Autoantibody Tubulointerstitial Nephritis


Tubulointerstiital Nephritis with IgM+ Plasma Cells

Giant Cell Tubulitis With TBM Deposits

Monoclonal Immunoglobulin Diseases of Tubules

Light Chain Cast Nephropathy

Light Chain Proximal Tubulopathy With Crystals

Light Chain Proximal Tubulopathy Without Crystals

Drug-Induced Tubulointerstitial Diseases

Drug-Induced Acute Interstitial Nephritis

Drugs That Cause Tubulointerstitial Nephritis

Checkpoint Inhibitor-Induced Kidney Diseases

Papillary Necrosis


Cisplatin Nephrotoxicity

Osmotic Tubulopathy

Antiviral Drug Nephrotoxicity

Acute Phosphate Nephropathy

Lithium-Induced Renal Disease

Calcineurin Inhibitor Toxicity

mTOR Inhibitor Toxicity

Vancomycin-Induced Cast Nephropathy

Warfarin Nephropathy

Illicit Drugs and Opioids

Toxic Injury

Lead and Other Heavy Metal Toxins

Aristolochic Acid Nephropathy

Balkan Endemic Nephropathy

Ethylene Glycol Toxicity


Autosomal Dominant Tubulointerstitial Kidney Disease

Autosomal Dominant Tubulointerstitial Kidney Disease, *MUC1*-Related

Autosomal Dominant Tubulointerstitial Kidney Disease, *UMOD*-Related

Autosomal Dominant Tubulointerstitial Kidney Disease, *REN*-Related

Autosomal Dominant Tubulointerstitial Kidney Disease, *HNF1B*-Related

Genetic Crystal Depostion Diseases

Primary Hyperoxaluria



Uric Acid Nephropathy/Gout

Genetic Transport Diseases

Bartter Syndrome

Dent Disease

Oculocerebrorenal Syndrome of Lowe

Other Genetic Diseases Affecting Tubules

Methylmalonic Acidemia

Systemic Karyomegaly


Miscellaneous Tubulointerstitial Diseases


Secondary Oxalosis

Mesoamerican Nephropathy

Extramedullary Hematopoiesis

Infections of the Kidney

Bacterial Infections of the Kidney

Acute Pyelonephritis

Chronic Pyelonephritis

Xanthogranulomatous Pyelonephritis



BCG Granulomatous Interstitial Nephritis


Megalocytic Interstitial Nephritis



Whipple Disease

Fungal, Rickettsial, and Parasitic Infections of the Kidney










Rickettsial Infections



Viral Infections of the Kidney

Polyomavirus Nephritis

Cytomegalovirus Infection

Adenovirus Infection

Epstein-Barr Virus Nephritis

Herpes Simplex Acute Nephritis

Hantavirus Nephropathy

Developmental Diseases

Overview of Congenital Anomalies of the Kidney and Urinary Tract



Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney

Ask-Upmark Kidney

Renal Tubular Dysgenesis

Cystic Diseases

Overview of Cystic Diseases


Autosomal Dominant Polycystic Kidney Disease

Autosomal Recessive Polycystic Kidney Disease

Nephronophthisis and Related Ciliopathies

Other Genetic Cystic Diseases

von Hippel-Lindau Disease

Tuberous Sclerosis Complex

Zellweger Syndrome

Miscellaneous Cystic Diseases

Medullary Sponge Kidney

Mixed Epithelial and Stromal Tumor Family

Pediatric Cystic Nephroma

Acquired Cystic Disease

Simple and Miscellaneous Cysts

Renal Lymphangioma/Lymphangiectasia

Diseases of the Collecting System

Introduction to Impediments to Urine Flow

Reflux Nephropathy

Obstructive Nephropathy


Loin Pain Hematuria Syndrome

Diseases of the Renal Allograft

Pathologic Classification of Renal Allograft Diseases


Evaluation of Allograft Kidney

Evaluation of the Donor Kidney


Acute T-Cell-Mediated Rejection

Chronic T-Cell-Mediated Rejection

Hyperacute Rejection

Acute Antibody-Mediated Rejection

Chronic Antibody-Mediated Rejection

Transcript Analysis of Renal Transplant Biopsies

Recurrent and De Novo Diseases

Diseases That Recur in Allografts

De Novo FSGS

De Novo Membranous Glomerulonephritis

Anti-GBM Disease in Alport Syndrome

Engraftment Syndrome

Nonimmunologic Injury

Acute Allograft Ischemia

Hyperperfusion Injury

Urine Leak


Transplant Renal Artery Stenosis

Renal Artery or Vein Thrombosis

Posttransplant Lymphoproliferative Disease

BK Polyomavirus Neoplasia

Stable and Accepted Grafts

Protocol Biopsies



Kidney Pathology in Recipients of Other Transplants

Kidney Diseases in Nonrenal Transplant Recipients

Graft-vs.-Host Glomerulopathies


Biopsy Reports

Kidney Needle Biopsy: Evaluation for Adequacy

Evaluation of Fibrosis

Immunofluorescence on Paraffin Tissue Sections

EM Processing From Paraffin or Frozen Tissue

Detection of PLA2R Deposits and Autoantibodies

Alport Collagen IV Immunofluorescence

C4d Immunohistochemistry/Immunofluorescence

Polyomavirus Detection in Tissue

Mass Spectrometry

Diagnostic Genetics of Kidney Diseases

Examination of the End-Stage Kidney

Examination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases

Evaluation of the Transplant Nephrectomy

Evaluation of Autopsy Kidneys

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Colvin, Robert B. Benjamin Castleman Distinguished Professor of Pathology, Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

Chang, Anthony Chief Intelligence and Innovation Officer (CIIO), Heart Failure Program, Children's Hospital of Orange County, CA, United States of America

Medical Director, Heart Failure Program, Children's Hospital of Orange County, CA, United States of America.

Anthony C. Chang MD, MBA, MPH, MS

After his cardiology training at the Children's Hospital of Philadelphia with his research interest in mathematics and chaos theory in biomedicine, Dr. Anthony Chang was an attending cardiologist in the cardiovascular intensive care unit of Boston Children's Hospital and an assistant professor at Harvard Medical School. Throughout his career as a pediatric cardiac intensive care physician, he has been interested in applications of biomedical data to decision-making. He completed his Masters of Science (MS) in Data Science with a sub-specialization in artificial intelligence from Stanford School of Medicine. He is also a computer scientist-in-residence at Chapman University. He is currently the Chief Intelligence and Innovation Officer and Medical Director of the Heart Failure Program at Children's Hospital of Orange County.

He is the founder and medical director of the Medical Intelligence and Innovation Institute (MI3) that is supported by the Sharon Disney Lund Foundation. The institute, founded in 2015, is dedicated to the introduction and implementation of artificial intelligence in medicine and was the first institute of its kind in a hospital. He intends to build a clinician-computer scientist interface with a nascent society (the Medical Intelligence Society) and is the editor-in-chief of Intelligence-based Medicine, the accompanying journal for his book, Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. He is the organizing chair for Artificial Intelligence in Medicine (AIMed) meetings around the world, the largest and most comprehensive clinician-led meetings that focus on applications of artificial intelligence in medicine and the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM). He is also the founding president of the Medical Intelligence Society (MIS).
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