The world of conjugated drugs (XDCs) is transforming cancer treatment, unlocking new levels of precision, conditional activation, and therapeutic potential. However, with rapid advancements, fierce competition, and an ever-expanding pipeline, staying ahead requires more than just insights - it demands up-to-date intelligence, strategic foresight, and data-driven decision-making.
In 2024/25 alone, the oncology pipeline saw a surge of innovation, with 436 new conjugated drugs, over 972 drugs with events, and 10,642 total events spanning 2,505 total drug programs - a clear signal of the accelerating pace and complexity in this space.
Introducing the Conjugated Drugs (XDCs) in Oncology Analytical Tool - your comprehensive solution to navigate this dynamic field, track emerging trends, and capitalize on groundbreaking opportunities.
The Ultimate Tool for Exploring What Makes This Field So Exciting
- XDCs represent a versatile and rapidly evolving class of cancer therapeutics, with at least seven distinct formats - Antibody-Drug Conjugates (ADCs), Peptide-Drug Conjugates (PDCs), Small Molecule-Drug Conjugates (SMDCs), Radioimmunoconjugates (RDCs), Oligonucleotide-Drug Conjugates (ODCs), Nanoparticle-Drug Conjugates, and Enzyme-Drug Conjugates - making this a highly dynamic space to watch as it reshapes the landscape of precision oncology.
- XDC payloads are among the most potent and diverse agents in oncology, including microtubule inhibitors, DNA-damaging agents, topoisomerase inhibitors, radioactive isotopes, immune- and gene modulators - each carefully selected and engineered to maximize tumor killing while minimizing systemic exposure, making payload innovation a critical driver of therapeutic impact and differentiation in the XDC space.
- Linker technology is the molecular lynchpin of XDC performance, enabling precise control over payload release through innovations like cleavable (pH-sensitive, enzyme-sensitive) and non-cleavable linkers. The choice of linker directly impacts stability, pharmacokinetics, and tumor selectivity, making it a strategic lever in optimizing safety, efficacy, and therapeutic index across XDC platforms.
- Conditional activation strategies add a powerful layer of precision to XDCs, enabling payload release specifically in the tumor microenvironment through triggers such as low pH, tumor-associated enzymes, hypoxia, or redox gradients. This tumor-selective activation enhances therapeutic index by minimizing off-target effects and represents a next-generation approach to smarter, safer drug delivery.
- The emergence of bi- and multispecific ADCs marks a new era in targeted therapy, enabling simultaneous engagement of multiple tumor antigens or immune effector pathways. This approach enhances tumor selectivity, overcomes antigen heterogeneity, and opens new opportunities for dual payload delivery or immune system modulation, making it a frontier of innovation in the XDC landscape.
The impact? A rapidly growing clinical pipeline, breakthrough FDA approvals, and a surge in investment opportunities - making the XDC field one of the most exciting frontiers in oncology today.
6 Game-Changing Benefits for You
With the Conjugated Drugs in Oncology Analytical Tool you will:
- Track the Competitive Landscape - monitor active organizations, new drugs, targets, and technologies
- Accelerate Licensing & Partnerships - access top biotech developers, BD&L contacts, and academic projects
- Power High-Impact Reports & Presentations - fuel data-driven decisions with near real-time market intelligence - all exportable in ready-made graphs and tables.
- Engage Key Opinion Leaders (KOLs) - connect with clinical and scientific experts shaping the field.
- Find the Right Investors - tap into a network of oncology-focused funding partners.
- Stay Ahead of Industry Events - analyze data from top global oncology conferences (AACR, ASCO, ESMO, ASH, and more)
Your Conjugated Drugs (XDCs) in Oncology Analytical Tool is never out of date thanks to continuous updates and monthly email alerts highlighting the latest developments in the field.
You will have thousands of drugs, targets, companies, clinical trials, deal,s and much more at your fingertips. See below for a breakdown of near-real-time coverage.
Support & Inspiration at Your Fingertips
Leverage expertise as your virtual business development team - ready when you are. The 24/7 support ensures help is always available, while the rich library of How-to Training Videos empowers you with proven best practices. From competitive pipeline analysis to real-world case studies submitted by fellow users, you’ll find actionable insights designed to elevate your work.
A Tool That Grows With You
Unlike static reports that offer just a snapshot in time, the Analytical Tools provide a full year of online access - complete with near real-time updates, new features, pipeline alerts, and dedicated support. When you’re ready to go further, you can seamlessly renew your access or upgrade to the industry-leading full-service platform: 1stOncology - your comprehensive partner in oncology drug development.
System Requirements
Web-based application compatible with all major browsers: Chrome, Firefox, Safari, and Internet Explorer
Internet access
Secure Your Access to Unrivaled Intelligence for Strategic Decision-Making in Oncology Drug Development
This tool is powered by an award-winning, artificial intelligence (AI) enhanced intelligence platform with over 25 years of expertise in oncology, delivering uniquely comprehensive business, competitive and clinical intelligence across all stages of oncology drug development.
For business development and search & evaluation, it provides unmatched visibility into the global oncology landscape - spanning technologies, targets, start-ups to pharma, and academic-commercial opportunities - making it a powerful deal book with integrated licensing contacts and thousands of past deals.
In clinical development, the tool features an industry-leading biomarker intelligence panel of over 3,000 biomarkers and tracks their roles as stratifying, predictive, and pharmacodynamic markers, alongside companion diagnostic initiatives from early stage to approval. Proprietary early success/failure indicators spotlight clinical leaders and laggards, helping you monitor and and anticipate shifts in the evolving landscape.
The clinical trial intelligence goes beyond endpoints, capturing dosage details, resistance mechanisms, adverse events, food effects, trial phase and status progression, first-in-human (FIH) studies, tumor stage/grade, and line of therapy (LoT) - offering a complete view of the trial landscape.
The publisher simplifies the complexity of combination therapy development, breaking down targets, drug modalities, indications, and trial stages to create a map of evolving strategies for fast, strategic decision-making.
Finally, the publisher integrates Real-World Evidence (RWE) with multi-point analytics tailored to any development stage. Whether segmented by drug modality, co-medication profiles, or biomarker clusters, the tool enables deep, contextual insights - driving faster, smarter, and evidence-based decisions in oncology research and development.
Coverage Breakdown from your Conjugated Drugs (XDCs) in the Oncology Analytical Tool
Competitor Overview
- Organizations Monitored: 1,200+
- Organization Types:
- Corporate: 1,061
- Private: 606
- Public: 352
- Academic: 114
- Startup: 115
- Cancer Ctr/Hospital: 40
- Big Pharma/Biotech: 36
Top 5 Drug Developers:
- Pfizer (incl Seagen)
- AstraZeneca
- AbbVie
- Immunomedics
- Hangzhou DAC Biotech
Top 5 Nations:
- USA
- China
- UK
- Canada
- South Korea
Pipeline
- Total No Drugs: 2,500+
- Discovery: 390+
- Preclinical: 1370+
- Phase 1: 370+
- Phase 2: 230+
- Phase 3: 83
- Pre-registration: 7
- Marketed: 33
- Target: 478
- Tumor Types: 215
- Clinical Trials: 2,426
- Clinical Biomarkers: 580
- Drugs in Combination Therapies: 241
Deals & Alliances
- No. Deals (Last 5 Years): 521
- BD&L Contacts: >2,400
- World-Wide Academic Commercial Opportunity Projects: 53
Funding & Investors
- Funding (Last 5 Years): >1,300
- Top Investors: 251
Companies Mentioned
- Pfizer (incl Seagen)
- AstraZeneca
- AbbVie
- Immunomedics
- Hangzhou DAC Biotech
