Advances in the science of immunology have improved the success rate of organ transplantations since the mid-twentieth century. Organ transplantation is now a lifesaving medical procedure for thousands of patients around the world with end-organ diseases. The lifesaving potential of transplantation has been limited by the number and quality of appropriate organ donors.
The evolution of brain death criteria by the Harvard Ad-Hoc Committee Report has opened the door to understanding the importance of medical, legal and ethical challenges of organ donation in support of the growth of the transplant science. The possibility of organ donation from living donors has enhanced organ availability for patients with kidney failure. Modern inotropes and immunosuppression regimens have been critical to the success of other organ transplant procedures. However, the cornerstone of successful transplantation continues to be the appropriate selection, evaluation, preservation of organ tissues and the successful surgical procurement process to mitigate the impact of tissue ischemia and reperfusion.
In this textbook, the art and science of organ donation and tissue preservation is examined. Through this authoritative text by leaders in the field, the editors provide a state of the art review of modern preservation techniques, patient selection, and screening criteria, as well as best practices for multi-organ procurement. Information presented in the book will familiarize readers with the initial steps of determining organ availability which ultimately enables health care professionals to realize the extraordinary potential of successful multi-organ transplant procedures. This guide is intended to be a fundamental resource for students, residents, faculty, and staff for all disciplines allied to health care delivery and organ donation.
Chapter 1 Introduction
Chapter 2 The Organ Allocation System
Chapter 3 Identification of the Brain Dead Donor
Chapter 4 Management of Public Health Service (Phs) Increased Risk Donors and Hepatitis C or HIV Infected Donors
Chapter 5 Management of the Multi-Organ Donor and Logistic Considerations
Chapter 6 Current State of Organ Preservation
Chapter 7 Organ Specific Considerations: Heart
Chapter 8 Organ Specific Considerations: Lung
Chapter 9 Liver Procurement: The Donor Hepatectomy
Chapter 10 Organ Specific Considerations: Pancreas and Kidney
Chapter 11 Living Donation
Chapter 12 Pediatric Issues: Split Liver/Living Liver Donation
Chapter 13 Islet Cell Donation
Chapter 14 The Future of Organ Donation: Ex-Vivo Preservation
Chapter 15 The Future of Organ Donation and Transplantation: 2018 and Beyond