Spontaneous Pathology of the Laboratory Nonhuman Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research.
Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors.
- Contains color illustrations that depict the most common lesions to augment descriptions
- Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP)
- Provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines
1. Introduction to 1st Edition 2. Choice of Primate species 3. Regulatory issues in the use of primates 4. Infectious Diseases 5. Clinical Examination 6. Salivary glands 7. Oral Cavity 8. Esophagus and Stomach 9. Small and Large Intestine 10. Liver 11. Exocrine Pancreas 12. Kidney 13. Urinary bladder, ureter, urethra 14. Brain 15. Spinal Cord and Nerves 16. Eye and associated glands 17. Skeletal Muscle 18. Bone and Joints 19. Skin and subcutis 20. Specialized sebaceous glands 21. Mammary Gland 22. Respiratory tract 23. Immune System 24. Bone Marrow 25. Female Reproductive Tract 26. Testis 27. Male sex glands 28. Heart 29. Blood Vessels 30. Thyroid 31. Parathyroid 32. Pituitary 33. Adrenal 34. Endocrine Pancreas 35. Hematology
Dr. Bradley has been with Charles River since 1998 where she is the director of pathology. In this capacity she leads a team of veterinary pathologists and pathology analysts. She has specialist interest and provides consultancy services in neuropathology, non-human primate pathology, medical devices, and cellular therapy products (human and animal stem cells). She is an experienced study pathologist for acute, long term reproductive toxicology, tumorigenicity, oncogenicity, microautoradiography, target animal safety and carcinogenicity studies. She has authored over 700 GLP or GMP compliant toxicological peer reviewed pathology and photomicroscopy reports. She is the GLP and GMP Study Director as well as the Quality Control Manager for GMP pathology services.
Dr. Chilton has been with Charles River since 2007 where she is the senior veterinary pathologist. She has specialist interest and provides consultancy services in neuropathology, non-human primate and comparative pathology. She has authored numerous GLP and investigative toxicological reports and is currently the neuropathology liaison to The National Chimpanzee Brain Resource (NCBR), George Washington University, Washington DC and staff pathologist for the Alamogordo Primate Facility, Alamogordo, NM.