Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.
- Emphasizes a comparative and multidisciplinary approach to the topic of sleep
- Covers the neurobiology and physiology of sleep stages, mechanisms of waking, and dreaming
- Discusses in detail the proposed functions of sleep, from health and rest, to memory consolidation and synaptic plasticity
- Examines the current state of research in mammalian and non-mammalian species, ranging from primates to invertebrates
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Theme A: Brain activity during sleep and waking 1. Neuronal activity during the sleep-wake cycle 2. Timing and topography of sleep onset: asynchronies and regional changes of brain activity 3. Local patterns of sleep and wakefulness 4. Hippocampal information processing and homeostatic regulation during REM and non-REM sleep
Theme B: Regulation of Waking and Sleeping 5. The circuit, cellular and synaptic bases of sleep-wake regulation 6. Hypocretin and the regulation of sleep-wake transitions 7. Serotonergic systems in sleep and waking 8. Adenosinergic control of sleep/wake behavior 9. NREM sleep regulation from neuronal assembly to ion 10. Neurobiological mechanism of non-REM sleep 11. The genetic regulation of human sleep-wake rhythms and patterns 12. Circadian and homeostatic regulation of sleep 13. The role of glia in sleep-wake regulation and function 14. Interactions between sleep and breathing 15. Neurobiological parallels, overlaps and divergences of sleep & anaesthesia
Theme C: REM Sleep and Dreaming 16. Neuroanatomical and neurochemical systems involved in REM sleep generation 17. Functions and circuits of REM sleep 18. Structural and functional differences in brain mechanisms of dream recall 19. Consciousness and meta-consciousness during sleep
Theme D: Evolution, Cross-Cultural and Comparative Approaches, and Novel Model Systems 20. Evolution of sleep and adaptive sleeplessness 21. Hunter-gatherer sleep and novel human sleep adaptations 22. Sleep in Drosophila 23. Sleep, immunity, and stress: novel insights from Drosophila 24. Sleep in fish models 25. Sleep in aquatic mammals 26. The role of sleep in song learning processes in songbird
Theme E: Sleep, Plasticity, and Memory 27. Sleep and brain development 28. Sleep and plasticity 29. Sleep-wake and cortical synaptic plasticity 30. Sleep stages and neural oscillations: A window into sleep's role in memory consolidation and cognitive abilities 31. Cued memory reactivation: A tool to manipulate memory consolidation during sleep 32. Sleep and memory consolidation: conceptual and methodological challenges
Theme F: Sleep, Emotion, and Motivation 33. The role of sleep in processing emotional information 34. Sleep and emotions: on sleep, emotional memories and depression 35. Motivational processes in the regulation of sleep/wake states
Theme G: Disturbed Sleep 36. The effects of sleep loss on brain functioning 37. Physiological and neurobehavioural consequences of chronic sleep restriction in rodent models 38. Imaging of the sleep disordered brain 39. Sleep impact on perception, memory, and emotion in adults and the effects of early life experience 40. Sleep and driving 41. Drug discovery and emerging treatments for sleep disorders 42. Insomnia pharmacotherapies: pharmacodynamics, strategies, new directions, and key measures in clinical trial investigations
Theme H: Sleep in Aging and Disease 43. Sleep and aging: circadian influences 44. Sleep, physical activity, and cognitive health in older adults 45. Sleep in normal aging, Alzheimer's disease and mild cognitive impairment 46. Sleep in major depression 47. Closing the loop between circadian rhythms, sleep and attention deficit hyperactivity disorder 48. Dissecting brain circuitry for sleep disorder narcolepsy in murine models 49. Rapid Eye Movement Sleep Behavior Disorder: Pathological neural circuits and association with Parkinson's Disease