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Open-Angle Glaucoma - Pipeline Insight, 2021

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    Clinical Trials

  • 80 Pages
  • May 2021
  • Region: Global
  • DelveInsight
  • ID: 4745393
This Open-angle glaucoma - Pipeline Insight, 2021 report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Open-angle glaucoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Open-angle glaucoma Understanding


Open-angle glaucoma: Overview


Glaucoma is an eye disease that gradually steals vision. Open-angle glaucoma is the most common type of glaucoma. Open-angle glaucoma is a chronic, progressive, and irreversible multifactorial optic neuropathy that is characterized by an open angle of the anterior chamber, optic nerve head changes, progressive loss of peripheral vision, followed by central visual field loss. Glaucoma affects 70 million people worldwide and is the second leading cause of blindness. The underlying pathology of Open-angle glaucoma lies in the apoptosis of retinal ganglion cells. Open-angle glaucoma can be clinically evaluated using a variety of diagnostic tools including optic disc changes, visual field changes, and elevated intraocular pressure. The goal of treatment of open-angle glaucoma is to prevent the progression of optic nerve head changes and also the prevention of deterioration of visual field.

Open-angle glaucoma - Pipeline Insight, 2021 report by the publisher outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Open-angle glaucoma pipeline landscape is provided which includes the disease overview and Open-angle glaucoma treatment guidelines. The assessment part of the report embraces, in depth Open-angle glaucoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Open-angle glaucoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights


The companies and academics are working to assess challenges and seek opportunities that could influence Open-angle glaucoma R&D. The therapies under development are focused on novel approaches to treat/improve Open-angle glaucoma.

Open-angle glaucoma Emerging Drugs Chapters


This segment of the Open-angle glaucoma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Open-angle glaucoma Emerging Drugs


QLS-101: Qlaris Bio

QLS-101 is a novel topical ocular therapy that lowers intraocular pressure. QLS-101 modulates KATP channel by relaxing vessels of the vascular and vascular-like tissues distal to the Trabecular Meshwork, thereby reducing distal outflow resistance and lowering Episcleral Venous Pressure (EVP). Qlaris Bio has initiated clinical studies with QLS-101 in patients with Primary Open Angle Glaucoma, Ocular Hypertension, Normal Tension Glaucoma, and Sturge-Weber syndrome.

Razuprotafib: Aerpio Pharmaceuticals

Razuprotafib is a novel small molecule Tie2 activator that enhances endothelial function and stabilizes blood vessels, including pulmonary and renal vasculature. Razuprotafib (AKB-9778) topical drops is currently under Phase II clinical evaluation for treatment of primary open angle glaucoma (POAG).

Open-angle glaucoma: Therapeutic Assessment


This segment of the report provides insights about the different Open-angle glaucoma drugs segregated based on following parameters that define the scope of the report, such as:


Major Players in Open-angle glaucoma


There are approx. 20+ key companies which are developing the therapies for Open-angle glaucoma. The companies which have their Open-angle glaucoma drug candidates in the most advanced stage, i.e. Phase III include, Ocular Therapeutix.

Phases


This report covers around 20+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Open-angle glaucoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Oral
  • Parenteral
  • Intravitreal
  • Subretinal
  • Topical
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type

The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Open-angle glaucoma: Pipeline Development Activities


The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Open-angle glaucoma therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities


The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Open-angle glaucoma drugs.

Open-angle glaucoma Report Insights

  • Open-angle glaucoma Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Open-angle glaucoma Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions Answered


Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Open-angle glaucoma drugs?
  • How many Open-angle glaucoma drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Open-angle glaucoma?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Open-angle glaucoma therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Open-angle glaucoma and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Qlaris Bio
  • Ocular Therapeutix
  • SALVAT
  • Aerpio Pharmaceuticals
  • Ocularis Pharma
  • PolyActiva
  • AbbVie
  • Annexon
  • Skye Bioscience
  • GrayBug
  • Quark Pharmaceuticals

Key Products

  • QLS-101
  • Travoprost ophthalmic
  • SVT18412
  • Razuprotafib
  • Phentolamine
  • PA5108
  • AGN 193408 sustained-release
  • ANX 007
  • NB 1111
  • GB 401
  • QPI-1017

Table of Contents

IntroductionExecutive Summary
Open-angle glaucoma: Overview
  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics
  • Comparative Analysis

Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Open-angle glaucoma - Analytical Perspective
In-depth Commercial Assessment
  • Open-angle glaucoma companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Open-angle glaucoma Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)
  • Comparative Analysis

Travoprost ophthalmic: Ocular Therapeutix
  • Product Description
  • Research and Development
  • Product Development Activities

Mid Stage Products (Phase II)
  • Comparative Analysis

QLS-101: Qlaris Bio
  • Product Description
  • Research and Development
  • Product Development Activities

Early Stage Products (Phase I/II)
  • Comparative Analysis

PA5108: PolyActiva
  • Product Description
  • Research and Development
  • Product Development Activities

Preclinical and Discovery Stage Products
  • Comparative Analysis

NB 1111: Skye Bioscience
  • Product Description
  • Research and Development
  • Product Development Activities

Inactive Products
  • Comparative Analysis

Open-angle glaucoma Key CompaniesOpen-angle glaucoma Key ProductsOpen-angle glaucoma- Unmet NeedsOpen-angle glaucoma- Market Drivers and BarriersOpen-angle glaucoma- Future Perspectives and ConclusionOpen-angle glaucoma Analyst ViewsOpen-angle glaucoma Key CompaniesAppendix
List of Tables
Table 1 Total Products for Open-angle glaucoma
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
List of Figures
Figure 1 Total Products for Open-angle glaucoma
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products

Companies Mentioned

A selection of companies mentioned in this report includes:

  • Qlaris Bio
  • Ocular Therapeutix
  • SALVAT
  • Aerpio Pharmaceuticals
  • Ocularis Pharma
  • PolyActiva
  • AbbVie
  • Annexon
  • Skye Bioscience
  • GrayBug
  • Quark Pharmaceuticals