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In Vitro Toxicity Testing: Technologies and Global Markets

  • ID: 4745512
  • Report
  • January 2019
  • Region: Global
  • 174 Pages
  • BCC Research
1 of 5

FEATURED COMPANIES

  • Abbott Laboratories, Inc.
  • Biovia
  • Drik Llc
  • Genedata
  • Insphero Ag
  • Perkinelmer, Inc.
  • MORE

Report Scope:

The scope of the report encompasses the major types of traditional toxicity testing that have been used, and the in vitro techniques that are being developed by industry, government agencies and nonprofits. It analyzes current market status, examines drivers on future markets and presents forecasts of growth over the next five years.

Technology developments, including the latest trends, are discussed. Other influential factors such as validation and testing strategies for pharmaceuticals, cosmetics, and chemicals also have been included.

Regulatory drivers play a large role in toxicology, determining the specific parameters of tests that have been explicitly required. They also heavily influence the testing that is performed by companies in earlier stages of research. The report examines the regulatory role and the different federal and international agencies that play an active role in vitro toxicology research, development and adoption.

The Report Includes:

  • 52 data table and 18 additional tables
  • An overview of the global markets and technologies for the in vitro toxicity testing techniques within the pharmaceutical industry
  • Analyses of global market trends with data from 2017, 2018, and projections of compound annual growth rates (CAGRs) through 2023
  • Information on the latest trends, technological developments and government regulations that influence the growth of the market
  • A breakdown of influential factors, such as the validation of alternative measures for toxicity and toxicity testing strategies for chemicals, pesticides, and food additives
  • Evaluation covering equipment, assays, cells, reagents, and services used in toxicity testing
  • Profiles of major players in the toxicology market, including Abbott Laboratories, Inc., Agilent Technologies, Inc., Evotec AG, GE Healthcare Life Sciences and Thermo Fisher Scientific, Inc.
Note: Product cover images may vary from those shown
2 of 5

FEATURED COMPANIES

  • Abbott Laboratories, Inc.
  • Biovia
  • Drik Llc
  • Genedata
  • Insphero Ag
  • Perkinelmer, Inc.
  • MORE

Chapter 1 Introduction

  • Study Goals and Objectives
  • Reasons for Doing This Study
  • Intended Audience
  • Scope of Report
  • Information Sources
  • Methodology
  • Geographic Breakdown
  • Analyst's Credentials
  • Custom Research
  • Related Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

  • Introduction
  • Regulatory Framework and Programs
  • European Union
  • India
  • Regulatory Programs
  • Key Market Growth Factors
  • Replacement of In Vivo Models, by In Vitro Models
  • In Vitro Toxicity in the Drug Discovery Process
  • CROs Gaining Popularity
  • Application of High-Throughput Screening in Toxicology
  • Opportunities
  • Extensive Funding, by Research Institutes on Toxicology
  • Paradigm Shift in Toxicity Testing in the 21st Century
  • Limitations and Challenges
  • Expensive Equipment Used in Toxicology

Chapter 4 Market Breakdown by Toxicity Endpoints and Tests

  • ADME
  • In Vitro Metabolism Offerings
  • Metabolism Reaction Phenotyping for Genetic Polymorphisms
  • Skin Irritation, Corrosion and Sensitization
  • Genotoxicity Testing
  • In Vitro Micronucleus Test (MNT)
  • Cytotoxicity Testing
  • Use of Cytotoxicity Assays for Acute Toxicity Testing
  • Example of Commercially Available Cytotoxicity Assay Kit
  • Ocular Toxicity
  • Organ Toxicity
  • Phototoxicity Testing
  • Dermal Toxicity
  • Carcinogenicity
  • The AMES Test
  • Neurotoxicity
  • Development and Reproductive Toxicity (DART)
  • Other Toxicity Endpoints and Tests

Chapter 5 Market Breakdown by End-User Industry

  • Pharmaceutical and Biotechnology Companies
  • Healthcare (Diagnosis)
  • Food and Beverage Industry
  • Chemical Industry
  • Challenges for Chemical Companies: Depth and Breadth
  • Personal Care Products (Cosmetics)
  • Contract Research Organizations
  • Research Institutes
  • Center for Alternatives to Animal Testing (CAAT)
  • European Union Reference Laboratory for Alternatives to Animal Testing (EURL)
  • The Hamner Institutes for Health Sciences

Chapter 6 Market Breakdown by Tool/Technology

  • Transcriptomics
  • Tools Used in Transcriptomics
  • Proteomics
  • Proteomics Tools
  • Metabolomics
  • Collaboration for Establishing Metabolomics Lab
  • Metabolomics Tools
  • Cellomics or Cytomics

Chapter 7 Market Breakdown by Component

  • Assays
  • Companies Strategies for the Development of New, and Expansion of Existing Products:
  • Assay Kits for High-Content Screening
  • Cell-Based Assays: Overview and Newer Developments
  • Components of Cell-Based Assay Systems
  • Equipment
  • Reagents and Kits
  • New Reagents in the Market
  • Software and Analytics
  • Trace Finder Software, by Thermo Fisher Scientific, Inc.
  • Services
  • ADME Screening

Chapter 8 Market Breakdown by Region

  • North America
  • United States
  • Recent Developments in the Region
  • Canada
  • Europe
  • United Kingdom
  • Germany
  • France
  • Spain
  • Italy
  • Rest of Europe
  • Asia-Pacific
  • China
  • Japan
  • India
  • Rest of Asia-Pacific
  • Rest of the World
  • Middle East
  • Africa
  • Latin America

Chapter 9 Patent Review/New Developments

  • Biomarkers for In Vitro Toxicology
  • Uses of In Vitro Biomarkers
  • In Vitro Biomarkers: Future Prospects
  • Types of Biomarkers
  • Competitive Landscape
  • Key Companies
  • Key Market Player Strategies
  • Patent Analysis

Chapter 10 Company Profiles

  • ABBOTT LABORATORIES, INC.
  • Business Overview
  • ACEA BIOSCIENCES, INC.
  • Business Overview
  • AGILENT TECHNOLOGIES, INC.
  • Business Overview
  • ALBANY MOLECULAR RESEARCH, INC.
  • Business Overview
  • APTUIT, INC.
  • Business Overview
  • BIOGNOSYS AG
  • Business Overview
  • BIORELIANCE
  • Business Overview
  • BIOVIA
  • CELLULAR DYNAMICS INTERNATIONAL, INC.
  • Business Overview
  • CHANTEST
  • Business Overview
  • CHARLES RIVER LABORATORIES
  • Business Overview
  • COVANCE, INC.
  • Business Overview
  • CYPROTEX PLC
  • Business Overview
  • DRIK LLC
  • Business Overview
  • ENZO LIFE SCIENCES, INC.
  • Business Overview
  • ESSEN BIOSCIENCE, INC.
  • Business Overview
  • EUROFINS SCIENTIFIC SE
  • Business Overview
  • Products Offered
  • EVOTEC AG
  • Business Overview
  • GE HEALTHCARE LIFE SCIENCES
  • Business Overview
  • GENEDATA
  • Business Overview
  • GENTRONIX LTD.
  • Business Overview
  • HUREL CORP.
  • Business Overview
  • IMQUEST BIOSCIENCES, INC.
  • Business Overview
  • IMSTAR SA
  • Business Overview
  • INSPHERO AG
  • Business Overview
  • KIYATEC, INC.
  • Business Overview
  • LONZA GROUP LTD.
  • Business Overview
  • Products Offered
  • METABOLON, INC.
  • Business Overview
  • MOLECULAR DEVICES LLC
  • Business Overview
  • PERKINELMER, INC.
  • Business Overview
  • PROMEGA CORP.
  • Business Overview
  • Products Offered
  • QIAGEN NV
  • Business Overview
  • Products Offered
  • SGS-SA
  • Business Overview
  • STEMINA BIOMARKER DISCOVERY, INC.
  • Business Overview
  • SYNVIVO, INC.
  • Business Overview
  • THERMO FISHER SCIENTIFIC, INC.
  • Business Overview
  • VALA SCIENCES, INC.
  • Business Overview
  • VISTAGEN THERAPEUTICS, INC.
  • Business Overview
  • XENOMETRIX AG
  • Business Overview

List of Tables
Summary Table: Global Market for In Vitro Toxicity Testing, by Region, Through 2023
Table 1: Research Institutes/Organizations that Offer In Vitro Testing and Other Services
Table 2: Instruments Used in In Vitro Toxicology Testing, 2017
Table 3: Global Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint and Test, Through 2023
Table 4: ADME In Vitro Toxicity Products
Table 5: Global Market for ADME Testing Technologies, by Region, Through 2023
Table 6: Global Market for Skin Irritation, Corrosion and Sensitization Testing Technologies, by Region, Through 2023
Table 7: Genotoxicity Testing Products
Table 8: Global Market for Genotoxicity Testing Technologies, by Region, Through 2023
Table 9: Global Market for Cytotoxicity Testing Technologies, by Region, Through 2023
Table 10: Global Market for Ocular Toxicity Testing Technologies, by Region, Through 2023
Table 11: Global Market for Organ Toxicity Testing Technologies, by Region, Through 2023
Table 12: Validated Non-animal Methods
Table 13: Global Market for Phototoxicity Testing Technologies, by Region, Through 2023
Table 14: Global Market for Dermal Toxicity Testing Technologies, by Region, Through 2023
Table 15: OECD TGs for In Vitro Genotoxicity and Mutagenicity Testing
Table 16: Global Market for Carcinogenicity Testing Technologies, by Region, Through 2023
Table 17: General Endpoints Used for In Vitro Neurotoxicity Testing
Table 18: Global Market for Neurotoxicity Testing Technologies, by Region, Through 2023
Table 19: Global Market for DART Testing Technologies, by Region, Through 2023
Table 20: Global Market for Other Toxicity Endpoints and Tests Technologies, by Region, Through 2023
Table 21: Global Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 22: Global Market for Pharmaceutical and Biotechnology End-User Industry, by Region, Through 2023
Table 23: Global Market for Healthcare End-User Industry, by Region, Through 2023
Table 24: Global Market for Food and Beverage End-User Industry, by Region, Through 2023
Table 25: Global Market for Chemical End-User Industry, by Region, Through 2023
Table 26: Chemical Companies that Provide Vitro Toxicology Services
Table 27: Global Market for Personal Care Products End-User Industry, by Region, Through 2023
Table 28: CROs Providing In Vitro Toxicology Services
Table 29: Global Market for CROs End-User Industries, by Region, Through 2023
Table 30: Global Market for Research Institutes End-User Industries, by Region, Through 2023
Table 31: Research Institutes Providing In Vitro Toxicology Tests
Table 32: Global Market for In Vitro Toxicology Testing Technologies, by Tool/Technology, Through 2023
Table 33: Global Market for Transcriptomics, by Region, Through 2023
Table 34: Global Market for Proteomics, by Region, Through 2023
Table 35: Global Market for Metabolomics, by Region, Through 2023
Table 36: Common Analytical Platforms Used in Metabolomics
Table 37: Global Market for Cellomics, by Region, Through 2023
Table 38: Global Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 39: Global Market for Assays, by Region, Through 2023
Table 40: Global Market for Equipment, by Region, Through 2023
Table 41: Global Market for Reagents and Kits, by Region, Through 2023
Table 42: Specifications of HCS LIVE/DEAD Green Kit
Table 43: Global Market for Software and Analytics, by Region, Through 2023
Table 44: Global Market for Services, by Region, Through 2023
Table 45: North American Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 46: North American Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 47: North American Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 48: North American Market for In Vitro Toxicity Testing Technologies, by Tools/Technology, Through 2023
Table 49: North American Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 50: In Vitro Services Offered by Nucro-Technics
Table 51: Tracking System for Alternative Test Methods, Review (TSAR), 2018
Table 52: European Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 53: European Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 54: European Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 55: European Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 56: European Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 57: Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 58: Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 59: Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 60: Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 61: Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 62: Top 20 R&D Pharmaceutical Companies in China
Table 63: Rest of the World Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 64: Rest of the World Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 65: Rest of the World Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 66: Rest of the World Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 67: Number of Patents, by Category in Different Countries, January 2016 to July 2018
Table 68: Patents, by Key Players, January 2016 to July 2018
Table 69: List of Patents Analyzed, January 2016 to July 2018

List of Figures
Summary Figure: Global Market for In Vitro Toxicity Testing, by Region, 2017-2023
Figure 1: Timeline of Animal Testing Ban in India
Figure 2: Regulations timeline for Cosmetic Testing on Animals
Figure 3: Comparison Between In Vivo and In Vitro Toxicity
Figure 4: Discovery Toxicology
Figure 5: Merck KGaA Toxicology Services
Figure 6: Global Per Capita Healthcare Expenditure, by Country, 2016
Figure 7: In Vitro Toolbox for Acute Inhalation Toxicity
Figure 8: Features of ToxiScreen
Figure 9: Drug Discovery Process
Figure 10: Use of Metabolomics Toxicology
Figure 11: Types of Toxicity Studies
Figure 12: Features of Thiol Tracker Violet
Figure 13: Features of TraceFinder Software
Figure 14: Healthcare Expenditures for R&D, by State and Performer, FY 2016
Figure 15: Total Health Expenditures, by Source of Finance, 2016
Figure 16: Healthcare Expenditure as a Share of GDP, by Region/Country, 2015
Figure 17: E.U. Innovation Funding, by Horizon 2020, by Projects, 2014-2022
Figure 18: Biotech Funding in the U.K., 2017
Figure 19: Active Market Players in the U.K.
Figure 20: Germany Health Spending, 2013-2016
Figure 21: Research and Development Funding in Health Research and Health Industry, 2016-2017
Figure 22: Chinese Pharmaceutical Sales, 2015 and 2020
Figure 23: List of Programs and Description
Figure 24: Japan’s Pharmaceutical R&D Expenditure, 1995-2015
Figure 25: Indian’s Pharmaceutical Exports, 2014-2018
Figure 26: Thermo Fisher Scientific, Inc.: Revenue Share, by Segment, 2017
Figure 27: Thermo Fisher Scientific, Inc.: Share of Revenue Generation, by Region, 2017

Note: Product cover images may vary from those shown
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4 of 5

FEATURED COMPANIES

  • Abbott Laboratories, Inc.
  • Biovia
  • Drik Llc
  • Genedata
  • Insphero Ag
  • Perkinelmer, Inc.
  • MORE

The cost of animal testing is high, with some substances costing more than several million dollars. Along with the high cost of toxicity testing, animal welfare is another key concern that calls for alternative testing methods. In vitro model systems, like cell-based models, can significantly reduce costs and the use of animals in toxicity testing. The increasing need for non-animal tests in toxicity testing is driving demand in the in vitro toxicity market. In vitro models are used to gain a better understanding of chemical-induced toxicity in animals and humans. The in vitro test model primarily serves as a rapid screening system for the toxicologic evaluation of chemicals. These models may complement in vivo toxicity tests or may replace some in vivo models if scientifically validated and accepted by regulatory agencies.

The most common in vitro models are isolated tissue preparations, perfused organ preparations, single-cell suspensions, and cell-culture systems (like primary cell cultures) and mammalian cell lines. Cell culture systems often are used because they are reliable, reproducible, and relatively inexpensive testing methods that assess chemical toxicity at the cellular level. Further, non-animal toxicity test methods have been used for determining cellular toxicity by manufacturers to support decisions for conducting conventional animal testing.

The growing demand for in vitro toxicity testing during the drug discovery process and increasing number of contract research organizations (CRO) are major drivers of the global in vitro toxicity market. The Developmental Therapeutics Program at the National Cancer Institute (DTP 2005) developed an in vitro cell-line screen to support its drug-discovery program. For potential anticancer activity, the in vitro cell-line screen test can screen up to 20,000 compounds per year. The in vitro cell-line screen test uses 60 human tumor cell lines, representing various cancers such as skin cancer, breast cancer, colon cancer, brain cancer, prostate cancer, blood cancer, and kidney cancer.

Charles River, GVK Biosciences Private Ltd., Sekisui XenoTech LLC and Merck KGaA are among a large number of CROs that offer in vitro toxicity services. The increasing demand for animal-free toxicity tests driving the growth of the global in vitro toxicity market. In vitro toxicity tests are reliable, cost-effective and do not use animals, unlike in vivo tests. The rising global prevalence of chronic diseases has significantly increased demand for the discovery of novel drugs. The toxicity study of drugs and compounds is performed by the regulatory bodies, in order to facilitate the approval of drugs and devices.

The high cost of toxicology equipment, inadequate infrastructure and funding for R&D in emerging countries are expected to hinder the growth of the global in vitro toxicity market. High-throughput screening (HTS) equipment is expensive, particularly for small and emerging countries that wish to purchase multiple instruments. Their high cost may hinder market growth in these countries. However, governments, companies and research institutes are extensively funding for toxicology research, which should overcome the cost challenges and drive market growth during the forecast period. Also, regulatory programs such as TOX21, ToxCast program and NTP (National Toxicology Program) are creating
enormous opportunities for companies in the in vitro toxicity global market.

Note: Product cover images may vary from those shown
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  • Abbott Laboratories, Inc.
  • Acea Biosciences, Inc.
  • Agilent Technologies, Inc.
  • Albany Molecular Research, Inc.
  • Aptuit, Inc.
  • Biognosys Ag
  • Bioreliance
  • Biovia
  • Business Overview
  • Cellular Dynamics International, Inc.
  • Chantest
  • Charles River Laboratories
  • Covance, Inc.
  • Cyprotex Plc
  • Drik Llc
  • Enzo Life Sciences, Inc.
  • Essen Bioscience, Inc.
  • Eurofins Scientific Se
  • Evotec Ag
  • GE Healthcare Life Sciences
  • Genedata
  • Gentronix Ltd.
  • Hurel Corp.
  • Imquest Biosciences, Inc.
  • Imstar Sa
  • Insphero Ag
  • Kiyatec, Inc.
  • Lonza Group Ltd.
  • Metabolon, Inc.
  • Molecular Devices Llc
  • Perkinelmer, Inc.
  • Promega Corp.
  • Qiagen Nv
  • SGS-SA
  • Stemina Biomarker Discovery, Inc.
  • Synvivo, Inc.
  • Thermo Fisher Scientific, Inc.
  • Vala Sciences, Inc.
  • Vistagen Therapeutics, Inc.
  • Xenometrix Ag
Note: Product cover images may vary from those shown
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