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High-Throughput Screening: Technologies and Global Markets

  • ID: 4745516
  • Report
  • January 2019
  • Region: Global
  • 214 Pages
  • BCC Research
1 of 5

FEATURED COMPANIES

  • Agilent Technologies Inc.
  • Biotek Instruments Inc.
  • Danaher Corp.
  • GE Healthcare
  • Milliporesigma
  • PerkinElmer Inc.
  • MORE

Report Scope:

The HTS market has significant potential due to the rising demand for drug discovery, DNA sequencing, toxicity studies, and genomics applications. The capabilities and possibilities of market growth increase with new technologies and technological advancement. Emerging economies such as China, India, Latin American and Eastern Europe are considered lucrative regions that are creating opportunities and scope for the HTS market. Significant investments and funding are coming from government and private ventures, research institutes and universities to explore the potential of this market.

The scope of this study includes the current market for drug discovery, protein analysis, biologically active compound screening, and compound profiling. The report also includes regulations, recent developments, market projections, the competitive landscape, and market share. An analysis of patents, clinical trials, innovations, opportunities, and the latest trends are also discussed in the report. The report explains the key trends of HTS technologies and applications in regions around the world. It also discusses the market determinants that act as motivating and restraining factors and provides insights to stakeholders and potential entrants. The report will be a key decision-making tool for government organizations, researchers, private players, angel investors, potential entrants and so forth.

The Report Includes:

  • 60 data tables and 30 additional tables
  • An industry analysis of technologies and global markets for the high-throughput screening (HTS) within the industry
  • Analyses of global market trends with data from 2017 to 2018, and projections of compound annual growth rates (CAGRs) through 2023
  • Characterization and quantification of the market potential for HTS by geographical regions, technology types, detection methods, components, application segments, and end-use industries
  • A look at the influence of government regulations, technological updates and the economic factors augmenting the growth of the market
  • Relevant patent analysis within the global HTS market
  • Company profiles of the major market players and their corporate profiles, including Agilent Technologies Inc., Bio-Rad Laboratories Inc., Danaher Corp., GE Healthcare, Nikon Instruments Inc., PerkinElmer Inc., Sysmex Corp., and Thermo Fisher Scientific Inc.
Note: Product cover images may vary from those shown
2 of 5

FEATURED COMPANIES

  • Agilent Technologies Inc.
  • Biotek Instruments Inc.
  • Danaher Corp.
  • GE Healthcare
  • Milliporesigma
  • PerkinElmer Inc.
  • MORE

Chapter 1 Introduction

  • Study Goals and Objectives
  • Intended Audience
  • Scope of Report
  • Information Sources
  • Methodology
  • Geographic Breakdown
  • Analyst's Credentials
  • Custom Research
  • Related Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

  • Market Trends
  • North America Dominates the Market
  • Significant Growth in APAC
  • Major Opportunities for Software and Bioinformatics
  • Evolution of High-Throughput Screening
  • Miniaturization of Assays for High-Throughput Screening
  • Optimization of High-Throughput Screening
  • Traditional and Novel Targets for Lead Discovery
  • HTS Milestones Since Inception
  • Conclusion
  • Overview of Microscope and Imaging Technologies
  • Scanning Probe Microscopy
  • Scanning Electron Microscopy
  • Transmission Electron Microscopy
  • Artificial Intelligence and Automated Devices in HTS
  • Technological Advancements
  • Cytometers
  • Detectors and Sensors
  • Liquid Handling Instruments
  • Technological Trends
  • Label-Free Technology
  • Microplate Technologies
  • Automation and Miniaturization
  • Microfluidics
  • Market Dynamics
  • Market Drivers
  • Market Opportunities
  • Limitations and Challenges

Chapter 4 Market Breakdown by Detection Method

  • Spectroscopy
  • Fluorescence Spectroscopy
  • Total Internal Reflection Fluorescence (TIRF)
  • Nuclear Magnetic Resonance (NMR)
  • Fourier Transformed Infrared (FTIR)
  • Light Scattering
  • Mass Spectrometry (MS)
  • Imaging Mass Spectrometry
  • MALDI Mass Spectrometry
  • Secondary Ion Mass Spectrometer
  • Mass Spectrometry Instruments
  • Chromatography
  • Gas Chromatography
  • Thin-Layer Chromatography
  • Liquid Chromatography
  • Ion Exchange Chromatography
  • Affinity Chromatography
  • Reversed-Phase Chromatography
  • Hydrophobic Interaction Chromatography
  • Calorimetry
  • Isothermal Titration Calorimetry
  • Differential Scanning Calorimetry
  • X-ray Diffraction
  • Microscopy

Chapter 5 Market Breakdown by Component

  • Instruments/Platforms
  • Imaging Devices
  • Microplate Readers
  • Cytometers
  • Liquid Handling Instruments
  • Consumables: Reagents and Kits
  • Software and Analytics (Bioinformatics)
  • ProMass Deconvolution Software by Thermo Fisher Scientific
  • Services
  • ADME Screening
  • SiRNA Screening

Chapter 6 Market Breakdown by Technology

  • Cell-Based Assays
  • Lab-on-a-Chip
  • Ultra-High-Throughput Screening
  • Label-Free Technology

Chapter 7 Market Breakdown by End User

  • Pharmaceutical and Biotechnology Companies
  • Research and Government Institutes
  • Lab and Pathology Facilities
  • Contract Research Organizations

Chapter 8 Market Breakdown by Application

  • Drug Discovery
  • Biological Active Compound Screening
  • Genomics Application
  • DNA Sequencing
  • Protein Analysis
  • Microarray Screening
  • Toxicity Studies
  • Compound Profiling

Chapter 9 Market Breakdown by Region

  • North America
  • United States
  • Canada
  • Europe
  • United Kingdom
  • Germany
  • France
  • Spain
  • Italy
  • Rest of Europe
  • Asia-Pacific
  • India
  • Japan
  • China
  • Rest of APAC
  • Rest of the World
  • Middle East
  • Africa
  • Latin America

Chapter 10 Patent Analysis and New Developments

  • New Technologies
  • DNA-Encoded Libraries
  • High-Throughput Screening with CRISPR-Cas9 and RNAi
  • High-Throughput Screening Using Artificial Intelligence and Machine Learning
  • High-Throughput Screening in Academia for Biomedical Research
  • Advances in Zebrafish High-Throughput Screening Technologies
  • Evolution of Ultra-High-Throughput Screening
  • Patent Analysis
  • New Developments
  • New Product Development

Chapter 11 Analysis of Market Opportunities

  • Key Supplier and Manufacturer Positioning and Strategy
  • Key Market Players in the High-Throughput Screening Market
  • Albany Molecular Research Inc.
  • PerkinElmer Inc.
  • Bio-Rad Laboratories Inc.
  • Thermo Fisher Scientific Inc.
  • Analysis of Primary Strategies
  • Research and Development Activities

Chapter 12 Company Profiles

  • Agilent Technologies Inc.
  • Albany Molecular Research Inc.
  • Aurelia Bioscience Ltd.
  • Axxam Spa
  • Becton, Dickinson And Co.
  • Bio-Rad Laboratories Inc.
  • Biotek Instruments Inc.
  • Carl Zeiss Ag
  • Cell Signaling Technology Inc.
  • Charles River Laboratories Inc.
  • Corning Inc.
  • Creative Biolabs Inc.
  • Curiox Biosystems Pte Ltd.
  • Cytoo Sa
  • Danaher Corp.
  • DE Novo Software
  • Eurofins Discoverx Corp.
  • Evotec Ag
  • Fluxion Biosciences Inc.
  • GE Healthcare
  • Genedata Ag
  • Hudson Robotics Inc.
  • Instrument Systems Gmbh
  • Intellicyt Corp.
  • Milliporesigma
  • Molecular Devices Llc
  • Nemametrix Inc.
  • Nikon Instruments Inc.
  • Olympus Corp.
  • Perkinelmer Inc.
  • Phenovista Biosciences Llc
  • Platypus Technologies
  • Sysmex Corp.
  • Tecan Group Ltd.
  • Thermo Fisher Scientific Inc.
  • TTP Labtech Ltd.
  • Vala Sciences Inc.

List of Tables
Summary Table: Global Market for High-Throughput Screening, by Region, Through 2023
Table 1: Microscope Manufacturers Using HTS, 2018
Table 2: Automated Microplate Handling Systems in High-Throughput Screening
Table 3: R&D Spending of Major Pharmaceutical Companies, 2013
Table 4: R&D Spending in Pharmaceuticals, by Select OECD Countries, 2011-2012
Table 5: Uses of High-throughput Platforms for Investigating Stem Cell Microenvironments
Table 6: Comparison of High-Throughput Screening Microscopes, 2018
Table 7: Global Market for High-Throughput Screening, by Detection Method, Through 2023
Table 8: Global Market for Spectroscopy, by Region, Through 2023
Table 9: Microplate Reader Products of BMG Labtech, with Detection Method
Table 10: Global Market for Mass Spectrometry, by Region, Through 2023
Table 11: Global Market for Chromatography, by Region, Through 2023
Table 12: Chromatographers Available in the Market
Table 13: Typical Applications for Predictor 96-Well Plates
Table 14: Gas Chromatography Instruments, by Shimadzu Corp. for High-Throughput Screening
Table 15: High-Performance Liquid Chromatography Systems
Table 16: Global Market for Calorimetry, by Region, Through 2023
Table 17: DCS Products Example
Table 18: Global Market for X-Ray Diffraction, by Region, Through 2023
Table 19: Select Available Products
Table 20: Global Market for Microscopy, by Region, Through 2023
Table 21: Global Market for High-Throughput Screening, by Component, Through 2023
Table 22: Global Market for Instruments/Platform, by Segment, Through 2023
Table 23: Global Market for Instruments and Platforms, by Region, Through 2023
Table 24: High-Throughput Screening Instruments
Table 25: Cytometers on the Market
Table 26: Automated Liquid Handling Modules on the Market
Table 27: Global Market for Consumables, by Region, Through 2023
Table 28: Global Market for Software and Analytics, Through 2023
Table 29: Global Market for High-Throughput Screening, by Region, Through 2023
Table 30: Global Market for High-Throughput Screening, by Technology, Through 2023
Table 31: Global Market for Cell-Based Assays, by Region, Through 2023
Table 32: Types of Cell-Based Assays Used in High-Throughput Screening for Drug Discovery
Table 33: Examples of Cell-Based Assays for High-Throughput Screening
Table 34: Global Market for Lab-on-a-Chip, by Region, Through 2023
Table 35: Global Market for Ultra-High-Throughput Screening, by Region, Through 2023
Table 36: Global Market for Label-Free Technology, by Region, Through 2023
Table 37: Label-Free Technology for High-Throughput Screening
Table 38: Global Market for High-Throughput Screening, by End User, Through 2023
Table 39: Global Market for Pharmaceutical and Biotechnology Company End Users of High-Throughput Screening, by Region, Through 2023
Table 40: Global Market for Research and Government Institute End Users of High-Throughput Screening, by Region, Through 2023
Table 41: Research Institutes with High-Throughput Screening Facilities
Table 42: Global Market for Lab and Pathology Facility End Users of High-Throughput Screening, by Region, Through 2023
Table 43: Global Market for Contract Research Organization End Users of High-Throughput Screening, by Region, Through 2023
Table 44: Global Market for High-Throughput Screening, by Application, Through 2023
Table 45: Global Market for Drug Discovery Applications of High-Throughput Screening, by Region, Through 2023
Table 46: Global Market for Biological Active Compound Screening Applications of High- Throughput Screening, by Region, Through 2023
Table 47: Global Market for Genomics Applications of High-Throughput Screening, by Region, Through 2023
Table 48: Global Market for DNA Sequencing Applications of High-Throughput Screening, by Region, Through 2023
Table 49: Global Market for Protein Analysis Applications of High-Throughput Screening, by Region, Through 2023
Table 50: Global Market for Microarray Applications of High-Throughput Screening, by Region, Through 2023
Table 51: Global Market for the Application of High-Throughput Screening in Toxicity Studies, by Region, Through 2023
Table 52: Global Market for Compound Profiling Applications of High-Throughput Screening, by Region, Through 2023
Table 53: Global Market for High-Throughput Screening, by Region, Through 2023
Table 54: North American Market for High-Throughput Screening, by Country, Through 2023
Table 55: North American Market for High-Throughput Screening, by Technology, Through 2023
Table 56: North American Market for High-Throughput Screening, by Component, Through 2023
Table 57: North American Market for High-Throughput Screening, by End User, Through 2023
Table 58: North American Market for High-Throughput Screening, by Application, Through 2023
Table 59: North American Market for High-Throughput Screening, by Detection Method, Through 2023
Table 60: Total Pharmaceutical Business R&D Expenditures, 2011-2015
Table 61: European Market for High-Throughput Screening, by Country, Through 2023
Table 62: European Market for High-Throughput Screening, by Technology, Through 2023
Table 63: European Market for High-Throughput Screening, by Component, Through 2023
Table 64: European Market for High-Throughput Screening, by End User, Through 2023
Table 65: European Market for High-Throughput Screening, by Application, Through 2023
Table 66: European Market for High-Throughput Screening, by Detection Method, Through 2023
Table 67: Asia-Pacific Market for High-Throughput Screening, by Country, Through 2023
Table 68: Asia-Pacific Market for High-Throughput Screening, by Technology, Through 2023
Table 69: Asia-Pacific Market for High-Throughput Screening, by Component, Through 2023
Table 70: Asia-Pacific Market for High-Throughput Screening, by End User, Through 2023
Table 71: Asia-Pacific Market for High-Throughput Screening, by Application, Through 2023
Table 72: Asia-Pacific Market for High-Throughput Screening, by Detection Method, Through 2023
Table 73: Vaccine Manufacturers in India
Table 74: Clinical Research Institutes in India
Table 75: R&D Presence in China of Top 20 Pharmaceutical Companies
Table 76: Academic Screening Facilities in China
Table 77: RoW Market for High-Throughput Screening, by Technology, Through 2023
Table 78: RoW Market for High-Throughput Screening, by End User, Through 2023
Table 79: RoW Market for High-Throughput Screening, by Component, Through 2023
Table 80: RoW Market for High-Throughput Screening, by Detection Method, Through 2023
Table 81: RoW Market for High-Throughput Screening, by Application, Through 2023
Table 82: Total Number of Patents in High-Throughput Screening, 2016-2018
Table 83: Number of Patents on High-Throughput Screening, by Key Players, 2016-2017
Table 84: U.S. Patents on High-Throughput Screening, January 2016 to July 2018
Table 85: European Patents on High-Throughput Screening, January 2016 to July 2018
Table 86: Japanese Patents on High-Throughput Screening, January 2016 to July 2018
Table 87: Company Product Portfolios of High-Throughput Screening Systems
Table 88: Albany Molecular Research Subsidiaries and Their Business Activities, 2015-2016
Table 89: Innovations and Advancements in Existing Products of Thermo Fisher Scientific, 2018

List of Figures
Summary Figure: Global Market for High-Throughput Screening, by Region, 2017-2023
Figure 1: High-Throughput Screening Well Specification
Figure 2: Triangle of High-Throughput Screening
Figure 3: First-Generation High-Throughput Screening, 1993-2000: Throughput
Figure 4: Second-Generation High-Throughput Screening, 2001-2006: Efficiency
Figure 5: Third-Generation High-Throughput Screening, 2007 Onward: Flexibility
Figure 6: Alternative Approaches to Image Sample Surface
Figure 7: Top 10 CRO Companies, by Revenue, 2017
Figure 8: Global Pharmaceutical R&D Spending, 2009-2015
Figure 9: Global Funding for Diseases, 2014-2016
Figure 10: GDP Growth Rate of India and China, 2013-2016
Figure 11: Components of Mass Spectrometer
Figure 12: Advantages of MALDI-TOF instruments
Figure 13: Advantages of Thin-Layer Chromatography
Figure 14: Features of 1290 Infinity II High-Throughput System
Figure 15: Advantages and Disadvantages of Ion Exchange Chromatography
Figure 16: Research Challenges for High-Throughput Light Microscope Analysis of Cells and Tissue
Figure 17: Features of ProMass Deconvolution Software
Figure 18: Features of Trace Finder Software
Figure 19: Process of uHTS System
Figure 20: Key Pharmaceutical and Biotechnology Companies Providing High-Throughput Screening
Figure 21: Drug Discovery Process Using High-Throughput Screening
Figure 22: Benefits of High-Throughput Screening in Biological Active Compound Screening
Figure 23: Types of Toxicity Studies
Figure 24: Strategies to Improve Screening Using Compound Profiling
Figure 25: Gross Domestic Spending on Healthcare R&D in North American Countries, 2016
Figure 26: U.S. Healthcare Expenditures on R&D, by State, FY 2016
Figure 27: Surveillance of Viral Hepatitis in the U.S., 2015
Figure 28: Total Health Expenditure Shares in Canada, by Source of Funds, 2016
Figure 29: Distribution of Causes of Mortality in Canada, 2017
Figure 30: Horizon 2020 Funding, by Sector, 2014-2022
Figure 31: European Healthcare Expenditures as a Share of GDP, by Sector, 2015
Figure 32: European Healthcare Expenditures, as a Share of GDP, 2015
Figure 33: Biotech Funding in the U.K., by Type of Source, 2017
Figure 34: Investors in New and Existing Capital Expenditures, 2016
Figure 35: Germany’s Total Healthcare Spending, 2013-2016
Figure 36: R&D Funding in Healthcare Research and the Healthcare Industry, 2016 and 2017
Figure 37: Systems Used in High-Throughput Screening Platform at I-Stem
Figure 38: Mortality from Cancer in Italy, 2011-2017
Figure 39: European Countries with High Cancer Mortality, 2014
Figure 40: Indian Healthcare Expenditures, 2004-2014
Figure 41: Pharmaceutical R&D Expenditures in Japan, 1995-2015
Figure 42: China’s Healthcare Expenditures, by Sector, 2016
Figure 43: Factors That Allow AMRI To Stay Competitive in The Market
Figure 44: PerkinElmer Strategies
Figure 45: Strategies Adopted by Key Market Players

Note: Product cover images may vary from those shown
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4 of 5

FEATURED COMPANIES

  • Agilent Technologies Inc.
  • Biotek Instruments Inc.
  • Danaher Corp.
  • GE Healthcare
  • Milliporesigma
  • PerkinElmer Inc.
  • MORE

HTS was invented in 1951 by Dr. Gyula Takatsky; six rows of 12 wells in Lucite were machined to develop the first microtiter plate. Technology and approaches for HTS have advanced in the last few years. High-throughput screening is a modern technique used in drug development that can be applied in the biological and chemical sciences. The application of robots, detectors, sensors and software enables a variety of analyses of chemical and biological compounds. This analysis can be conducted in a short time, and the toxicity of biological structures and characteristics of metabolic and pharmacokinetic processes can be determined.

HTS aims to lead discovery for both pharmaceutical and agrochemical applications. The primary goal for pharmaceutical companies is to restructure drug discovery programs to develop the highest -performing drugs. Companies are prioritizing innovation in HTS as a major strategy in an increasingly competitive environment. The latest developments in molecular biology, chemistry, pharmacology, laboratory automation, bioinformatics and computing enable the discovery of new and innovative drugs. Furthermore, HTS enables the determination of cytotoxicity, which leads to significant decreases in expenditures and reductions in the length of the study.

HTS has become a key tool for companies and research industries, due to its ability to test large numbers of compounds quickly and efficiently. There are also opportunities for companies that can identify and implement new technology effectively. Effective integration of compound supply, assay operation, and data management are essential to achieving necessary productivity. HTS is an advanced technology initiative that can utilize the advantages of the latest advances in bioscience, biotechnology, engineering, and information science. A rising number of drug targets for screening, the large numbers of reagents and assay kits used in HTS techniques and increasing pharmaceutical R&D are boosting the
market. Additionally, considerable investments by government and research institutes in drug discovery are other factors that will drive the HTS market in the future.

High-throughput screening enables researchers to screen huge chemical libraries against a growing number of targets for lead discovery. Drug discovery is significantly relying on both HTS and uHTS screening capability, as well as the automation technology. Ultra-high-throughput screening is defined as screening more than 100,000 generated data points per day.

Laboratory automation has grown from a novel technology to being widely used in combination with HTS technology. Applications of laboratory automation include sample generation and preparation, genomics and proteomics for target finding and validation, robotic storage devices, automated multiple parallel synthesis stations, parallel liquid handling systems, workstations and fully integrated robots for primary biological screening. Technological advancement in automation will expand the number of hits and be beneficial in hit discovery, hit profiling, pharmacological testing, re-synthesis in gram quantities and in vivo profiling. Further, artificial intelligence has the ability to analyze large amounts of data generated during biological research. Artificial intelligence enables drug discovery for rare and neglected disease by utilizing HTS datasets and machine learning models in order to identify molecules for further testing. The machine learning models have already been used for identifying lead molecules for tuberculosis therapies.

Note: Product cover images may vary from those shown
5 of 5
  • Agilent Technologies Inc.
  • Albany Molecular Research Inc.
  • Aurelia Bioscience Ltd.
  • Axxam Spa
  • Becton, Dickinson And Co.
  • Bio-Rad Laboratories Inc.
  • Biotek Instruments Inc.
  • Carl Zeiss Ag
  • Cell Signaling Technology Inc.
  • Charles River Laboratories Inc.
  • Corning Inc.
  • Creative Biolabs Inc.
  • Curiox Biosystems Pte Ltd.
  • Cytoo Sa
  • Danaher Corp.
  • DE Novo Software
  • Eurofins Discoverx Corp.
  • Evotec Ag
  • Fluxion Biosciences Inc.
  • GE Healthcare
  • Genedata Ag
  • Hudson Robotics Inc.
  • Instrument Systems Gmbh
  • Intellicyt Corp.
  • Milliporesigma
  • Molecular Devices Llc
  • Nemametrix Inc.
  • Nikon Instruments Inc.
  • Olympus Corp.
  • PerkinElmer Inc.
  • Phenovista Biosciences Llc
  • Platypus Technologies
  • Sysmex Corp.
  • Tecan Group Ltd.
  • Thermo Fisher Scientific Inc.
  • Thermo Fisher Scientific Inc.
  • TTP Labtech Ltd.
  • Vala Sciences Inc.
Note: Product cover images may vary from those shown
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