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Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics

  • ID: 4745967
  • Book
  • June 2019
  • Region: Global
  • 432 Pages
  • Elsevier Science and Technology
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Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers.

Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems.

  • Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy
  • Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer
  • Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

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1. Current status and future challenges of various polymers as cancer therapeutics 2. An overview of polymeric nanoparticles as potential cancer therapeutics 3. Poly acrylate (e.g., poly methylacrylate, poly ethyl acrylate, etc.) nanoparticles as promising tool for anticancer therapeutics 4. Poly (alkyl cyano acrylate) nanoparticles as promising tool for anticancer therapeutics 5. Poly (?-hydroxy acids) based nanoparticles for Drug/Gene delivery for cancer therapy 6. Poly (ester), Poly hydroxy alkanoate nanoparticles as promising tool for anticancer therapeutics 7. Poly (phospho ester), Poly (phosphazene) nanoparticles as promising tool for anticancer therapeutics 8. Poly (carbonate) nanoparticles as promising tool for anticancer therapeutics 9. Poly (amino acid) nanoparticles as promising tool for anticancer therapeutics 10. Poly ethylene glycol nanoparticles as promising tool for anticancer therapeutics 11. Dendrimer (polyamidoamine, polypropylene imine, poly-L-lysine, carbosilane dendrimers, triazine dendrimers) as promising tool for anticancer therapeutics 12. Conjugated polymer nanoparticles as promising tool for anticancer therapeutics 13. Microbes based natural polymer (Xanthum gum, alginate, gellan gum, carrageenan) nanoparticles as promising tool for anticancer therapeutics 14. Plant based natural polymer (Guar gum, pectin, starch, cellulose, cyclodextrins) nanoparticles as promising tool for anticancer therapeutics 15. Animal based natural polymer (Gelatin, chitosan, albumin, hyaluronic acid, chondroitin sulphate) nanoparticles as promising tool for anticancer therapeutics 16. Polymersomes as promising tool for anticancer therapeutics 17. Other polymers (Poly sulfonic acids, Poly carboxylic acids, Poly boronic acid, Poly silamine, etc.) nanoparticles as promising tool for anticancer therapeutics 18. Conclusion and future prospective of polymeric nanoparticles as cancer therapeutics

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Kesharwani, Prashant
Dr. Prashant Kesharwani is currently working as Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He received his doctoral degree in Pharmaceutical Sciences from the Dr H.S. Gour University (Sagar, India) with Prof N.K Jain's group. He is a recipient of several internationally acclaimed awards viz "Ramanujan Fellowship, DST, India-2017”, "Excellence Research Award-2014”, "Young Innovator Award (Gold medal)-2012”, "International Travel Award/Grant from DST (New Delhi), and INSA (CCSTDS, Chennai)-2012”. He has received ICMR Senior Research Fellowship (in PhD) and AICTE Junior Research Fellowship (in M. Pharm.). After his doctorate, he worked as postdoctoral fellows in the Wayne State University, Detroit (Michigan, USA). Dr. Kesharwani subsequently joined the School of Pharmacy, International Medical University (Malaysia) as lecturer in Pharmaceutical Technology. Subsequently he joined Central Drug Research Institute (CDRI), Lucknow as Ramanujan Fellow. An overarching goal of his current research is the development of nano-engineered drug delivery systems for cancer through with prime focus on dendrimer and polymeric nanomicelles mediated drug delivery systems. Dr. Kesharwani is a co-author on more than 120 publications in high impact factor international journals and 4 international books with total citations of more than 3300 (h index is 27 and i-10 index is 65 as per Google Scholar).
Paknikar, Kishore M.
Dr. Kishore M. Paknikar is Professor Agharkar Chair and former Director of Agharkar Research Institute, Pune, India. He is a MSc in Microbiology (1980) and a PhD in Microbiology (1984) from the University of Poona, India. His work in the field of delivery systems focuses on the delivery of drugs, proteins, peptides, siRNA, and nutrients. He is also exploring systems like polymeric nanoparticles and dendrimers for delivery of bioactive molecules in the treatment of cancers, Alzheimer's disease, candidiasis, etc. He has more than 120 publications in highly reputed journals and 33 patents to his credit. He was a visiting Professor at Louis Pasteur University (Strasbourg, France) and Wayne State University (School of Medicine, Detroit, USA). He also worked as a Research Advisor at National Nanotechnology Centre (Ministry of Science and Technology), Bangkok, Thailand. He has several fellowships and awards to his credit.
Gajbhiye, Virendra
Dr. Virendra Gajbhiye has been working in the field of nanomedicine for the last 12 years. He has a PhD in pharmaceutical science with post-doctoral research experience at the University of Wisconsin-Maddison and Oregon State University. Since 2013 he has been working as a Scientist in Nanomedicine at Agharkar Research Institute, Pune, India. He has worked extensively with polymeric nanoparticles specially dendrimers. His research interests lies in nanomedicine, targeted drug and siRNA delivery, biomedical application of dendrimers, biomaterials unimolecular micelles and imaging, multifunctional polymeric nanoparticles, and nanoparticles in tissue engineering.
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